Project measure / variable:   Donahue1   IGF_1

ID, description, units MPD:11532   IGF_1   insulin-like growth factor 1 (adjusted serum IGF-1)   [ng/mL]  
Data set, strains Donahue1   inbred w/CC7   30 strains     sex: both     age: 15-16wks
Procedure hormone quantification
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  STRAIN COMPARISON PLOT
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Donahue1 - insulin-like growth factor 1 (adjusted serum IGF-1)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested30 strains30 strains
Mean of the strain means107   ng/mL 107   ng/mL
Median of the strain means108   ng/mL 108   ng/mL
SD of the strain means± 21.9 ± 19.3
Coefficient of variation (CV)0.204 0.181
Min–max range of strain means54.3   –   163   ng/mL 60.5   –   138   ng/mL
Mean sample size per strain9.6   mice 8.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 81.55 81.55 0.4857 0.4862
strain 29 211208.2662 7283.0437 43.3792 < 0.0001
sex:strain 29 20535.9172 708.1351 4.2178 < 0.0001
Residuals 493 82770.9448 167.8924


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 91.2 8.88   10 2.81 0.0974 78.8, 104.0 -0.73
129S1/SvImJ m 109.0 8.71   9 2.9 0.0797 95.1, 120.0 0.1
129X1/SvJ f 109.0 13.8   9 4.59 0.126 94.2, 142.0 0.08
129X1/SvJ m 135.0 9.14   4 4.57 0.0678 127.0, 148.0 1.45
A/J f 106.0 17.6   10 5.58 0.166 83.1, 130.0 -0.05
A/J m 103.0 11.1   10 3.5 0.107 84.3, 120.0 -0.21
AKR/J f 115.0 13.0   10 4.1 0.113 96.2, 136.0 0.36
AKR/J m 104.0 8.14   4 4.07 0.0783 96.5, 114.0 -0.15
BALB/cJ f 107.0 9.23   10 2.92 0.086 97.6, 129.0 -0.01
BALB/cJ m 118.0 11.2   10 3.54 0.0946 100.0, 132.0 0.57
BTBR T+ Itpr3tf/J f 163.0 11.3   9 3.75 0.0691 148.0, 182.0 2.55
BTBR T+ Itpr3tf/J m 136.0 10.5   10 3.33 0.0776 120.0, 152.0 1.5
BUB/BnJ f 109.0 10.1   10 3.19 0.0929 84.9, 122.0 0.08
BUB/BnJ m 108.0 16.0   6 6.53 0.148 90.3, 134.0 0.05
C3H/HeJ f 127.0 17.4   10 5.49 0.136 97.2, 153.0 0.9
C3H/HeJ m 123.0 9.77   10 3.09 0.0796 110.0, 136.0 0.83
C57BL/6J f 83.5 6.55   10 2.07 0.0784 74.2, 94.9 -1.08
C57BL/6J m 87.4 3.84   10 1.21 0.044 80.1, 93.4 -1.01
C57L/J f 113.0 10.4   10 3.28 0.0914 95.9, 132.0 0.26
C57L/J m 94.7 15.9   8 5.63 0.168 57.3, 106.0 -0.64
C58/J f 111.0 10.4   10 3.28 0.0935 97.0, 134.0 0.17
C58/J m 83.1 4.6   9 1.53 0.0554 77.8, 90.4 -1.24
CAST/EiJ f 120.0 13.7   10 4.33 0.114 95.9, 142.0 0.58
CAST/EiJ m 138.0 13.6   8 4.81 0.0987 108.0, 153.0 1.6
CZECHII/EiJ f 80.2 13.8   8 4.87 0.172 60.2, 105.0 -1.23
CZECHII/EiJ m 88.5 4.39   9 1.46 0.0496 80.1, 95.2 -0.96
DBA/2J f 82.8 11.9   10 3.76 0.143 63.1, 100.0 -1.11
DBA/2J m 88.4 10.5   10 3.33 0.119 75.1, 107.0 -0.96
FVB/NJ f 85.8 6.88   10 2.18 0.0803 75.3, 95.9 -0.98
FVB/NJ m 95.1 9.4   10 2.97 0.0988 82.1, 108.0 -0.62
JF1/MsJ f 131.0 12.5   9 4.18 0.0956 114.0, 145.0 1.09
JF1/MsJ m 120.0 10.0   10 3.17 0.0837 106.0, 135.0 0.67
MOLF/EiJ f 101.0 9.11   10 2.88 0.0898 86.4, 118.0 -0.28
MOLF/EiJ m 93.3 18.8   8 6.65 0.202 58.6, 112.0 -0.71
MSM/MsJ f 95.5 21.5   8 7.59 0.225 51.1, 127.0 -0.53
MSM/MsJ m 110.0 11.9   7 4.48 0.108 94.1, 129.0 0.16
NOD/ShiLtJ f 127.0 14.5   10 4.58 0.114 110.0, 154.0 0.9
NOD/ShiLtJ m 133.0 20.0   9 6.67 0.151 103.0, 160.0 1.35
NZB/BlNJ f 110.0 13.0   10 4.1 0.118 94.8, 142.0 0.13
NZB/BlNJ m 107.0 18.2   10 5.77 0.17 80.7, 131.0 0.0
NZW/LacJ f 105.0 11.4   10 3.59 0.108 87.1, 124.0 -0.1
NZW/LacJ m 115.0 7.05   10 2.23 0.0614 106.0, 128.0 0.41
PERA/EiJ f 134.0 10.9   8 3.85 0.0815 119.0, 154.0 1.22
PERA/EiJ m 119.0 18.8   9 6.26 0.158 94.5, 139.0 0.62
PL/J f 98.3 12.6   10 3.99 0.128 81.6, 113.0 -0.41
PL/J m 92.8 19.7   7 7.43 0.212 50.5, 111.0 -0.73
PWK/PhJ f 121.0 10.8   7 4.08 0.0896 106.0, 137.0 0.63
PWK/PhJ m 123.0 23.7   9 7.91 0.193 84.4, 160.0 0.83
SEA/GnJ f 141.0 12.2   14 3.27 0.0864 122.0, 162.0 1.54
SEA/GnJ m 132.0 12.5   9 4.16 0.0949 115.0, 152.0 1.29
SJL/J f 81.5 11.5   10 3.65 0.142 64.6, 102.0 -1.17
SJL/J m 88.5 12.1   10 3.83 0.137 65.2, 107.0 -0.96
SM/J f 54.3 11.4   10 3.59 0.209 29.9, 64.6 -2.42
SM/J m 60.5 23.5   10 7.44 0.389 14.3, 80.2 -2.41
SPRET/EiJ f 123.0 16.7   9 5.57 0.136 100.0, 142.0 0.72
SPRET/EiJ m 126.0 15.5   10 4.91 0.123 103.0, 154.0 0.98
SWR/J f 106.0 9.07   10 2.87 0.0858 86.4, 116.0 -0.05
SWR/J m 94.9 8.04   9 2.68 0.0846 83.0, 103.0 -0.63
WSB/EiJ f 84.0 9.52   10 3.01 0.113 65.1, 94.7 -1.06
WSB/EiJ m 83.4 7.89   8 2.79 0.0945 71.1, 92.3 -1.22


