Procedure:   drug and metabolite quantification          


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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg) Year
    Crabbe2 15501 drug and metabolite quantification diazepam brain diazepam and metabolite concentration (30 min post-injection)   [ng/g]     8 mg/kg    16 mg/kg inbred 15 m 6-7wks N=8 1998
    Crabbe2 15503 drug and metabolite quantification diazepam brain diazepam and metabolite concentration (<5 min post-injection)
after rotarod   [ng/g]
    trial block1    trial block2
inbred 8 m 6-7wks N=13 1998
    Crowley1 39403 drug and metabolite quantification haloperidol plasma haloperidol concentration   [nM]     day:    30    60    90    120 inbred w/CC8 27 m 9-28wks N=6 2012
    Gould1 37405 drug and metabolite quantification lithium serum lithium concentration   [mmol/L]     lithium dose [mg/kg]:    200    300    400 inbred 11 m 7-8wks N=8 2011
    Gould1 37408 drug and metabolite quantification lithium brain lithium concentration   [mmol/L]     lithium dose [mg/kg]:    200    300    400 inbred 11 m 7-8wks N=8 2011
    Gould2 47101 drug and metabolite quantification nicotine plasma nicotine   [ng/mL]     acute 0.09mg dose    chronic 6.3mg dose inbred 8 m 8-12wks N=10 2011
    Gould2 47105 drug and metabolite quantification nicotine plasma cotinine   [ng/mL]     acute 0.09mg dose    chronic 6.3mg dose inbred 8 m 8-12wks N=10 2011
    Harrill2 44155 drug and metabolite quantification DB289 kidney metabolite (DB75) concentration   [µM]     control    DB289 inbred 23 f 6-8wks N=4 2012
    Rusyn2 36167 drug and metabolite quantification trichloroethylene dichloroacetic acid (serum DCA x 10-3)   [nmol/mL]     treated group:    2h    8h    24h inbred 15 m 7wks N=3 2010
    Rusyn2 36175 drug and metabolite quantification trichloroethylene trichloroacetic acid (serum TCA)   [nmol/mL]     treated group:    2h    8h    24h inbred 15 m 7wks N=3 2010
    Rusyn2 36185 drug and metabolite quantification trichloroethylene DCV cysteine (serum DCVC x 10-3)   [nmol/mL]     treated group:    2h    8h    24h inbred 15 m 7wks N=2 2010
    Rusyn2 36195 drug and metabolite quantification trichloroethylene DCV glutathione (serum DCVG x 10-3)   [nmol/mL]     treated group:    2h    8h    24h inbred 15 m 7wks N=2 2010
    Rusyn6 51202 drug and metabolite quantification trichloroethylene trichloroacetic acid (serum TCA)   [nmol/mL]  TCA_serum_tce inbred 7 m 6-7wks N=3 2014
    Rusyn6 51204 drug and metabolite quantification trichloroethylene dichloroacetic acid (serum DCA)   [nmol/mL]  DCA_serum_tce inbred 7 m 6-7wks N=3 2014
    Rusyn6 51206 drug and metabolite quantification trichloroethylene S-(1,2-dichlorovinyl) glutathione (serum DCVG)   [pmol/mL]  DCVG_serum_tce inbred 4 m 6-7wks N=2 2014
    Rusyn6 51208 drug and metabolite quantification trichloroethylene S-(1,2-dichlorovinyl)-L-cysteine (serum DCVC)   [pmol/mL]  DCVC_serum_tce inbred 7 m 6-7wks N=3 2014
    Rusyn6 51216 drug and metabolite quantification trichloroethylene trichloroacetic acid (liver TCA)   [nmol/g]  TCA_liver_tce inbred 7 m 6-7wks N=4 2014
    Rusyn6 51218 drug and metabolite quantification trichloroethylene dichloroacetic acid (liver DCA)   [nmol/g]  DCA_liver_tce inbred 7 m 6-7wks N=4 2014
    Rusyn6 51220 drug and metabolite quantification trichloroethylene trichloroethanol (liver TCOH)   [nmol/g]  TCOH_liver_tce inbred 7 m 6-7wks N=4 2014
    Rusyn6 51222 drug and metabolite quantification trichloroethylene S-(1,2-dichlorovinyl) glutathione (liver DCVG)   [pmol/g]  DCVG_liver_tce inbred 7 m 6-7wks N=4 2014
    Rusyn6 51258 drug and metabolite quantification trichloroethylene trichloroacetic acid (kidney TCA)   [nmol/g]  TCA_kidney_tce inbred 7 m 6-7wks N=4 2014
    Rusyn6 51260 drug and metabolite quantification trichloroethylene dichloroacetic acid (kidney DCA)   [nmol/g]  DCA_kidney_tce inbred 6 m 6-7wks N=3 2014
    Rusyn6 51262 drug and metabolite quantification trichloroethylene trichloroethanol (kidney TCOH)   [nmol/g]  TCOH_kidney_tce inbred 7 m 6-7wks N=4 2014
    Rusyn6 51264 drug and metabolite quantification trichloroethylene S-(1,2-dichlorovinyl) glutathione (kidney DCVG)   [pmol/g]  DCVG_kidney_tce inbred 6 m 6-7wks N=3 2014
    Rusyn6 51266 drug and metabolite quantification trichloroethylene S-(1,2-dichlorovinyl)-L-cysteine (kidney DCVC)   [pmol/g]  DCVC_kidney_tce inbred 6 m 6-7wks N=3 2014
    Threadgill2 39609 drug and metabolite quantification acetaminophen serum acetaminophen (APAP)   [µg/mL]     baseline    0.5h    1h    2h    3h    6h inbred 5 m 6-8wks N=5 2005
    Threadgill2 39616 drug and metabolite quantification acetaminophen serum acetaminophen sulfate (APAP-sulfate)   [µg/mL]     baseline    0.5h    1h    2h    3h    6h inbred 5 m 6-8wks N=5 2005
    Threadgill2 39622 drug and metabolite quantification acetaminophen serum acetaminophen glucuronide (APAP-Glc)   [µg/mL]     baseline    0.5h    1h    2h    3h    6h inbred 5 m 6-8wks N=4 2005
    Threadgill2 39632 drug and metabolite quantification acetaminophen serum acetaminophen (APAP)   [µg/mL]     baseline    0.5h    1h    2h    3h    6h inbred 5 m 6-8wks N=5 2005
    Threadgill2 39638 drug and metabolite quantification acetaminophen serum acetaminophen sulfate (APAP-sulfate)   [µg/mL]     baseline    0.5h    1h    2h    3h    6h inbred 5 m 6-8wks N=5 2005
    Threadgill2 39639 drug and metabolite quantification acetaminophen serum acetaminophen glucuronide (APAP-Glc)   [µg/mL]     baseline    0.5h    1h    2h    3h    6h inbred 5 m 6-8wks N=5 2005
    Wiltshire2 38007 drug and metabolite quantification fluoxetine drug and metabolite concentration   [ng/mL]     fluoxetine    norfluoxetine inbred 30 m 10-11wks N=11 2011
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