MPD: Project measures / variables set: Berndt2 duty

Project measures / variables set: Berndt2 duty_cycle

ID, description, units	MPD:35134 duty_cycle duty cycle [ratio] methacholine study
Measures	• saline • 5 MCh • 10 MCh • 20 MCh • response index
Data set, strains	Berndt2 inbred 29 strains sex: both age: 9-12wks
Procedure	plethysmography
Comparison	repeated measures, baseline then treated multiple doses, same cohort
Ontology mappings	VT:0001943 respiration trait VT:0002338 pulmonary ventilation trait VT:0010487 response to xenobiotic stimulus trait MA:0000415 lung MP:0001951 abnormal breathing pattern MP:0002334 abnormal airway responsiveness MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Berndt2 - duty cycle

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	0.097	0.097	48.184	< 0.0001
between strain	28	1.0643	0.038	18.8839	< 0.0001
between sex:strain	28	0.127	0.0045	2.2529	0.0003
between Residuals	412	0.8293	0.002
within group	3	0.8132	0.2711	343.4212	< 0.0001
within group:sex	3	0.0108	0.0036	4.5744	0.0034
within group:strain	84	0.5256	0.0063	7.9272	< 0.0001
within group:sex:strain	84	0.0949	0.0011	1.4307	0.0079
within Residuals	1236	0.9756	0.0008

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Berndt2	35134	plethysmography	methacholine	duty cycle [ratio] saline duty_cycle_saline	inbred	29	both	9-12wks
Berndt2	35135	plethysmography	methacholine	duty cycle [ratio] 5 MCh duty_cycle_mch5	inbred	29	both	9-12wks
Berndt2	35136	plethysmography	methacholine	duty cycle [ratio] 10 MCh duty_cycle_mch10	inbred	29	both	9-12wks
Berndt2	35137	plethysmography	methacholine	duty cycle [ratio] 20 MCh duty_cycle_mch20	inbred	29	both	9-12wks
Berndt2	35138	plethysmography	methacholine	duty cycle [ratio] response index duty_cycle_slope	inbred	29	both	9-12wks	(supplemental / summary measure)