Project measure / variable:   Donahue9   LDH

ID, description, units MPD:41812   LDH   lactate dehydrogenase (serum LDH)   [U/L]  
Data set, strains Donahue9   B6.PWD consomic w/par   25 strains     sex: both     age: 11wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Donahue9 - lactate dehydrogenase (serum LDH)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested23 strains25 strains
Mean of the strain means1555   U/L 1637   U/L
Median of the strain means1532   U/L 1667   U/L
SD of the strain means± 223 ± 214
Coefficient of variation (CV)0.143 0.131
Min–max range of strain means1054   –   2138   U/L 1240   –   2032   U/L
Mean sample size per strain7.5   mice 7.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 465871.6578 465871.6578 3.3862 0.0667
strain 22 12080271.2837 549103.2402 3.9912 < 0.0001
sex:strain 22 2625633.6408 119346.9837 0.8675 0.6385
Residuals 305 41961701.6115 137579.3495


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6.PWD-Chr1 f 1425.0 327.0   7 124.0 0.229 842.0, 1813.0 -0.58
B6.PWD-Chr1 m 1687.0 552.0   7 209.0 0.327 878.0, 2176.0 0.23
B6.PWD-Chr10.1 f 2138.0 190.0   6 77.8 0.0891 1827.0, 2347.0 2.62
B6.PWD-Chr10.1 m 1835.0 408.0   8 144.0 0.222 1061.0, 2250.0 0.92
B6.PWD-Chr10.2 f 1617.0 391.0   10 124.0 0.242 919.0, 2141.0 0.28
B6.PWD-Chr10.2 m 1501.0 321.0   10 102.0 0.214 1117.0, 2004.0 -0.63
B6.PWD-Chr10.3 f 1787.0 374.0   6 153.0 0.209 1325.0, 2250.0 1.04
B6.PWD-Chr10.3 m 1786.0 268.0   8 94.7 0.15 1384.0, 2291.0 0.7
B6.PWD-Chr11.1 f 1748.0 382.0   12 110.0 0.219 1005.0, 2188.0 0.87
B6.PWD-Chr11.1 m 1794.0 300.0   12 86.7 0.167 1402.0, 2250.0 0.73
B6.PWD-Chr11.2 f 1532.0 466.0   9 155.0 0.304 878.0, 2282.0 -0.1
B6.PWD-Chr11.2 m 1650.0 617.0   9 206.0 0.374 531.0, 2316.0 0.06
B6.PWD-Chr11.3 f 1522.0 378.0   9 126.0 0.249 1124.0, 2236.0 -0.15
B6.PWD-Chr11.3 m 1298.0 165.0   8 58.4 0.127 1130.0, 1618.0 -1.58
B6.PWD-Chr12 f 1435.0 391.0   8 138.0 0.273 830.0, 1957.0 -0.54
B6.PWD-Chr12 m 1531.0 297.0   8 105.0 0.194 1279.0, 2182.0 -0.49
B6.PWD-Chr14 f 1725.0 319.0   7 120.0 0.185 1244.0, 2301.0 0.77
B6.PWD-Chr14 m 1881.0 342.0   8 121.0 0.182 1404.0, 2370.0 1.14
B6.PWD-Chr15 f 1418.0 396.0   8 140.0 0.279 910.0, 2271.0 -0.61
B6.PWD-Chr15 m 1682.0 329.0   8 116.0 0.196 1268.0, 2221.0 0.21
B6.PWD-Chr16 f 1779.0 540.0   10 171.0 0.303 886.0, 2732.0 1.01
B6.PWD-Chr16 m 1610.0 309.0   5 138.0 0.192 1283.0, 2074.0 -0.13
B6.PWD-Chr17 f 1336.0 288.0   8 102.0 0.216 1035.0, 1817.0 -0.98
B6.PWD-Chr17 m 1272.0 109.0   8 38.5 0.0856 1119.0, 1414.0 -1.7
B6.PWD-Chr18 f 1582.0 279.0   8 98.7 0.176 1228.0, 2098.0 0.12
B6.PWD-Chr18 m 1589.0 216.0   8 76.4 0.136 1307.0, 1971.0 -0.22
B6.PWD-Chr19 f 1821.0 293.0   8 104.0 0.161 1431.0, 2208.0 1.2
B6.PWD-Chr19 m 1918.0 675.0   8 239.0 0.352 1187.0, 3279.0 1.31
B6.PWD-Chr3 m 1754.0 517.0   9 172.0 0.295 980.0, 2473.0 0.55
B6.PWD-Chr5 f 1331.0 613.0   8 217.0 0.461 497.0, 2279.0 -1.0
B6.PWD-Chr5 m 1667.0 478.0   7 181.0 0.287 1057.0, 2191.0 0.14
B6.PWD-Chr6 f 1475.0 542.0   7 205.0 0.368 846.0, 2065.0 -0.36
B6.PWD-Chr6 m 1493.0 253.0   8 89.5 0.17 1097.0, 1830.0 -0.67
B6.PWD-Chr9 f 1054.0 383.0   4 192.0 0.363 683.0, 1590.0 -2.25
B6.PWD-Chr9 m 1240.0 361.0   7 136.0 0.291 881.0, 1844.0 -1.85
B6.PWD-ChrX.1 f 1440.0 310.0   5 138.0 0.215 1098.0, 1847.0 -0.51
B6.PWD-ChrX.1 m 1635.0 373.0   5 167.0 0.228 1122.0, 2097.0 -0.01
B6.PWD-ChrX.2 m 1411.0 191.0   9 63.5 0.135 1159.0, 1719.0 -1.05
B6.PWD-ChrX.3 f 1335.0 327.0   8 116.0 0.245 966.0, 1686.0 -0.99
B6.PWD-ChrX.3 m 1308.0 183.0   8 64.6 0.14 1065.0, 1608.0 -1.53
B6.PWD-ChrY f 1604.0 334.0   8 118.0 0.208 1261.0, 2083.0 0.22
B6.PWD-ChrY m 1740.0 261.0   8 92.2 0.15 1165.0, 2022.0 0.48
B6.PWD-mt f 1422.0 195.0   8 69.1 0.137 1150.0, 1770.0 -0.59
B6.PWD-mt m 1713.0 244.0   8 86.3 0.142 1160.0, 1973.0 0.35
C57BL/6J f 1542.0 373.0   4 186.0 0.242 1212.0, 1989.0 -0.06
C57BL/6J m 1898.0 251.0   8 88.6 0.132 1567.0, 2285.0 1.22
PWD/PhJ f 1686.0 246.0   5 110.0 0.146 1406.0, 1968.0 0.59
PWD/PhJ m 2032.0 273.0   4 136.0 0.134 1644.0, 2239.0 1.84


