Cowell1: Host response to Staphylococcus aureus infection in females of 13 inbred strains of mice (2012)

Johnson NV, Ahn SH, Deshmukh H, Levin MK, Nelson CL, Scott WK, Allen A, Fowler VG Jr, Cowell LG. Haplotype Association Mapping Identifies a Candidate Gene Region in Mice Infected With Staphylococcus aureus. G3 (Bethesda). 2012 Jun;2(6):693-700. Epub 2012 Jun 1.   PubMed 22690378     FullText


       
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Participants Lindsay G Cowell       University of Texas - Southwestern Dallas, TX
Vance G Fowler       Duke University Medical Center Durham, NC
With: Johnson NV, Ahn SH, Deshmukh H, Levin MK, Nelson CL, Scott WK, Allen A
ContactLindsay G Cowell     Lindsay.Cowell@UTSouthwestern.edu     Lab web site
AcknowledgementsFunding provided by NIH AI068804, AI077706; Burroughs Wellcome Fund
Project type Phenotype strain survey data set
MPD identifiersCowell1     MPD:490
Data changelog No updates/corrections.       Initial release date: 10/2013.
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Summary of procedures that were conducted
• health assessment Survival rate, Staphylococcus aureus.
• hormone quantification Interleukin 6 levels (serum) after infection with Staphylococcus aureus. Kidney and peritoneal fluid.
• in vitro assay Bacterial load after infection with Staphylococcus aureus. Kidney and peritoneal fluid. In vitro assay.
Mice: inbred   13 strains   ♀   age 8wks   3 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Cowell1 49001 hormone quantification Staphylococcus aureus fold-change in serum IL-6 levels 24h post-infection compared to controls   [ratio]  IL6 inbred 13 f 8wks N=3
    Cowell1 49002 in vitro assay Staphylococcus aureus log10 bacterial colony count from peritoneal fluid 24h post-infection (x 103) (CFU/mL)   [log(n/mL)]  peritoneal_CFU inbred 13 f 8wks N=5
    Cowell1 49003 in vitro assay Staphylococcus aureus log10 bacterial colony count from kidney 24h post-infection (CFU/g)   [log(n/g)]  kidney_CFU inbred 13 f 8wks N=6
    Cowell1 49004 health assessment Staphylococcus aureus median survival time (max time = 104 h)   [h]  median_survival inbred 13 f 8wks N=11
    Cowell1 49005 health assessment Staphylococcus aureus percent survival (max time = 104 h)   [%]  pct_survival inbred 13 f 8wks N=11
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