Chesler4: Behavioral and nociception traits in a Diversity Outbred (DO) mouse population and 8 founder inbred strains (2013)

Logan RW, Robledo RF, Recla JM, Philip VM, Bubier JA, Jay JJ, Harwood C, Wilcox T, Gatti DM, Bult CJ, Churchill GA, Chesler EJ. High-precision genetic mapping of behavioral traits in the diversity outbred mouse population. Genes Brain Behav. 2013 Jun;12(4):424-37. doi: 10.1111/gbb.12029. Epub 2013 Mar 20.   PubMed 23433259  

Recla JM, Robledo RF, Gatti DM, Bult CJ, Churchill GA, Chesler EJ. Precise genetic mapping and integrative bioinformatics in Diversity Outbred mice reveals Hydin as a novel pain gene. Mamm Genome. 2014 Jun;25(5-6):211-22. doi: 10.1007/s00335-014-9508-0. Epub 2014 Apr 5.   PubMed 24700285     FullText


       
Chesler4 downloads
• Download Chesler4 project data set     one row per animal, one column per trait
• Download Chesler4 strain means, SD, N, etc.     one row per strain/sex/measure
• Chesler4 supplementary data
Participants Ryan W Logan       The Jackson Laboratory Bar Harbor, ME
Raymond F Robledo       The Jackson Laboratory Bar Harbor, ME
Jill M Recla       The Jackson Laboratory Bar Harbor, ME
Elissa J Chesler       The Jackson Laboratory Bar Harbor, ME
With: Philip VM, Bubier JA, Jay JJ, Harwood C, Wilcox T, Gatti DM, Bult CJ, Churchill GA
ContactElissa J Chesler     elissa.chesler@jax.org     Lab web site
AcknowledgementsFunding provided by NIH GM076468, AG038070
Project type Phenotype strain survey data set
MPD identifiersChesler4     MPD:470
Data changelog No updates/corrections.       Initial release date: 06/2013.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
• Correlations matrix for all measurements . See also QTL project Recla1 which includes a genotype component.

Summary of procedures that were conducted
• open field test Locomotor activity, exploratory, anxiety-related behavior. 20 min test.
• visual cliff Anxiety, avoidance behavior. 20 min test.
• light-dark box Anxiety, avoidance behavior. 20 min test.
• tail suspension test Frequency climbing, time immobile, latency immobile. 5 min test.
• nociception assay Hot plate.
• body weight
Mice: DO population   9 strains including progenitors   ♀♂   age 12-16wks   1 cohort

Select table page: First Prev Next Last
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Chesler4 47001 open field test (none) distance traveled in first 4 min (response to novelty), 20 min test   [cm]  OF_distance_first4 DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47002 open field test (none) total distance traveled, 20 min test   [cm]  OF_distance DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47003 open field test (none) percent time in corners, 20 min test   [%]  OF_corner_pct DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47004 open field test (none) percent time in periphery, 20 min test   [%]  OF_periphery_pct DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47005 open field test (none) percent time immobile, 20 min test   [%]  OF_immobile_pct DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47006 open field test (none) percent time in center, 20 min test   [%]  OF_center_pct DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47007 light-dark box (none) distance traveled in light compartment, 20 min test   [cm]  LD_distance_light DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47008 light-dark box (none) number of light-dark transitions, 20 min test   [n]  LD_transitions DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47009 light-dark box (none) time in light compartment first 4 min (response to novelty), 20 min test   [s]  LD_light_first4 DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47010 light-dark box (none) percent time in light compartment, 20 min test   [%]  LD_light_pct DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47011 visual cliff (none) distance traveled in top during first 4 min (response to novelty), 20 min test   [cm]  VC_top_distance_first4 DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47012 visual cliff (none) time in top during first 4 min (response to novelty), 20 min test   [s]  VC_top_time_first4 DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47013 visual cliff (none) total distance traveled in top, 20 min test   [cm]  VC_top_distance DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47014 visual cliff (none) percent time in top, 20 min test   [%]  VC_top_time_pct DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47015 visual cliff (none) mean velocity in top, 20 min test   [cm/s]  VC_top_velocity DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47016 visual cliff (none) distance traveled in bottom during first 4 min (response to novelty), 20 min test   [cm]  VC_bottom_distance_first4 DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47017 visual cliff (none) time in bottom during first 4 min (response to novelty), 20 min test   [s]  VC_bottom_time_first4 DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47018 visual cliff (none) total distance traveled in bottom, 20 min test   [cm]  VC_bottom_distance DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47020 visual cliff (none) percent time in bottom, 20 min test   [%]  VC_bottom_time_pct DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47021 visual cliff (none) mean velocity in bottom, 20 min test   [cm/s]  VC_bottom_velocity DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47022 visual cliff (none) number of top to bottom transitions, 20 min test   [n]  VC_bottom_transitions DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47024 nociception assay (none) latency of hindpaw withdrawal, 55°C heat stimulation   [s]  HP_latency DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47026 tail suspension test (none) average frequency climbing, 5 min test   [n]  TS_frequency_climbing DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47027 tail suspension test (none) average time immobile, 5 min test   [s]  TS_time_immobile DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47028 tail suspension test (none) average latency to first immobility episode, 5 min test   [s]  TS_latency_immobile DO population w/CC8 9 both 12-16wks N=8
    Chesler4 47029 body weight (none) body weight at dissection   [g]  bw DO population w/CC8 9 both 12-16wks N=8
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