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6.PWD-Chr1 f 1425.0 140.1934 1700.8687 1149.1313
B6.PWD-Chr1 m 1687.1429 140.1934 1963.0116 1411.2741
B6.PWD-Chr10.1 f 2138.3333 151.4262 2436.3056 1840.3611
B6.PWD-Chr10.1 m 1835.375 131.1389 2093.4266 1577.3234
B6.PWD-Chr10.2 f 1616.9 117.2942 1847.7083 1386.0917
B6.PWD-Chr10.2 m 1500.7 117.2942 1731.5083 1269.8917
B6.PWD-Chr10.3 f 1786.8333 151.4262 2084.8056 1488.8611
B6.PWD-Chr10.3 m 1785.75 131.1389 2043.8016 1527.6984
B6.PWD-Chr11.1 f 1748.3333 107.0745 1959.0315 1537.6351
B6.PWD-Chr11.1 m 1793.8333 107.0745 2004.5315 1583.1351
B6.PWD-Chr11.2 f 1531.5556 123.639 1774.8489 1288.2622
B6.PWD-Chr11.2 m 1650.0 123.639 1893.2933 1406.7067
B6.PWD-Chr11.3 f 1522.3333 123.639 1765.6267 1279.04
B6.PWD-Chr11.3 m 1298.125 131.1389 1556.1766 1040.0734
B6.PWD-Chr12 f 1435.375 131.1389 1693.4266 1177.3234
B6.PWD-Chr12 m 1531.0 131.1389 1789.0516 1272.9484
B6.PWD-Chr14 f 1725.1429 140.1934 2001.0116 1449.2741
B6.PWD-Chr14 m 1881.125 131.1389 2139.1766 1623.0734
B6.PWD-Chr15 f 1417.875 131.1389 1675.9266 1159.8234
B6.PWD-Chr15 m 1682.25 131.1389 1940.3016 1424.1984
B6.PWD-Chr16 f 1779.0 117.2942 2009.8083 1548.1917
B6.PWD-Chr16 m 1609.6 165.8791 1936.0123 1283.1877
B6.PWD-Chr17 f 1336.0 131.1389 1594.0516 1077.9484
B6.PWD-Chr17 m 1271.5 131.1389 1529.5516 1013.4484
B6.PWD-Chr18 f 1582.25 131.1389 1840.3016 1324.1984
B6.PWD-Chr18 m 1588.625 131.1389 1846.6766 1330.5734
B6.PWD-Chr19 f 1820.875 131.1389 2078.9266 1562.8234
B6.PWD-Chr19 m 1918.25 131.1389 2176.3016 1660.1984
B6.PWD-Chr5 f 1331.0 131.1389 1589.0516 1072.9484
B6.PWD-Chr5 m 1667.1429 140.1934 1943.0116 1391.2741
B6.PWD-Chr6 f 1475.2857 140.1934 1751.1544 1199.417
B6.PWD-Chr6 m 1492.625 131.1389 1750.6766 1234.5734
B6.PWD-Chr9 f 1054.25 185.4585 1419.19 689.31
B6.PWD-Chr9 m 1239.5714 140.1934 1515.4401 963.7027
B6.PWD-ChrX.1 f 1440.2 165.8791 1766.6123 1113.7877
B6.PWD-ChrX.1 m 1634.8 165.8791 1961.2123 1308.3877
B6.PWD-ChrX.3 f 1334.75 131.1389 1592.8016 1076.6984
B6.PWD-ChrX.3 m 1307.875 131.1389 1565.9266 1049.8234
B6.PWD-ChrY f 1604.125 131.1389 1862.1766 1346.0734
B6.PWD-ChrY m 1739.5 131.1389 1997.5516 1481.4484
B6.PWD-mt f 1421.625 131.1389 1679.6766 1163.5734
B6.PWD-mt m 1713.125 131.1389 1971.1766 1455.0734
C57BL/6J f 1542.25 185.4585 1907.19 1177.31
C57BL/6J m 1897.875 131.1389 2155.9266 1639.8234
PWD/PhJ f 1686.0 165.8791 2012.4123 1359.5877
PWD/PhJ m 2032.0 185.4585 2396.94 1667.06


