MPD: Project measures / variables set: Jaxpheno6 pct

Project measures / variables set: Jaxpheno6 pct_CD4

ID, description, units	MPD:23101 pct_CD4 splenic CD4 T cells (percentage of total viable cells) [%]
Measures	• 8wks • 16wks
Data set, strains	Jaxpheno6 inbred 11 strains sex: both
Procedure	immune cell quantification
Comparison	multiple cohorts measured at two age timepoints
Ontology mappings	VT:0000689 spleen morphology trait VT:0008073 CD4-positive T cell quantity MA:0000141 spleen MP:0008073 abnormal CD4-positive, alpha beta T cell number

Values Means Δ Means Z-scores

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Jaxpheno6 - splenic CD4 T cells (percentage of total viable cells)

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
age	1	39.0257	39.0257	7.0055	0.0088
age:sex	1	0.4507	0.4507	0.0809	0.7764
age:sex:strain	5	33.2572	6.6514	1.194	0.3137
age:strain	5	541.7335	108.3467	19.4493	< 0.0001
Residuals	189	1052.8688	5.5707
sex	1	23.3505	23.3505	4.1916	0.042
sex:strain	5	83.6181	16.7236	3.0021	0.0124
strain	5	8891.5842	1778.3168	319.2248	< 0.0001

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Jaxpheno6	23101	immune cell quantification	(none)	splenic CD4 T cells (percentage of total viable cells) [%] at age age 8wks pct_CD4_8	inbred	11	both	8wks
Jaxpheno6	23102	immune cell quantification	(none)	splenic CD4 T cells (percentage of total viable cells) [%] at age age 16wks pct_CD4_16	inbred	8	both	16wks