MPD: Project measures / variables set: Berndt2 expiratory

Project measures / variables set: Berndt2 expiratory

ID, description, units	MPD:35121 expiratory expiratory phase [s] methacholine study
Measures	• saline • 5 MCh • 10 MCh • 20 MCh • response index
Data set, strains	Berndt2 inbred 29 strains sex: both age: 9-12wks
Procedure	plethysmography
Comparison	repeated measures, baseline then treated multiple doses, same cohort
Ontology mappings	VT:0001943 respiration trait VT:0002338 pulmonary ventilation trait VT:0010487 response to xenobiotic stimulus trait MA:0000415 lung MP:0001951 abnormal breathing pattern MP:0002334 abnormal airway responsiveness MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Berndt2 - expiratory phase

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	0.0501	0.0501	10.2463	0.0015
between strain	28	2.7075	0.0967	19.7582	< 0.0001
between sex:strain	28	0.2799	0.01	2.0429	0.0016
between Residuals	412	2.0163	0.0049
within group	3	0.0431	0.0144	6.978	0.0001
within group:sex	3	0.0103	0.0034	1.6598	0.1739
within group:strain	84	1.3167	0.0157	7.6088	< 0.0001
within group:sex:strain	84	0.2214	0.0026	1.2792	0.0499
within Residuals	1236	2.5463	0.0021

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Berndt2	35121	plethysmography	methacholine	expiratory phase [s] saline expiratory_saline	inbred	29	both	9-12wks
Berndt2	35122	plethysmography	methacholine	expiratory phase [s] 5 MCh expiratory_mch5	inbred	29	both	9-12wks
Berndt2	35123	plethysmography	methacholine	expiratory phase [s] 10 MCh expiratory_mch10	inbred	29	both	9-12wks
Berndt2	35124	plethysmography	methacholine	expiratory phase [s] 20 MCh expiratory_mch20	inbred	29	both	9-12wks
Berndt2	35125	plethysmography	methacholine	expiratory phase [s] response index expiratory_slope	inbred	29	both	9-12wks	(supplemental / summary measure)