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6.PWD-Chr1 both 1556.0714 99.1317 1751.1401 1361.0028
B6.PWD-Chr10.1 both 1986.8542 100.159 2183.9443 1789.764
B6.PWD-Chr10.2 both 1558.8 82.9395 1722.0061 1395.5939
B6.PWD-Chr10.3 both 1786.2917 100.159 1983.3818 1589.2015
B6.PWD-Chr11.1 both 1771.0833 75.7131 1920.0695 1622.0972
B6.PWD-Chr11.2 both 1590.7778 87.426 1762.8122 1418.7434
B6.PWD-Chr11.3 both 1410.2292 90.1166 1587.5581 1232.9002
B6.PWD-Chr12 both 1483.1875 92.7292 1665.6575 1300.7175
B6.PWD-Chr14 both 1803.1339 95.9839 1992.0083 1614.2595
B6.PWD-Chr15 both 1550.0625 92.7292 1732.5325 1367.5925
B6.PWD-Chr16 both 1694.3 101.5798 1894.1859 1494.4141
B6.PWD-Chr17 both 1303.75 92.7292 1486.22 1121.28
B6.PWD-Chr18 both 1585.4375 92.7292 1767.9075 1402.9675
B6.PWD-Chr19 both 1869.5625 92.7292 2052.0325 1687.0925
B6.PWD-Chr5 both 1499.0714 95.9839 1687.9458 1310.197
B6.PWD-Chr6 both 1483.9554 95.9839 1672.8298 1295.081
B6.PWD-Chr9 both 1146.9107 116.2422 1375.649 918.1725
B6.PWD-ChrX.1 both 1537.5 117.2942 1768.3083 1306.6917
B6.PWD-ChrX.3 both 1321.3125 92.7292 1503.7825 1138.8425
B6.PWD-ChrY both 1671.8125 92.7292 1854.2825 1489.3425
B6.PWD-mt both 1567.375 92.7292 1749.845 1384.905
C57BL/6J both 1720.0625 113.5696 1943.5417 1496.5833
PWD/PhJ both 1859.0 124.4093 2103.8092 1614.1908




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA