MPD: Project measures / variables set: Berndt2 resp

Project measures / variables set: Berndt2 resp_flow

ID, description, units	MPD:35154 resp_flow respiratory flow rate [mL/kg/s] methacholine study
Measures	• saline • 5 MCh • 10 MCh • 20 MCh • response index
Data set, strains	Berndt2 inbred 29 strains sex: both age: 9-12wks
Procedure	plethysmography
Comparison	repeated measures, baseline then treated multiple doses, same cohort
Ontology mappings	VT:0001943 respiration trait VT:0002338 pulmonary ventilation trait VT:0010487 response to xenobiotic stimulus trait MA:0000415 lung MP:0001951 abnormal breathing pattern MP:0002334 abnormal airway responsiveness MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Berndt2 - respiratory flow rate

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	5.8785	5.8785	40.6588	< 0.0001
between strain	28	118.519	4.2328	29.2764	< 0.0001
between sex:strain	28	7.7704	0.2775	1.9194	0.0038
between Residuals	412	59.5675	0.1446
within group	3	18.73	6.2433	113.4395	< 0.0001
within group:sex	3	0.5298	0.1766	3.2086	0.0224
within group:strain	84	40.2959	0.4797	8.7163	< 0.0001
within group:sex:strain	84	7.0761	0.0842	1.5306	0.0019
within Residuals	1236	68.0252	0.055

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Berndt2	35154	plethysmography	methacholine	respiratory flow rate [mL/kg/s] saline resp_flow_saline	inbred	29	both	9-12wks
Berndt2	35155	plethysmography	methacholine	respiratory flow rate [mL/kg/s] 5 MCh resp_flow_mch5	inbred	29	both	9-12wks
Berndt2	35156	plethysmography	methacholine	respiratory flow rate [mL/kg/s] 10 MCh resp_flow_mch10	inbred	29	both	9-12wks
Berndt2	35157	plethysmography	methacholine	respiratory flow rate [mL/kg/s] 20 MCh resp_flow_mch20	inbred	29	both	9-12wks
Berndt2	35158	plethysmography	methacholine	respiratory flow rate [mL/kg/s] response index resp_flow_slope	inbred	29	both	9-12wks	(supplemental / summary measure)