Brugnara1: Erythrocyte cation content and transport in 10 inbred strains of mice (2013)

Rivera A, Zee RY, Alper SL, Peters LL, Brugnara C. Strain-specific variations in cation content and transport in mouse erythrocytes. Physiol Genomics. 2013 May 1;45(9):343-50. doi: 10.1152/physiolgenomics.00143.2012. Epub 2013 Mar 12.   PubMed 23482811  


       
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Participants Carlo Brugnara       Harvard Medical School Boston, MA
Luanne L Peters       The Jackson Laboratory Bar Harbor, ME
With: Rivera A, Zee RY, Alper SL
ContactCarlo Brugnara     Carlo.Brugnara@childrens.harvard.edu
AcknowledgementsFunding provided by NIH HL085480, HL081497, HL090632, CA34196
Project type Phenotype strain survey data set
MPD identifiersBrugnara1     MPD:474
Data changelog No updates/corrections.       Initial release date: 05/2013.
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Summary of procedures that were conducted
• complete blood count Hematology.
• ion transport assessment Hematology red cell ion content, ion transport.
Mice: inbred   10 strains   ♀♂   age 8wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Brugnara1 47401 ion transport assessment (none) RBC sodium cation content (mmol/kg hemoglobin)   [mmol/kg]  sodium inbred 10 both 8wks N=31
    Brugnara1 47402 ion transport assessment (none) RBC potassium cation content (mmol/kg hemoglobin)   [mmol/kg]  potassium inbred 10 both 8wks N=31
    Brugnara1 47403 ion transport assessment (none) RBC magnesium cation content (mmol/kg hemoglobin)   [mmol/kg]  magnesium inbred 10 both 8wks N=28
    Brugnara1 47404 ion transport assessment (none) RBC potassium chloride cotransport (KCC; per 1013 cells)   [mmol⋅h]  K_Cl inbred 10 both 8wks N=14
    Brugnara1 47405 ion transport assessment (none) RBC sodium-potassium pump (Na-K; per 1013 cells)   [mmol⋅h]  Na_K_pump inbred 10 both 8wks N=11
    Brugnara1 47406 ion transport assessment (none) RBC sodium-hydrogen exchanger (NHE1; per 1013 cells)   [mmol⋅h]  Na_H_exchange inbred 10 both 8wks N=10
    Brugnara1 47407 ion transport assessment (none) RBC calcium-activated potassium channel (KCNN4)   [mmol/L⋅min]  gardos_channel inbred 10 both 8wks N=11
    Brugnara1 47408 complete blood count (none) mean RBC corpuscular volume (MCV)   [fL]  MCV inbred 10 both 8wks N=31
    Brugnara1 47409 complete blood count (none) RBC corpuscular hemoglobin concentration mean (CHCM)   [g/dL]  CHCM inbred 10 both 8wks N=33
    Brugnara1 47410 complete blood count (none) mean RBC corpuscular hemoglobin conent (MCH)   [pg]  MCH inbred 10 both 8wks N=31
    Brugnara1 47411 complete blood count (none) reticulocyte differential (percent of total RBC)   [%]  retic inbred 10 both 8wks N=30
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