MPD: Project measures / variables set: Gershenfeld1 TST

Project measures / variables set: Gershenfeld1 TST_Rx

ID, description, units	MPD:16203 TST_Rx TST duration of immobility, treatment group, 6 min test [s] imipramine study
Measures	• baseline • imipramine 30mg/kg
Data set, strains	Gershenfeld1 inbred 12 strains sex: m age: 5-10wks
Procedure	tail suspension test
Comparison	repeated measures, baseline then treated, same cohort
Ontology mappings	VT:0010487 response to xenobiotic stimulus trait VT:0015015 depression-related behavior trait MP:0003360 abnormal depression-related behavior MP:0009745 abnormal behavioral response to xenobiotic

Values Means Δ Means Z-scores

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Gershenfeld1 - TST duration of immobility, treatment group, 6 min test

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between strain	11	94413.5908	8583.0537	6.8474	< 0.0001
between Residuals	50	62673.8286	1253.4766
within group	1	4227.2258	4227.2258	4.4637	0.0396
within group:strain	11	22348.9742	2031.7249	2.1454	0.0336
within Residuals	50	47350.8	947.016

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Gershenfeld1	16203	tail suspension test	imipramine	TST duration of immobility, treatment group, 6 min test [s] baseline TST_preRx	inbred	12	m	5-10wks
Gershenfeld1	16204	tail suspension test	imipramine	TST duration of immobility, treatment group, 6 min test [s] imipramine 30mg/kg TST_postRx	inbred	12	m	5-10wks