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 91.19 4.0975 99.2407 83.1393
129S1/SvImJ m 109.2333 4.3191 117.7195 100.7472
129X1/SvJ f 109.1889 4.3191 117.675 100.7028
129X1/SvJ m 134.75 6.4787 147.4792 122.0208
A/J f 106.38 4.0975 114.4307 98.3293
A/J m 103.3 4.0975 111.3507 95.2493
AKR/J f 114.72 4.0975 122.7707 106.6693
AKR/J m 103.925 6.4787 116.6542 91.1958
BALB/cJ f 107.29 4.0975 115.3407 99.2393
BALB/cJ m 118.2 4.0975 126.2507 110.1493
BTBR T+ Itpr3tf/J f 162.8889 4.3191 171.375 154.4028
BTBR T+ Itpr3tf/J m 135.7 4.0975 143.7507 127.6493
BUB/BnJ f 108.79 4.0975 116.8407 100.7393
BUB/BnJ m 108.3833 5.2898 118.7767 97.99
C3H/HeJ f 127.32 4.0975 135.3707 119.2693
C3H/HeJ m 122.8 4.0975 130.8507 114.7493
C57BL/6J f 83.45 4.0975 91.5007 75.3993
C57BL/6J m 87.38 4.0975 95.4307 79.3293
C57L/J f 113.39 4.0975 121.4407 105.3393
C57L/J m 94.7125 4.5811 103.7134 85.7116
C58/J f 111.0 4.0975 119.0507 102.9493
C58/J m 83.0889 4.3191 91.575 74.6028
CAST/EiJ f 119.79 4.0975 127.8407 111.7393
CAST/EiJ m 138.0 4.5811 147.0009 128.9991
CZECHII/EiJ f 80.1875 4.5811 89.1884 71.1866
CZECHII/EiJ m 88.4667 4.3191 96.9528 79.9805
DBA/2J f 82.84 4.0975 90.8907 74.7893
DBA/2J m 88.41 4.0975 96.4607 80.3593
FVB/NJ f 85.75 4.0975 93.8007 77.6993
FVB/NJ m 95.11 4.0975 103.1607 87.0593
JF1/MsJ f 131.2222 4.3191 139.7084 122.7361
JF1/MsJ m 119.6 4.0975 127.6507 111.5493
MOLF/EiJ f 101.4 4.0975 109.4507 93.3493
MOLF/EiJ m 93.325 4.5811 102.3259 84.3241
MSM/MsJ f 95.55 4.5811 104.5509 86.5491
MSM/MsJ m 110.0143 4.8974 119.6367 100.3919
NOD/ShiLtJ f 126.7 4.0975 134.7507 118.6493
NOD/ShiLtJ m 132.6667 4.3191 141.1528 124.1805
NZB/BlNJ f 110.08 4.0975 118.1307 102.0293
NZB/BlNJ m 107.2 4.0975 115.2507 99.1493
NZW/LacJ f 105.21 4.0975 113.2607 97.1593
NZW/LacJ m 114.8 4.0975 122.8507 106.7493
PERA/EiJ f 133.5 4.5811 142.5009 124.4991
PERA/EiJ m 119.1 4.3191 127.5861 110.6139
PL/J f 98.29 4.0975 106.3407 90.2393
PL/J m 92.8143 4.8974 102.4367 83.1919
PWK/PhJ f 120.5714 4.8974 130.1938 110.9491
PWK/PhJ m 122.6889 4.3191 131.175 114.2028
SEA/GnJ f 141.4286 3.463 148.2326 134.6245
SEA/GnJ m 131.6667 4.3191 140.1528 123.1805
SJL/J f 81.53 4.0975 89.5807 73.4793
SJL/J m 88.5 4.0975 96.5507 80.4493
SM/J f 54.32 4.0975 62.3707 46.2693
SM/J m 60.54 4.0975 68.5907 52.4893
SPRET/EiJ f 123.2222 4.3191 131.7084 114.7361
SPRET/EiJ m 126.3 4.0975 134.3507 118.2493
SWR/J f 105.82 4.0975 113.8707 97.7693
SWR/J m 94.9333 4.3191 103.4195 86.4472
WSB/EiJ f 84.01 4.0975 92.0607 75.9593
WSB/EiJ m 83.4375 4.5811 92.4384 74.4366


