Cheverud1: Diet-induced obesity and diabetes in 19 LGXSM recombinant inbred strains of mice (2004)

Cheverud JM, Ehrich TH, Kenney JP, Pletscher LS, Semenkovich CF. Genetic evidence for discordance between obesity- and diabetes-related traits in the LGXSM recombinant inbred mouse strains. Diabetes. 2004 Oct;53(10):2700-8.   PubMed 15448104  

Hrbek T, de Brito RA, Wang B, Pletscher LS, Cheverud JM. Genetic characterization of a new set of recombinant inbred lines (LGXSM) formed from the inter-cross of SM/J and LG/J inbred mouse strains. Mamm Genome. 2006 May;17(5):417-29.   PubMed 16688532  


         
Notes
Genotypic data (Mit markers) for QTL analysis are available in the supplemental file.

Static graphs are available for the glucose clearance tests.


Cheverud1 downloads
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Participants James M Cheverud       Washington University School of Medicine St. Louis, MO
With: Hrbek T, de Brito RA, Wang B, Pletscher LS, Ehrich TH, Kenney JP, Semenkovich CF
ContactJames M Cheverud     cheverud@pcg.wustl.edu     Lab web site
AcknowledgementsFunding provided by NIH DK55736, DK52514, HL58427, RR15116, DK56431, DK20579
Project type Phenotype strain survey data set
MPD identifiersCheverud1     MPD:178
Data changelog No updates/corrections.       Initial release date: 11/2008.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
There were 2 cohorts: 1) controls on standard diet; and 2) mice fed a high fat diet (42% calories from fat).

Summary of procedures that were conducted
• body weight Body weight and growth curve from age 1wk to 22wks (pre-wean, post-wean, adult). High-fat diet (17wks) vs. control.
• fat pad weights High-fat diet (17wks) vs. control.
• glucose tolerance High-fat diet (17wks) vs. control. 0 to 120 min after 10% glucose i.p. 4h fast.
• lipid profile Cholesterol, triglycerides, free fatty acids. High-fat diet (17wks) vs. control. 4h fast, serum.
• organ weights Heart, liver, kidney, spleen weights after high-fat diet (17wks) vs. control.
• hormone quantification Insulin, leptin.
Mice: LGXSM   19 strains including progenitors   ♀♂   age 12-16wks   2 cohorts

Select table page: First Prev Next Last
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Cheverud1 17801 body weight (none) body weight / growth curve, control diet   [g]     age (wks):    4    5    6    7    9    11    15    19    23 LGXSM w/par 17 both None N=8
    Cheverud1 17814 body weight (none) pre-weaning (1-3 wks) growth rate   [g/wk]     control group    high-fat diet group LGXSM w/par 16 both 1-3wks N=9
    Cheverud1 17815 body weight high fat diet growth rate   [g/wk]     post-weaning (4-10wks):    control diet    high-fat diet LGXSM w/par 16 both None N=8
    Cheverud1 17816 body weight high fat diet growth rate   [g/wk]     adult (11-20wks):    control diet    high-fat diet LGXSM w/par 15 both None N=8
    Cheverud1 17820 organ weights high fat diet kidney weight (both) as percent of body weight   [%]     control diet    high-fat diet LGXSM w/par 16 both 20-30wks N=8
    Cheverud1 17821 organ weights high fat diet heart weight as percent of body weight   [%]     control diet    high-fat diet LGXSM w/par 16 both 20-30wks N=8
    Cheverud1 17822 organ weights high fat diet spleen weight as percent of body weight   [%]     control diet    high-fat diet LGXSM w/par 16 both 20-30wks N=8
    Cheverud1 17823 organ weights high fat diet liver weight as percent of body weight   [%]     control diet    high-fat diet LGXSM w/par 16 both 20-30wks N=8
    Cheverud1 17824 fat pad weights high fat diet gonadal fat pad weight   [g]     control diet    high-fat diet LGXSM w/par 16 both 20-30wks N=8
    Cheverud1 17825 fat pad weights high fat diet perirenal fat pad weight   [g]     control diet    high-fat diet LGXSM w/par 16 both 20-30wks N=8
    Cheverud1 17826 fat pad weights high fat diet mesenteric fat pad weight   [g]     control diet    high-fat diet LGXSM w/par 16 both 20-30wks N=8
    Cheverud1 17827 fat pad weights high fat diet inguinal fat pad weight   [g]     control diet    high-fat diet LGXSM w/par 16 both 20-30wks N=8
    Cheverud1 17828 fat pad weights high fat diet total fat pad weight   [g]     control diet    high-fat diet LGXSM w/par 16 both 20-30wks N=8
    Cheverud1 17829 fat pad weights high fat diet gonadal fat pad weight as pecent of body weight   [%]     control diet    high-fat diet LGXSM w/par 16 both 20-30wks N=8
    Cheverud1 17830 fat pad weights high fat diet perirenal fat pad weight as pecent of body weight   [%]     control diet    high-fat diet LGXSM w/par 16 both 20-30wks N=8
    Cheverud1 17831 fat pad weights high fat diet mesenteric fat pad weight as pecent of body weight   [%]     control diet    high-fat diet LGXSM w/par 16 both 20-30wks N=8
    Cheverud1 17832 fat pad weights high fat diet inquinal fat pad weight as pecent of body weight   [%]     control diet    high-fat diet LGXSM w/par 16 both 20-30wks N=8
    Cheverud1 17833 fat pad weights high fat diet total fat pad weight as pecent of body weight   [%]     control diet    high-fat diet LGXSM w/par 16 both 20-30wks N=8
    Cheverud1 17840 hormone quantification high fat diet insulin (serum)   [ng/mL]     control diet    high-fat diet LGXSM w/par 15 both 20-30wks N=8
    Cheverud1 17841 hormone quantification high fat diet leptin (serum)   [pg/mL]     control diet    high-fat diet LGXSM w/par 9 both 20-30wks N=6
    Cheverud1 17842 lipid profile high fat diet total cholesterol (serum CHOL)   [mg/dL]     control diet    high-fat diet LGXSM w/par 15 both 20-30wks N=8
    Cheverud1 17843 lipid profile high fat diet free fatty acid (serum FFA)   [mg/dL]     control diet    high-fat diet LGXSM w/par 15 both 20-30wks N=8
    Cheverud1 17844 lipid profile high fat diet triglycerides (serum TG, 4h fast)   [mg/dL]     control diet    high-fat diet LGXSM w/par 15 both 20-30wks N=8
    Cheverud1 17845 glucose tolerance high fat diet glucose levels, area under curve, glucose tolerance test
(serum GLU, 10% glucose i.p., 4h fast)   [AUC]
    control diet    high-fat diet
LGXSM w/par 16 both 10wks N=8
    Cheverud1 17846 glucose tolerance high fat diet glucose levels, area under curve, glucose tolerance test
(serum GLU, 10% glucose i.p., 4h fast)   [AUC]
    control diet    high-fat diet
LGXSM w/par 15 both 20wks N=8
    Cheverud1 17851 body weight high fat diet body weight / growth curve, high-fat diet   [g]     age (wks):    4    5    6    7    9    11    15    19    23 LGXSM w/par 18 both None N=8
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