MPD: Project measure / variable: Lake2 hindlimb

Project measure / variable: Lake2 hindlimb_dorsal

ID, description, units	MPD:21743 hindlimb_dorsal hindlimb splay evaluation via dorso-ventral view in arena (score 0-2) [score]
Data set, strains	Lake2 B6.A consomic w/par 23 strains sex: both age: 8wks
Procedure	observation (SHIRPA)
Ontology mappings	MA:0000026 hindlimb MP:0004263 abnormal limb posture VT:0000016 hindlimb conformation trait

STRAIN COMPARISON PLOT

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Visualization Options Least squares means Alphabetical order Strains on X-axis Individual points

Lake2 - hindlimb splay evaluation via dorso-ventral view in arena (score 0-2)

MEASURE SUMMARY

Measure Summary	Female	Male
Number of strains tested	23 strains	23 strains
Mean of the strain means	0.0467 score	0.0109 score
Median of the strain means	0 score	0 score
SD of the strain means	± 0.120	± 0.0360
Coefficient of variation (CV)	2.57	3.31
Min–max range of strain means	0 – 0.500 score	0 – 0.125 score
Mean sample size per strain	8.1 mice	7.8 mice

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p value (Pr>F)
sex	1	0.3496	0.3496	10.6286	0.0012
strain	22	2.9014	0.1319	4.0097	< 0.0001
sex:strain	22	1.5246	0.0693	2.107	0.003
Residuals	320	10.525	0.0329

Q-Q normality assessment based on residuals

STRAIN MEANS (UNADJUSTED)

Strain	Sex	Mean	SD	N mice	SEM	CV	Z score
A/J	f	0.2	0.414	15	0.107	2.07	1.28
A/J	m	0.0	0.0	8	0.0	0.0	-0.3
B6.A-Chr1	f	0.0	0.0	4	0.0	0.0	-0.39
B6.A-Chr1	m	0.0	0.0	8	0.0	0.0	-0.3
B6.A-Chr10	f	0.0	0.0	8	0.0	0.0	-0.39
B6.A-Chr10	m	0.0	0.0	8	0.0	0.0	-0.3
B6.A-Chr11	f	0.0	0.0	8	0.0	0.0	-0.39
B6.A-Chr11	m	0.0	0.0	10	0.0	0.0	-0.3
B6.A-Chr12	f	0.0	0.0	8	0.0	0.0	-0.39
B6.A-Chr12	m	0.0	0.0	8	0.0	0.0	-0.3
B6.A-Chr13	f	0.0	0.0	5	0.0	0.0	-0.39
B6.A-Chr13	m	0.0	0.0	7	0.0	0.0	-0.3
B6.A-Chr14	f	0.0	0.0	8	0.0	0.0	-0.39
B6.A-Chr14	m	0.0	0.0	8	0.0	0.0	-0.3
B6.A-Chr15	f	0.0	0.0	8	0.0	0.0	-0.39
B6.A-Chr15	m	0.0	0.0	8	0.0	0.0	-0.3
B6.A-Chr16	f	0.25	0.463	8	0.164	1.85	1.69
B6.A-Chr16	m	0.125	0.354	8	0.125	2.83	3.17
B6.A-Chr17	f	0.0	0.0	8	0.0	0.0	-0.39
B6.A-Chr17	m	0.0	0.0	8	0.0	0.0	-0.3
B6.A-Chr18	f	0.0	0.0	8	0.0	0.0	-0.39
B6.A-Chr18	m	0.0	0.0	8	0.0	0.0	-0.3
B6.A-Chr19	f	0.0	0.0	8	0.0	0.0	-0.39
B6.A-Chr19	m	0.0	0.0	8	0.0	0.0	-0.3
B6.A-Chr2	f	0.125	0.354	8	0.125	2.83	0.65
B6.A-Chr2	m	0.0	0.0	4	0.0	0.0	-0.3
B6.A-Chr3	f	0.0	0.0	8	0.0	0.0	-0.39
B6.A-Chr3	m	0.0	0.0	8	0.0	0.0	-0.3
B6.A-Chr4	f	0.0	0.0	8	0.0	0.0	-0.39
B6.A-Chr4	m	0.125	0.354	8	0.125	2.83	3.17
B6.A-Chr5	f	0.0	0.0	8	0.0	0.0	-0.39
B6.A-Chr5	m	0.0	0.0	8	0.0	0.0	-0.3
B6.A-Chr6	f	0.0	0.0	8	0.0	0.0	-0.39
B6.A-Chr6	m	0.0	0.0	8	0.0	0.0	-0.3
B6.A-Chr7	f	0.0	0.0	8	0.0	0.0	-0.39
B6.A-Chr7	m	0.0	0.0	8	0.0	0.0	-0.3
B6.A-Chr8	f	0.0	0.0	8	0.0	0.0	-0.39
B6.A-Chr8	m	0.0	0.0	8	0.0	0.0	-0.3
B6.A-Chr9	f	0.0	0.0	7	0.0	0.0	-0.39
B6.A-Chr9	m	0.0	0.0	2	0.0	0.0	-0.3
B6.A-ChrX	f	0.0	0.0	8	0.0	0.0	-0.39
B6.A-ChrX	m	0.0	0.0	8	0.0	0.0	-0.3
B6.A-ChrY	f	0.0	0.0	8	0.0	0.0	-0.39
B6.A-ChrY	m	0.0	0.0	8	0.0	0.0	-0.3
C57BL/6J	f	0.5	0.516	16	0.129	1.03	3.77
C57BL/6J	m	0.0	0.0	8	0.0	0.0	-0.3

LEAST SQUARES MEANS (MODEL-ADJUSTED)