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 100.2117 2.9767 106.0603 94.363
129X1/SvJ both 121.9694 3.8932 129.6187 114.3201
A/J both 104.84 2.8973 110.5327 99.1473
AKR/J both 109.3225 3.8328 116.8532 101.7918
BALB/cJ both 112.745 2.8973 118.4377 107.0523
BTBR T+ Itpr3tf/J both 149.2944 2.9767 155.1431 143.4458
BUB/BnJ both 108.5867 3.3456 115.16 102.0133
C3H/HeJ both 125.06 2.8973 130.7527 119.3673
C57BL/6J both 85.415 2.8973 91.1077 79.7223
C57L/J both 104.0512 3.0731 110.0892 98.0133
C58/J both 97.0444 2.9767 102.8931 91.1958
CAST/EiJ both 128.895 3.0731 134.933 122.857
CZECHII/EiJ both 84.3271 3.1481 90.5124 78.1418
DBA/2J both 85.625 2.8973 91.3177 79.9323
FVB/NJ both 90.43 2.8973 96.1227 84.7373
JF1/MsJ both 125.4111 2.9767 131.2598 119.5624
MOLF/EiJ both 97.3625 3.0731 103.4005 91.3245
MSM/MsJ both 102.7821 3.353 109.3701 96.1942
NOD/ShiLtJ both 129.6833 2.9767 135.532 123.8347
NZB/BlNJ both 108.64 2.8973 114.3327 102.9473
NZW/LacJ both 110.005 2.8973 115.6977 104.3123
PERA/EiJ both 126.3 3.1481 132.4853 120.1147
PL/J both 95.5521 3.1927 101.8252 89.2791
PWK/PhJ both 121.6302 3.2649 128.0451 115.2152
SEA/GnJ both 136.5476 2.768 141.9861 131.1091
SJL/J both 85.015 2.8973 90.7077 79.3223
SM/J both 57.43 2.8973 63.1227 51.7373
SPRET/EiJ both 124.7611 2.9767 130.6098 118.9124
SWR/J both 100.3767 2.9767 106.2253 94.528
WSB/EiJ both 83.7237 3.0731 89.7617 77.6858




  GWAS USING LINEAR MIXED MODELS