Project measure / variable:   Donahue1   osteocalcin

ID, description, units MPD:11530   osteocalcin   osteocalcin (serum OC)   [ng/mL]  
Data set, strains Donahue1   inbred w/CC7   30 strains     sex: both     age: 15-16wks
Procedure hormone quantification
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  STRAIN COMPARISON PLOT
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Donahue1 - osteocalcin (serum OC)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested30 strains30 strains
Mean of the strain means56.7   ng/mL 46.0   ng/mL
Median of the strain means53.2   ng/mL 44.0   ng/mL
SD of the strain means± 15.8 ± 12.4
Coefficient of variation (CV)0.280 0.270
Min–max range of strain means35.0   –   91.1   ng/mL 26.0   –   82.9   ng/mL
Mean sample size per strain9.6   mice 8.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 16056.7963 16056.7963 70.0814 < 0.0001
strain 29 74457.0181 2567.4834 11.206 < 0.0001
sex:strain 29 37203.7066 1282.8864 5.5993 < 0.0001
Residuals 488 111808.7563 229.1163


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 84.0 18.2   10 5.74 0.216 58.0, 120.0 1.73
129S1/SvImJ m 82.9 32.9   9 11.0 0.397 32.0, 129.0 2.98
129X1/SvJ f 59.0 19.1   9 6.38 0.324 33.0, 99.0 0.15
129X1/SvJ m 26.0 6.58   4 3.29 0.253 19.0, 33.0 -1.61
A/J f 47.7 5.54   10 1.75 0.116 42.0, 57.0 -0.57
A/J m 46.6 8.47   10 2.68 0.182 34.0, 58.0 0.05
AKR/J f 40.3 10.9   10 3.44 0.27 23.0, 64.0 -1.03
AKR/J m 52.5 11.9   4 5.95 0.227 39.0, 63.0 0.53
BALB/cJ f 51.0 9.09   10 2.88 0.178 36.0, 63.0 -0.36
BALB/cJ m 27.8 6.07   10 1.92 0.218 21.0, 37.0 -1.46
BTBR T+ Itpr3tf/J f 73.8 8.04   9 2.68 0.109 62.0, 84.0 1.08
BTBR T+ Itpr3tf/J m 49.4 12.4   10 3.92 0.251 36.0, 70.0 0.28
BUB/BnJ f 40.6 8.44   10 2.67 0.208 33.0, 62.0 -1.01
BUB/BnJ m 33.3 17.0   6 6.94 0.51 22.0, 66.0 -1.02
C3H/HeJ f 58.0 7.24   10 2.29 0.125 49.0, 69.0 0.08
C3H/HeJ m 55.5 24.9   10 7.87 0.449 23.0, 113.0 0.77
C57BL/6J f 59.4 9.58   10 3.03 0.161 50.0, 75.0 0.17
C57BL/6J m 60.3 10.6   10 3.35 0.176 42.0, 75.0 1.16
C57L/J f 42.1 5.8   10 1.83 0.138 36.0, 53.0 -0.92
C57L/J m 40.1 20.4   7 7.69 0.507 14.0, 65.0 -0.47
C58/J f 70.6 14.9   10 4.71 0.211 48.0, 86.0 0.88
C58/J m 28.8 8.23   9 2.74 0.286 20.0, 43.0 -1.38
CAST/EiJ f 57.3 17.8   10 5.64 0.311 35.0, 81.0 0.04
CAST/EiJ m 61.1 15.4   8 5.46 0.252 40.0, 90.0 1.22
CZECHII/EiJ f 69.1 18.8   8 6.66 0.272 42.0, 98.0 0.79
CZECHII/EiJ m 39.7 10.7   9 3.57 0.27 24.0, 57.0 -0.5
DBA/2J f 54.4 8.68   10 2.75 0.16 43.0, 68.0 -0.14
DBA/2J m 50.9 16.2   10 5.13 0.319 33.0, 81.0 0.4
FVB/NJ f 41.7 6.85   10 2.17 0.164 30.0, 51.0 -0.94
FVB/NJ m 32.6 10.1   10 3.2 0.31 20.0, 49.0 -1.08
JF1/MsJ f 40.6 7.83   9 2.61 0.193 28.0, 55.0 -1.01
JF1/MsJ m 30.6 5.19   10 1.64 0.17 18.0, 36.0 -1.24
MOLF/EiJ f 86.7 11.3   10 3.58 0.131 73.0, 105.0 1.9
MOLF/EiJ m 43.1 14.5   8 5.14 0.337 27.0, 63.0 -0.23
MSM/MsJ f 49.6 15.1   8 5.33 0.304 22.0, 70.0 -0.45
MSM/MsJ m 54.1 13.2   7 4.98 0.243 39.0, 73.0 0.66
NOD/ShiLtJ f 41.2 14.1   10 4.45 0.342 22.0, 63.0 -0.98
NOD/ShiLtJ m 45.9 16.2   8 5.71 0.352 23.0, 72.0 -0.01
NZB/BlNJ f 75.4 12.0   10 3.78 0.159 57.0, 94.0 1.18
NZB/BlNJ m 42.9 16.6   10 5.26 0.388 17.0, 80.0 -0.25
NZW/LacJ f 58.1 10.1   10 3.2 0.174 44.0, 80.0 0.09
NZW/LacJ m 42.1 8.43   10 2.66 0.2 33.0, 59.0 -0.31
PERA/EiJ f 49.6 13.0   8 4.61 0.263 30.0, 65.0 -0.45
PERA/EiJ m 44.8 20.1   9 6.7 0.449 23.0, 83.0 -0.09
PL/J f 52.0 15.9   10 5.02 0.305 31.0, 78.0 -0.29
PL/J m 53.2 8.13   6 3.32 0.153 41.0, 62.0 0.58
PWK/PhJ f 83.0 18.5   7 7.01 0.223 64.0, 120.0 1.66
PWK/PhJ m 67.3 39.3   9 13.1 0.583 7.0, 146.0 1.72
SEA/GnJ f 91.1 27.6   14 7.39 0.303 41.0, 149.0 2.17
SEA/GnJ m 40.6 8.26   9 2.75 0.204 24.0, 51.0 -0.43
SJL/J f 49.4 10.1   10 3.21 0.205 33.0, 64.0 -0.46
SJL/J m 54.3 14.3   10 4.53 0.264 39.0, 79.0 0.67
SM/J f 45.6 14.2   10 4.48 0.311 33.0, 70.0 -0.7
SM/J m 50.8 21.5   9 7.17 0.424 30.0, 103.0 0.39
SPRET/EiJ f 35.0 8.47   9 2.82 0.242 22.0, 46.0 -1.37
SPRET/EiJ m 39.4 5.64   10 1.78 0.143 29.0, 50.0 -0.53
SWR/J f 36.7 8.92   9 2.97 0.243 22.0, 45.0 -1.26
SWR/J m 39.8 25.1   9 8.36 0.631 20.0, 100.0 -0.5
WSB/EiJ f 56.7 10.2   10 3.23 0.18 40.0, 68.0 0.0
WSB/EiJ m 42.5 14.7   8 5.19 0.346 28.0, 73.0 -0.28