Strain	Sex	Mean	SEM	UpperCL	LowerCL
A/J	f	0.2	0.0468	0.2921	0.1079
A/J	m	0.0	0.0641	0.1261	-0.1261
B6.A-Chr1	f	0.0	0.0907	0.1784	-0.1784
B6.A-Chr1	m	0.0	0.0641	0.1261	-0.1261
B6.A-Chr10	f	0.0	0.0641	0.1261	-0.1261
B6.A-Chr10	m	0.0	0.0641	0.1261	-0.1261
B6.A-Chr11	f	0.0	0.0641	0.1261	-0.1261
B6.A-Chr11	m	0.0	0.0574	0.1128	-0.1128
B6.A-Chr12	f	0.0	0.0641	0.1261	-0.1261
B6.A-Chr12	m	0.0	0.0641	0.1261	-0.1261
B6.A-Chr13	f	0.0	0.0811	0.1596	-0.1596
B6.A-Chr13	m	0.0	0.0685	0.1349	-0.1349
B6.A-Chr14	f	0.0	0.0641	0.1261	-0.1261
B6.A-Chr14	m	0.0	0.0641	0.1261	-0.1261
B6.A-Chr15	f	0.0	0.0641	0.1261	-0.1261
B6.A-Chr15	m	0.0	0.0641	0.1261	-0.1261
B6.A-Chr16	f	0.25	0.0641	0.3761	0.1239
B6.A-Chr16	m	0.125	0.0641	0.2511	-0.0011
B6.A-Chr17	f	0.0	0.0641	0.1261	-0.1261
B6.A-Chr17	m	0.0	0.0641	0.1261	-0.1261
B6.A-Chr18	f	0.0	0.0641	0.1261	-0.1261
B6.A-Chr18	m	0.0	0.0641	0.1261	-0.1261
B6.A-Chr19	f	0.0	0.0641	0.1261	-0.1261
B6.A-Chr19	m	0.0	0.0641	0.1261	-0.1261
B6.A-Chr2	f	0.125	0.0641	0.2511	-0.0011
B6.A-Chr2	m	0.0	0.0907	0.1784	-0.1784
B6.A-Chr3	f	0.0	0.0641	0.1261	-0.1261
B6.A-Chr3	m	0.0	0.0641	0.1261	-0.1261
B6.A-Chr4	f	0.0	0.0641	0.1261	-0.1261
B6.A-Chr4	m	0.125	0.0641	0.2511	-0.0011
B6.A-Chr5	f	0.0	0.0641	0.1261	-0.1261
B6.A-Chr5	m	0.0	0.0641	0.1261	-0.1261
B6.A-Chr6	f	0.0	0.0641	0.1261	-0.1261
B6.A-Chr6	m	0.0	0.0641	0.1261	-0.1261
B6.A-Chr7	f	0.0	0.0641	0.1261	-0.1261
B6.A-Chr7	m	0.0	0.0641	0.1261	-0.1261
B6.A-Chr8	f	0.0	0.0641	0.1261	-0.1261
B6.A-Chr8	m	0.0	0.0641	0.1261	-0.1261
B6.A-Chr9	f	0.0	0.0685	0.1349	-0.1349
B6.A-Chr9	m	0.0	0.1282	0.2523	-0.2523
B6.A-ChrX	f	0.0	0.0641	0.1261	-0.1261
B6.A-ChrX	m	0.0	0.0641	0.1261	-0.1261
B6.A-ChrY	f	0.0	0.0641	0.1261	-0.1261
B6.A-ChrY	m	0.0	0.0641	0.1261	-0.1261
C57BL/6J	f	0.5	0.0453	0.5892	0.4108
C57BL/6J	m	0.0	0.0641	0.1261	-0.1261

LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED

Strain	Sex	Mean	SEM	UpperCL	LowerCL
A/J	both	0.1	0.0397	0.1781	0.0219
B6.A-Chr1	both	0.0	0.0555	0.1092	-0.1092
B6.A-Chr10	both	0.0	0.0453	0.0892	-0.0892
B6.A-Chr11	both	0.0	0.043	0.0846	-0.0846
B6.A-Chr12	both	0.0	0.0453	0.0892	-0.0892
B6.A-Chr13	both	0.0	0.0531	0.1045	-0.1045
B6.A-Chr14	both	0.0	0.0453	0.0892	-0.0892
B6.A-Chr15	both	0.0	0.0453	0.0892	-0.0892
B6.A-Chr16	both	0.1875	0.0453	0.2767	0.0983
B6.A-Chr17	both	0.0	0.0453	0.0892	-0.0892
B6.A-Chr18	both	0.0	0.0453	0.0892	-0.0892
B6.A-Chr19	both	0.0	0.0453	0.0892	-0.0892
B6.A-Chr2	both	0.0625	0.0555	0.1717	-0.0467
B6.A-Chr3	both	0.0	0.0453	0.0892	-0.0892
B6.A-Chr4	both	0.0625	0.0453	0.1517	-0.0267
B6.A-Chr5	both	0.0	0.0453	0.0892	-0.0892
B6.A-Chr6	both	0.0	0.0453	0.0892	-0.0892
B6.A-Chr7	both	0.0	0.0453	0.0892	-0.0892
B6.A-Chr8	both	0.0	0.0453	0.0892	-0.0892
B6.A-Chr9	both	0.0	0.0727	0.143	-0.143
B6.A-ChrX	both	0.0	0.0453	0.0892	-0.0892
B6.A-ChrY	both	0.0	0.0453	0.0892	-0.0892
C57BL/6J	both	0.25	0.0393	0.3273	0.1727

INDIVIDUAL ANIMAL VALUES

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GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA