Intervention:   acetaminophen          

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg) Year
    Threadgill1 19401 organ weights acetaminophen liver weight   [g]     control    24h post-Rx mg/kg:    100    200    300 inbred w/CC7 37 m 8-17wks N=4 2005
    Threadgill1 19404 histopathology acetaminophen necrosis   [%]     control    post-Rx mg/kg:    100    200    300 inbred w/CC7 37 m 8-17wks N=3 2005
    Threadgill1 19406 metabolic panel acetaminophen  control alanine transaminase (serum ALT)   [IU/L]  ALT_ctrl inbred w/CC7 37 m 8-17wks N=2 2005
    Threadgill1 19407 metabolic panel acetaminophen  100mg/kg alanine transaminase (serum ALT), t=4h   [IU/L]  ALT_Rx100_4h inbred 7 m 8-17wks N=4 2005
    Threadgill1 19408 metabolic panel acetaminophen  100mg/kg alanine transaminase (serum ALT), t=12h   [IU/L]  ALT_Rx100_12h inbred 7 m 8-17wks N=4 2005
    Threadgill1 19409 metabolic panel acetaminophen  100mg/kg alanine transaminase (serum ALT), t=24h   [IU/L]  ALT_Rx100_24h inbred 7 m 8-17wks N=3 2005
    Threadgill1 19410 metabolic panel acetaminophen aspartate transaminase (serum AST)   [IU/L]     control    post-Rx mg/kg:    100    200    300 inbred w/CC7 37 m 8-17wks N=3 2005
    Threadgill1 19412 metabolic panel acetaminophen blood urea nitrogen (BUN)   [mg/dL]     control    post-Rx mg/kg:    100    200    300 inbred w/CC7 36 m 8-17wks N=3 2005
    Threadgill1 19414 metabolite quantification acetaminophen reduced glutathione (GSH)   [µmol/g]     control    post-Rx 300mg/kg inbred w/CC7 35 m 8-17wks N=3 2005
    Threadgill1 19416 metabolite quantification acetaminophen oxidized glutathione (GSSG)   [µmol/g]     control    post-Rx 300mg/kg inbred w/CC7 35 m 8-17wks N=3 2005
    Threadgill1 19418 metabolite quantification acetaminophen total glutathione (GSH plus GSSG)   [µmol/g]     control    post-Rx 300 mg/kg inbred w/CC7 35 m 8-17wks N=3 2005
    Threadgill1 19420 metabolite quantification acetaminophen ratio of reduced (GSH) to oxidized (GSSG) glutathione   [ratio]     control    post-Rx 300mg/kg inbred w/CC7 35 m 8-17wks N=3 2005
    Threadgill1 19482 metabolic panel acetaminophen catalase   [µg/mL]     control    post-Rx 300 mg/kg inbred w/CC7 37 m 8-12wks N=3 2005
    Threadgill1 19483 biomarker quantification acetaminophen cytochrome P450 1A2 isoform   [pmol/mg]     control    post-Rx 300 mg/kg inbred 36 m 8-12wks N=3 2005
    Threadgill1 19484 biomarker quantification acetaminophen cytochrome P450 2E1 isoform   [pmol/mg]     control    post-Rx 300 mg/kg inbred w/CC7 37 m 8-12wks N=3 2005
    Threadgill1 19486 metabolite quantification acetaminophen glutathione transferase   [µg/mL]     control    post-Rx 300 mg/kg inbred w/CC7 37 m 8-12wks N=3 2005
    Threadgill2 39602 metabolic panel acetaminophen alanine transaminase (serum ALT)   [IU/L]     50 mg/kg    300 mg/kg inbred 5 m 6-8wks N=5 2005
    Threadgill2 39603 histopathology acetaminophen  300mg/kg liver necrosis score   [%]  liver_necrosis inbred 5 m 6-8wks N=5 2005
    Threadgill2 39604 histopathology acetaminophen  300mg/kg percent nitrotyrosine staining (marker of hepatocyte injury)   [%]  pct_nitrotyrosine inbred 5 m 6-8wks N=5 2005
    Threadgill2 39605 metabolite quantification acetaminophen reduced glutathione (GSH)   [µmol/mg]     control    post-Rx 300 mg/kg inbred 5 m 6-8wks N=4 2005
    Threadgill2 39606 metabolite quantification acetaminophen percent reduced glutathione   [%]     control    post-Rx 300 mg/kg inbred 5 m 6-8wks N=4 2005
    Threadgill2 39607 metabolite quantification acetaminophen total glutathione   [µmol/mg]     control    post-Rx 300 mg/kg inbred 5 m 6-8wks N=4 2005
    Threadgill2 39609 drug and metabolite quantification acetaminophen serum acetaminophen (APAP)   [µg/mL]     baseline    0.5h    1h    2h    3h    6h inbred 5 m 6-8wks N=5 2005
    Threadgill2 39616 drug and metabolite quantification acetaminophen serum acetaminophen sulfate (APAP-sulfate)   [µg/mL]     baseline    0.5h    1h    2h    3h    6h inbred 5 m 6-8wks N=5 2005
    Threadgill2 39622 drug and metabolite quantification acetaminophen serum acetaminophen glucuronide (APAP-Glc)   [µg/mL]     baseline    0.5h    1h    2h    3h    6h inbred 5 m 6-8wks N=4 2005
    Threadgill2 39632 drug and metabolite quantification acetaminophen serum acetaminophen (APAP)   [µg/mL]     baseline    0.5h    1h    2h    3h    6h inbred 5 m 6-8wks N=5 2005
    Threadgill2 39638 drug and metabolite quantification acetaminophen serum acetaminophen sulfate (APAP-sulfate)   [µg/mL]     baseline    0.5h    1h    2h    3h    6h inbred 5 m 6-8wks N=5 2005
    Threadgill2 39639 drug and metabolite quantification acetaminophen serum acetaminophen glucuronide (APAP-Glc)   [µg/mL]     baseline    0.5h    1h    2h    3h    6h inbred 5 m 6-8wks N=5 2005
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