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 84.0 4.7866 93.4049 74.5951
129S1/SvImJ m 82.8889 5.0455 92.8025 72.9752
129X1/SvJ f 59.0 5.0455 68.9136 49.0864
129X1/SvJ m 26.0 7.5683 40.8705 11.1295
A/J f 47.7 4.7866 57.1049 38.2951
A/J m 46.6 4.7866 56.0049 37.1951
AKR/J f 40.3 4.7866 49.7049 30.8951
AKR/J m 52.5 7.5683 67.3705 37.6295
BALB/cJ f 51.0 4.7866 60.4049 41.5951
BALB/cJ m 27.8 4.7866 37.2049 18.3951
BTBR T+ Itpr3tf/J f 73.7778 5.0455 83.6914 63.8641
BTBR T+ Itpr3tf/J m 49.4 4.7866 58.8049 39.9951
BUB/BnJ f 40.6 4.7866 50.0049 31.1951
BUB/BnJ m 33.3333 6.1795 45.475 21.1916
C3H/HeJ f 58.0 4.7866 67.4049 48.5951
C3H/HeJ m 55.5 4.7866 64.9049 46.0951
C57BL/6J f 59.4 4.7866 68.8049 49.9951
C57BL/6J m 60.3 4.7866 69.7049 50.8951
C57L/J f 42.1 4.7866 51.5049 32.6951
C57L/J m 40.1429 5.7211 51.3839 28.9018
C58/J f 70.6 4.7866 80.0049 61.1951
C58/J m 28.7778 5.0455 38.6914 18.8641
CAST/EiJ f 57.3 4.7866 66.7049 47.8951
CAST/EiJ m 61.125 5.3516 71.64 50.61
CZECHII/EiJ f 69.125 5.3516 79.64 58.61
CZECHII/EiJ m 39.6667 5.0455 49.5803 29.753
DBA/2J f 54.4 4.7866 63.8049 44.9951
DBA/2J m 50.9 4.7866 60.3049 41.4951
FVB/NJ f 41.7 4.7866 51.1049 32.2951
FVB/NJ m 32.6 4.7866 42.0049 23.1951
JF1/MsJ f 40.5556 5.0455 50.4692 30.6419
JF1/MsJ m 30.6 4.7866 40.0049 21.1951
MOLF/EiJ f 86.7 4.7866 96.1049 77.2951
MOLF/EiJ m 43.125 5.3516 53.64 32.61
MSM/MsJ f 49.625 5.3516 60.14 39.11
MSM/MsJ m 54.1429 5.7211 65.3839 42.9018
NOD/ShiLtJ f 41.2 4.7866 50.6049 31.7951
NOD/ShiLtJ m 45.875 5.3516 56.39 35.36
NZB/BlNJ f 75.4 4.7866 84.8049 65.9951
NZB/BlNJ m 42.9 4.7866 52.3049 33.4951
NZW/LacJ f 58.1 4.7866 67.5049 48.6951
NZW/LacJ m 42.1 4.7866 51.5049 32.6951
PERA/EiJ f 49.625 5.3516 60.14 39.11
PERA/EiJ m 44.7778 5.0455 54.6914 34.8641
PL/J f 52.0 4.7866 61.4049 42.5951
PL/J m 53.1667 6.1795 65.3084 41.025
PWK/PhJ f 83.0 5.7211 94.241 71.759
PWK/PhJ m 67.3333 5.0455 77.247 57.4197
SEA/GnJ f 91.1429 4.0454 99.0915 83.1943
SEA/GnJ m 40.5556 5.0455 50.4692 30.6419
SJL/J f 49.4 4.7866 58.8049 39.9951
SJL/J m 54.3 4.7866 63.7049 44.8951
SM/J f 45.6 4.7866 55.0049 36.1951
SM/J m 50.7778 5.0455 60.6914 40.8641
SPRET/EiJ f 35.0 5.0455 44.9136 25.0864
SPRET/EiJ m 39.4 4.7866 48.8049 29.9951
SWR/J f 36.6667 5.0455 46.5803 26.753
SWR/J m 39.7778 5.0455 49.6914 29.8641
WSB/EiJ f 56.7 4.7866 66.1049 47.2951
WSB/EiJ m 42.5 5.3516 53.015 31.985


