Collins1: Hematological parameters in 8 inbred founder strains and 130+ emerging lines (pre-CC) of the Collaborative Cross (2012)

Kelada SN, Aylor DL, Peck BC, Ryan JF, Tavarez U, Buus RJ, Miller DR, Chesler EJ, Threadgill DW, Churchill GA, Pardo-Manuel de Villena F, Collins FS. Genetic analysis of hematological parameters in incipient lines of the collaborative cross. G3 (Bethesda). 2012 Feb;2(2):157-65. Epub 2012 Feb 1.   PubMed 22384394     FullText


       
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Participants Francis S Collins       National Institutes of Health Bethesda, MD
With: Kelada SP, Aylor DL, Peck BE, Ryan JF, Tavarez U, Buus RJ, Miller DR, Chesler EJ, Threadgill DW, Churchill GA, de Villena FP
ContactFrancis S Collins     collinslab@mail.nih.gov     Lab web site
AcknowledgementsFunding provided by NIH CA134240, CA105417, GM090667, GM076468; and in part by the intramural program of the National Human Genome Research Institute and the U.S. Department of Energy
Project type Phenotype strain survey data set
MPD identifiersCollins1     MPD:451
Data changelog 1 update/correction.       Initial release date: 01/2013.
Formatted citation
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An assessment of emerging CC lines. Generations range from G2:F5 to G2:F14. Data for the 8 founder strains are also present.

Summary of procedures that were conducted
• complete blood count Hematology.
Mice: CC pre   139 strains including progenitors   ♂   age 10-14wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Collins1 45101 complete blood count (none) red blood cell count (RBC; per volume x 106)   [n/µL]  RBC CC pre w/CC8 139 m 10-14wks N=1
    Collins1 45102 complete blood count (none) white blood cell count (WBC; per volume x 103)   [n/µL]  WBC CC pre w/CC8 138 m 10-14wks N=1
    Collins1 45103 complete blood count (none) lymphocyte count (LYM; per volume x 103)   [n/µL]  LYM CC pre w/CC8 138 m 10-14wks N=1
    Collins1 45104 complete blood count (none) lymphocyte differential (LYM; percent of total WBC)   [%]  LYM_pct CC pre w/CC8 138 m 10-14wks N=1
    Collins1 45105 complete blood count (none) neutrophil count (NEUT; per volume x 103)   [n/µL]  NEUT CC pre w/CC8 138 m 10-14wks N=1
    Collins1 45106 complete blood count (none) neutrophil differential (NEUT; percent of total WBC)   [%]  NEUT_pct CC pre w/CC8 138 m 10-14wks N=1
    Collins1 45107 complete blood count (none) monocyte count (MONO; per volume x 103)   [n/µL]  MONO CC pre w/CC8 138 m 10-14wks N=1
    Collins1 45108 complete blood count (none) monocyte differential (MONO; percent of total WBC)   [%]  MONO_pct CC pre w/CC8 138 m 10-14wks N=1
    Collins1 45109 complete blood count (none) eosinophil count (EOS; per volume x 103)   [n/µL]  EOS CC pre w/CC8 138 m 10-14wks N=1
    Collins1 45110 complete blood count (none) eosinophil differential (EOS; percent of total WBC)   [%]  EOS_pct CC pre w/CC8 138 m 10-14wks N=1
    Collins1 45111 complete blood count (none) basophil count (BASO; per volume x 103)   [n/µL]  BASO CC pre w/CC8 138 m 10-14wks N=1
    Collins1 45112 complete blood count (none) basophil differential (BASO; percent of total WBC)   [%]  BASO_pct CC pre w/CC8 138 m 10-14wks N=1
    Collins1 45113 complete blood count (none) RBC corpuscular distribution width (RDW)   [%]  RDW CC pre w/CC8 139 m 10-14wks N=1
    Collins1 45114 complete blood count (none) mean RBC corpuscular volume (MCV)   [fL]  MCV CC pre w/CC8 139 m 10-14wks N=1
    Collins1 45115 complete blood count (none) hemoglobin (HGB)   [g/dL]  HGB CC pre w/CC8 139 m 10-14wks N=1
    Collins1 45116 complete blood count (none) platelet count (PLT; per volume x 103)   [n/µL]  PLT CC pre w/CC8 139 m 10-14wks N=1
    Collins1 45117 complete blood count (none) mean platelet volume (MPV)   [fL]  MPV CC pre w/CC8 139 m 10-14wks N=1
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