Boon1: Susceptibility to influenza A (H5N1) viral infection in females of 23 strains of mice (2011)

Boon AC, Finkelstein D, Zheng M, Liao G, Allard J, Klumpp K, Webster R, Peltz G, Webby RJ. H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load. MBio. 2011 Sep 6;2(5). pii: e00171-1doi: 10.1128/mBio.00171-1Print 2011.   PubMed 21896679     FullText


       
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Participants Adrianus CM Boon       Washington University School of Medicine St. Louis, MO
Richard J Webby       St. Jude Children's Research Hospital Memphis, TN
With: Finkelstein D, Zheng M, Liao G, Allard J, Klumpp K, Webster R, Peltz G
ContactAdrianus CM Boon     JBOON@DOM.wustl.edu     Lab web site
AcknowledgementsFunding provided by the National Institute of Allergy and Infectious Diseases, U.S. Department of Health and Human Services (contract no. HHSN266200700005C); American Lebanese Syrian Associated Charities (ALSAC)
Project type Phenotype strain survey data set
MPD identifiersBoon1     MPD:469
Data changelog No updates/corrections.       Initial release date: 04/2013.
Formatted citation
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Summary of procedures that were conducted
• body weight Influenza A (H5N1) virus (several doses) vs. baseline.
• health assessment Survival rate, influenza A (H5N1) virus (several doses). Strain H5N1 susceptibility score.
Mice: inbred   23 strains   ♀   age 6-9wks   3 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Boon1 46901 body weight (none) body weight, pre-infection   [g]     dosage group:    low    medium    high inbred 18 f 6-9wks N=11
    Boon1 46911 body weight influenza A (H5N1) virus change in body weight, post-infection   [%]     dosage group:    low    medium    high inbred 18 f 6-9wks N=11
    Boon1 46921 health assessment influenza A (H5N1) virus survival   [d]     dosage group:    low    medium    high inbred 18 f 6-9wks N=11
    Boon1 46931 health assessment influenza A (H5N1) virus susceptibility to viral infection   [designation]     dosage group:    low    medium    high inbred 18 f 6-9wks N=11
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