Project measure / variable:   Paigen3   aortic_lesion

ID, description, units MPD:2836   aortic_lesion   fatty streak aortic lesion size   [µm2]  
high-fat diet study
Data set, strains Paigen3   obesity mutants   7 strains     sex: both     age: 15-19wks
Procedure histopathology
Ontology mappings

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  STRAIN COMPARISON PLOT
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Paigen3 - fatty streak aortic lesion size



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means992   µm2 2060   µm2
Median of the strain means894   µm2 1624   µm2
SD of the strain means± 811 ± 2257
Coefficient of variation (CV)0.818 1.10
Min–max range of strain means0   –   2294   µm2 0   –   6474   µm2
Mean sample size per strain8.4   mice 8.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 37033375.4753 37033375.4753 12.8945 0.0005
strain 6 253258183.3554 42209697.2259 14.6968 < 0.0001
sex:strain 6 63479627.2678 10579937.878 3.6838 0.0024
Residuals 101 290074624.5972 2872025.9861


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6(AU)-Tubtub/J f 0.0 0.0   9 0.0 0.0 -1.22
B6(AU)-Tubtub/J m 0.0 0.0   8 0.0 0.0 -0.91
B6.Cg-Ay/J f 1312.0 762.0   10 241.0 0.58 322.0, 2575.0 0.39
B6.Cg-Ay/J m 1049.0 287.0   9 95.7 0.274 649.0, 1420.0 -0.45
B6.Cg-Lepob/J f 886.0 953.0   6 389.0 1.08 -0.13
B6.Cg-Lepob/J m 1685.0 1919.0   8 678.0 1.14 -0.17
BKS.Cg-Dock7m +/+ Leprdb/J f 52.6 149.0   8 52.6 2.83 -1.16
BKS.Cg-Dock7m +/+ Leprdb/J m 158.0 473.0   9 158.0 3.0 -0.84
BKSChpLt.HRS-Cpefat/J f 2294.0 2076.0   8 734.0 0.905 1.61
BKSChpLt.HRS-Cpefat/J m 6474.0 4079.0   10 1290.0 0.63 1.96
C57BL/6J f 1505.0 867.0   9 289.0 0.576 423.0, 3335.0 0.63
C57BL/6J m 3428.0 2832.0   6 1156.0 0.826 413.0, 6787.0 0.61
C57BLKS/J f 894.0 1187.0   9 396.0 1.33 -0.12
C57BLKS/J m 1624.0 1709.0   6 698.0 1.05 131.0, 4914.0 -0.19


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J f 0.0 564.9018 1120.6131 -1120.6131
B6(AU)-Tubtub/J m 0.0 599.1688 1188.5897 -1188.5897
B6.Cg-Ay/J f 1312.4 535.9129 2375.507 249.293
B6.Cg-Ay/J m 1049.4444 564.9018 2170.0576 -71.1687
B6.Cg-Lepob/J f 886.1667 691.8605 2258.6319 -486.2985
B6.Cg-Lepob/J m 1684.75 599.1688 2873.3397 496.1603
BKS.Cg-Dock7m +/+ Leprdb/J f 52.625 599.1688 1241.2147 -1135.9647
BKS.Cg-Dock7m +/+ Leprdb/J m 157.6667 564.9018 1278.2798 -962.9465
BKSChpLt.HRS-Cpefat/J f 2293.75 599.1688 3482.3397 1105.1603
BKSChpLt.HRS-Cpefat/J m 6473.7 535.9129 7536.807 5410.593
C57BL/6J f 1505.0 564.9018 2625.6131 384.3869
C57BL/6J m 3427.8333 691.8605 4800.2985 2055.3681
C57BLKS/J f 894.0 564.9018 2014.6131 -226.6131
C57BLKS/J m 1624.3333 691.8605 2996.7985 251.8681


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J both 0.0 411.7394 816.7802 -816.7802
B6.Cg-Ay/J both 1180.9222 389.3317 1953.2515 408.5929
B6.Cg-Lepob/J both 1285.4583 457.6227 2193.2587 377.6579
BKS.Cg-Dock7m +/+ Leprdb/J both 105.1458 411.7394 921.926 -711.6343
BKSChpLt.HRS-Cpefat/J both 4383.725 401.9346 5181.0552 3586.3948
C57BL/6J both 2466.4167 446.5941 3352.3391 1580.4942
C57BLKS/J both 1259.1667 446.5941 2145.0891 373.2442




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA