Bennett3: Drug study: Acute functional tolerance to ethanol in 74 ILSXISS recombinant inbred strains of mice (2007)

Bennett B, Downing C, Carosone-Link P, Ponicsan H, Ruf C, Johnson TE. Quantitative trait locus mapping for acute functional tolerance to ethanol in the L x S recombinant inbred panel. Alcohol Clin Exp Res. 2007 Feb;31(2):200-8.   PubMed 17250610  


       
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Participants Beth Bennett       University of Colorado Denver School of Medicine Aurora, CO
Thomas E Johnson       University of Colorado Boulder, CO
With: Downing C, Carosone-Link P, Ponicsan H, Ruf C
ContactBeth Bennett     Beth.Bennett@ucdenver.edu     Lab web site
AcknowledgementsFunding provided by NIH AA11984, AA08940
Project type Phenotype strain survey data set
MPD identifiersBennett3     MPD:375
Data changelog No updates/corrections.       Initial release date: 07/2011.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Alcohol sensitivity and acute alcohol tolerance were studied in a single cohort of mice using a test of ataxia: loss and regain of balance on a stationary wooden dowel upon exposure to two doses of EtOH within the same testing session.

Summary of procedures that were conducted
• alcohol quantification Blood alcohol concentrations after ethanol injection over time, acute functional ethanol tolerance.
Mice: ILSXISS   74 strains including progenitors   ♀♂   age 8-14wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Bennett3 37501 alcohol quantification ethanol blood ethanol concentration (BEC)   [mg/mL]     first loss of balance (ataxia)    first regain of balance    second regain of balance ILSXISS w/par 72 both 8-14wks N=5
    Bennett3 37504 alcohol quantification ethanol acute functional tolerance to EtOH (AFT1 = BEC 2 minus BEC 1)   [mg/mL]  AFT1 ILSXISS w/par 72 both 8-14wks N=5
    Bennett3 37505 alcohol quantification ethanol acute functional tolerance to EtOH (AFT2 = BEC 2 minus BEC 0)   [mg/mL]  AFT2 ILSXISS w/par 72 both 8-14wks N=5
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