Project measure / variable:   Mogil3   allodynia

ID, description, units MPD:48002   allodynia   percentage of maximum hindpaw mechanical allodynia over 28 days after spared nerve injury   [%]  
Data set, strains Mogil3   inbred   18 strains     sex: both     age: 7-12wks
Procedure nociception assay
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  STRAIN COMPARISON PLOT
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Mogil3 - percentage of maximum hindpaw mechanical allodynia over 28 days after spared nerve injury



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested18 strains18 strains
Mean of the strain means75.3   % 64.4   %
Median of the strain means78.4   % 66.7   %
SD of the strain means± 10.8 ± 18.0
Coefficient of variation (CV)0.143 0.279
Min–max range of strain means50.1   –   88.3   % 18.7   –   84.5   %
Mean sample size per strain2.9   mice 2.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 2689.934 2689.934 8.4448 0.005
strain 17 13931.3262 819.4898 2.5727 0.0034
sex:strain 17 5357.054 315.1208 0.9893 0.4811
Residuals 64 20386.0717 318.5324


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 82.6 11.8   3 6.81 0.143 69.4, 92.1 0.67
129S1/SvImJ m 78.2 1.27   2   0.9 0.0163 77.3, 79.1 0.77
A/HeJ f 73.3 11.5   3 6.66 0.157 64.2, 86.3 -0.19
A/HeJ m 77.9 6.51   2   4.6 0.0835 73.3, 82.5 0.75
A/J f 75.5 15.4   3 8.88 0.204 58.6, 88.7 0.01
A/J m 84.5 7.69   3 4.44 0.091 77.3, 92.6 1.12
AKR/J f 77.7 20.6   3 11.9 0.265 54.3, 93.2 0.22
AKR/J m 63.8 3.79   3 2.19 0.0594 59.4, 66.2 -0.03
B10.D2-Hc0 f 50.1 31.4   3 18.1 0.628 21.6, 83.8 -2.35
B10.D2-Hc0 m 40.0 11.0   3 6.35 0.275 30.6, 52.1 -1.36
BALB/cByJ f 70.5 23.6   3 13.6 0.335 43.3, 85.7 -0.45
BALB/cByJ m 72.4 9.68   3 5.59 0.134 61.5, 79.9 0.44
BALB/cJ f 88.3 6.86   2   4.85 0.0776 83.5, 93.2 1.2
BALB/cJ m 81.8 0.99   2   0.7 0.0121 81.1, 82.5 0.97
BUB/BnJ f 86.0 10.6   3 6.12 0.123 75.3, 96.5 0.99
BUB/BnJ m 72.4 26.2   3 15.1 0.362 42.3, 90.1 0.44
C3H/HeJ f 78.3 10.2   3 5.86 0.13 69.7, 89.5 0.27
C3H/HeJ m 18.7 0.0   2   0.0 0.0 18.7, 18.7 -2.54
C57BL/6J f 80.5 7.25   3 4.19 0.09 76.1, 88.9 0.48
C57BL/6J m 62.3 22.9   3 13.2 0.367 38.7, 84.4 -0.12
DBA/2J f 54.7 44.0   3 25.4 0.804 6.4, 92.4 -1.92
DBA/2J m 50.6 42.6   3 24.6 0.842 3.0, 85.1 -0.77
FVB/NJ f 80.9 6.08   2   4.3 0.0752 76.6, 85.2 0.52
FVB/NJ m 67.3 33.4   2   23.6 0.496 43.7, 90.9 0.16
LG/J f 78.7 7.85   3 4.53 0.0998 69.7, 84.3 0.31
LG/J m 80.0 7.16   3 4.13 0.0895 73.9, 87.9 0.87
LP/J f 84.3 5.31   3 3.06 0.063 78.6, 89.1 0.83
LP/J m 64.1 9.0   3 5.2 0.14 55.2, 73.2 -0.02
MRL/MpJ f 87.2 7.21   2   5.1 0.0827 82.1, 92.3 1.1
MRL/MpJ m 83.3 12.1   3 6.96 0.145 72.0, 96.0 1.05
NZB/BlNJ f 78.5 7.07   3 4.08 0.0902 70.3, 82.7 0.29
NZB/BlNJ m 59.8 27.2   3 15.7 0.456 28.4, 77.5 -0.26
NZW/LacJ f 65.1 2.55   3 1.47 0.0392 62.5, 67.6 -0.95
NZW/LacJ m 66.0 3.43   3 1.98 0.052 62.9, 69.7 0.09
SM/J f 64.1 14.7   3 8.5 0.23 47.5, 75.6 -1.04
SM/J m 36.5 12.5   3 7.21 0.342 27.8, 50.8 -1.55


