MPD: Project measures / variables set: Threadgill1 AST

Project measures / variables set: Threadgill1 AST

ID, description, units	MPD:19410 AST aspartate transaminase (serum AST) [IU/L] acetaminophen study
Measures	• dose (mg/kg): control • 100 • 200 • 300
Data set, strains	Threadgill1 inbred w/CC7 37 strains sex: m age: 8-17wks
Procedure	metabolic panel
Comparison	control group vs. multiple treatment / dosage groups
Ontology mappings	VT:0000203 blood aspartate transaminase amount VT:0010487 response to xenobiotic stimulus trait MA:0002502 serum MP:0000203 abnormal circulating aspartate transaminase level MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Threadgill1 - aspartate transaminase (serum AST)

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
dose	3	1355681884.9947	451893961.6649	21.9133	< 0.0001
dose:strain	18	1341394576.2023	74521920.9001	3.6137	0.0001
Residuals	63	1299181743.5	20621932.4365
strain	6	688724715.0612	114787452.5102	5.5663	0.0001

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Threadgill1	19410	metabolic panel	acetaminophen	aspartate transaminase (serum AST) [IU/L] control AST_ctrl	inbred w/CC7	37	m	8-17wks
Threadgill1	19411	metabolic panel	acetaminophen	aspartate transaminase (serum AST) [IU/L] dose: 100 mg/kg AST_Rx100	inbred w/CC7	7	m	8-17wks
Threadgill1	19441	metabolic panel	acetaminophen	aspartate transaminase (serum AST) [IU/L] dose: 200 mg/kg AST_Rx200	inbred w/CC7	8	m	8-17wks
Threadgill1	19471	metabolic panel	acetaminophen	aspartate transaminase (serum AST) [IU/L] dose: 300 mg/kg AST_Rx300	inbred w/CC7	37	m	8-17wks