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 83.4444 3.4774 90.277 76.6119
129X1/SvJ both 42.5 4.548 51.436 33.564
A/J both 47.15 3.3846 53.8003 40.4997
AKR/J both 46.4 4.4775 55.1975 37.6025
BALB/cJ both 39.4 3.3846 46.0503 32.7497
BTBR T+ Itpr3tf/J both 61.5889 3.4774 68.4214 54.7564
BUB/BnJ both 36.9667 3.9083 44.6457 29.2876
C3H/HeJ both 56.75 3.3846 63.4003 50.0997
C57BL/6J both 59.85 3.3846 66.5003 53.1997
C57L/J both 41.1214 3.7297 48.4497 33.7932
C58/J both 49.6889 3.4774 56.5214 42.8564
CAST/EiJ both 59.2125 3.59 66.2662 52.1588
CZECHII/EiJ both 54.3958 3.6775 61.6216 47.1701
DBA/2J both 52.65 3.3846 59.3003 45.9997
FVB/NJ both 37.15 3.3846 43.8003 30.4997
JF1/MsJ both 35.5778 3.4774 42.4103 28.7453
MOLF/EiJ both 64.9125 3.59 71.9662 57.8588
MSM/MsJ both 51.8839 3.917 59.5801 44.1877
NOD/ShiLtJ both 43.5375 3.59 50.5912 36.4838
NZB/BlNJ both 59.15 3.3846 65.8003 52.4997
NZW/LacJ both 50.1 3.3846 56.7503 43.4497
PERA/EiJ both 47.2014 3.6775 54.4271 39.9756
PL/J both 52.5833 3.9083 60.2624 44.9043
PWK/PhJ both 75.1667 3.8141 82.6607 67.6727
SEA/GnJ both 65.8492 3.2335 72.2026 59.4959
SJL/J both 51.85 3.3846 58.5003 45.1997
SM/J both 48.1889 3.4774 55.0214 41.3564
SPRET/EiJ both 37.2 3.4774 44.0325 30.3675
SWR/J both 38.2222 3.5677 45.2322 31.2122
WSB/EiJ both 49.6 3.59 56.6537 42.5463




  GWAS USING LINEAR MIXED MODELS