Intervention:   nicotine          

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg) Year
    Gould2 47101 drug and metabolite quantification nicotine plasma nicotine   [ng/mL]     acute 0.09mg dose    chronic 6.3mg dose inbred 8 m 8-12wks N=10 2011
    Gould2 47105 drug and metabolite quantification nicotine plasma cotinine   [ng/mL]     acute 0.09mg dose    chronic 6.3mg dose inbred 8 m 8-12wks N=10 2011
    Gould2 47111 behavior observation nicotine chronic group: grooming   [n]     control    nicotine inbred 8 m 8-12wks N=10 2011
    Gould2 47113 behavior observation nicotine chronic group: scratching   [n]     control    nicotine inbred 8 m 8-12wks N=10 2011
    Gould2 47115 behavior observation nicotine chronic group: jumping   [n]     control    nicotine inbred 8 m 8-12wks N=10 2011
    Gould2 47121 elevated plus maze nicotine chronic group: time in closed arms   [%]     control    nicotine inbred 8 m 8-12wks N=9 2011
    Gould2 47123 elevated plus maze nicotine chronic group: time in open arms   [%]     control    nicotine inbred 8 m 8-12wks N=9 2011
    Gould2 47125 elevated plus maze nicotine chronic group: time in center   [%]     control    nicotine inbred 8 m 8-12wks N=9 2011
    Gould2 47131 fear conditioning test nicotine acute group, conditioning: immediate fear   [%]     control    nicotine dose (mg):    0.045    0.09    0.18 inbred 8 m 8-12wks N=11 2011
    Gould2 47136 fear conditioning test nicotine acute group, conditioning: contextual fear   [%]     control    nicotine dose (mg):    0.045    0.09    0.18 inbred 8 m 8-12wks N=11 2011
    Gould2 47141 fear conditioning test nicotine acute group, cued fear: pre-cue   [%]     control    nicotine dose (mg):    0.045    0.09    0.18 inbred 8 m 8-12wks N=11 2011
    Gould2 47146 fear conditioning test nicotine acute group, cued fear: cue   [%]     control    nicotine dose (mg):    0.045    0.09    0.18 inbred 8 m 8-12wks N=11 2011
    Gould2 47151 fear conditioning test nicotine chronic group, conditioning: immediate fear   [%]     control    nicotine inbred 8 m 8-12wks N=10 2011
    Gould2 47156 fear conditioning test nicotine chronic group, conditioning: contextual fear   [%]     control    nicotine inbred 8 m 8-12wks N=10 2011
    Gould2 47161 fear conditioning test nicotine chronic group, cued fear: pre-cue   [%]     control    nicotine inbred 8 m 8-12wks N=10 2011
    Gould2 47166 fear conditioning test nicotine chronic group, cued fear: cue   [%]     control    nicotine inbred 8 m 8-12wks N=10 2011
    Gould3 47301 behavior observation nicotine withdrawal group: grooming   [n]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=11 2011
    Gould3 47306 behavior observation nicotine withdrawal group: scratching   [n]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=11 2011
    Gould3 47311 behavior observation nicotine withdrawal group: jumping   [n]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=11 2011
    Gould3 47321 elevated plus maze nicotine withdrawal group: time in closed arms   [%]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=10 2011
    Gould3 47326 elevated plus maze nicotine withdrawal group: time in open arms   [%]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=10 2011
    Gould3 47331 elevated plus maze nicotine withdrawal group: time in center   [%]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=10 2011
    Gould3 47341 fear conditioning test nicotine withdrawal group: conditioning: immediate fear   [%]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=12 2011
    Gould3 47346 fear conditioning test nicotine withdrawal group: conditioning: contextual fear   [%]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=12 2011
    Gould3 47361 fear conditioning test nicotine withdrawal group: cued fear: pre-cue   [%]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=12 2011
    Gould3 47366 fear conditioning test nicotine withdrawal group: cued fear: cue   [%]     control    nicotine dose (mg)    3    6.3    12 inbred 8 m 8-12wks N=12 2011
    Gould4 54701 conditioned place preference test nicotine preference trial 1   [s]     control    nicotine inbred 8 m 8-10wks N=9 2014
    Gould4 54711 conditioned place preference test nicotine preference trial 2   [s]     control    nicotine inbred 8 m 8-10wks N=9 2014
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