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 82.6 10.3042 103.1851 62.0149
129S1/SvImJ m 78.2 12.6201 103.4115 52.9885
A/HeJ f 73.3333 10.3042 93.9184 52.7482
A/HeJ m 77.9 12.6201 103.1115 52.6885
A/J f 75.5 10.3042 96.0851 54.9149
A/J m 84.5 10.3042 105.0851 63.9149
AKR/J f 77.7333 10.3042 98.3184 57.1482
AKR/J m 63.7667 10.3042 84.3518 43.1816
B10.D2-Hc0 f 50.0667 10.3042 70.6518 29.4816
B10.D2-Hc0 m 40.0 10.3042 60.5851 19.4149
BALB/cByJ f 70.5333 10.3042 91.1184 49.9482
BALB/cByJ m 72.4333 10.3042 93.0184 51.8482
BALB/cJ f 88.35 12.6201 113.5615 63.1385
BALB/cJ m 81.8 12.6201 107.0115 56.5885
BUB/BnJ f 86.0333 10.3042 106.6184 65.4482
BUB/BnJ m 72.4 10.3042 92.9851 51.8149
C3H/HeJ f 78.3 10.3042 98.8851 57.7149
C3H/HeJ m 18.7 12.6201 43.9115 0.0
C57BL/6J f 80.5333 10.3042 101.1184 59.9482
C57BL/6J m 62.3 10.3042 82.8851 41.7149
DBA/2J f 54.7333 10.3042 75.3184 34.1482
DBA/2J m 50.5667 10.3042 71.1518 29.9816
FVB/NJ f 80.9 12.6201 106.1115 55.6885
FVB/NJ m 67.3 12.6201 92.5115 42.0885
LG/J f 78.6667 10.3042 99.2518 58.0816
LG/J m 80.0333 10.3042 100.6184 59.4482
LP/J f 84.3 10.3042 104.8851 63.7149
LP/J m 64.1333 10.3042 84.7184 43.5482
MRL/MpJ f 87.2 12.6201 112.4115 61.9885
MRL/MpJ m 83.3 10.3042 103.8851 62.7149
NZB/BlNJ f 78.4667 10.3042 99.0518 57.8816
NZB/BlNJ m 59.7667 10.3042 80.3518 39.1816
NZW/LacJ f 65.1 10.3042 85.6851 44.5149
NZW/LacJ m 66.0333 10.3042 86.6184 45.4482
SM/J f 64.1 10.3042 84.6851 43.5149
SM/J m 36.5 10.3042 57.0851 15.9149


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 80.4 8.1462 96.6739 64.1261
A/HeJ both 75.6167 8.1462 91.8906 59.3427
A/J both 80.0 7.2862 94.5559 65.4441
AKR/J both 70.75 7.2862 85.3059 56.1941
B10.D2-Hc0 both 45.0333 7.2862 59.5892 30.4775
BALB/cByJ both 71.4833 7.2862 86.0392 56.9275
BALB/cJ both 85.075 8.9237 102.9022 67.2478
BUB/BnJ both 79.2167 7.2862 93.7725 64.6608
C3H/HeJ both 48.5 8.1462 64.7739 32.2261
C57BL/6J both 71.4167 7.2862 85.9725 56.8608
DBA/2J both 52.65 7.2862 67.2059 38.0941
FVB/NJ both 74.1 8.9237 91.9272 56.2728
LG/J both 79.35 7.2862 93.9059 64.7941
LP/J both 74.2167 7.2862 88.7725 59.6608
MRL/MpJ both 85.25 8.1462 101.5239 68.9761
NZB/BlNJ both 69.1167 7.2862 83.6725 54.5608
NZW/LacJ both 65.5667 7.2862 80.1225 51.0108
SM/J both 50.3 7.2862 64.8559 35.7441




  GWAS USING LINEAR MIXED MODELS