MPD: Measures involving acetaminophen

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Threadgill1:1	Threadgill1	organ weights	acetaminophen	liver weight 24h after treatment [g] liverwt 19401 dose (mg/kg): control 100 200 300	inbred w/CC7	37	m	8-17wks	N=4	2005

Threadgill1:4	Threadgill1	histopathology	acetaminophen	necrosis [%] liver_necrosis 19404 dose (mg/kg): control 100 200 300	inbred w/CC7	37	m	8-17wks	N=2	2005

Threadgill1:6	Threadgill1	metabolic panel	acetaminophen	alanine transaminase (serum ALT) [IU/L] ALT_ctrl 19406	inbred w/CC7	37	m	8-17wks	N=2	2005

Threadgill1:7	Threadgill1	metabolic panel	acetaminophen	alanine transaminase (serum ALT), t=4h [IU/L] ALT_Rx100_4h 19407	inbred w/CC7	7	m	8-17wks	N=4	2005

Threadgill1:8	Threadgill1	metabolic panel	acetaminophen	alanine transaminase (serum ALT), t=12h [IU/L] ALT_Rx100_12h 19408	inbred w/CC7	7	m	8-17wks	N=4	2005

Threadgill1:9	Threadgill1	metabolic panel	acetaminophen	alanine transaminase (serum ALT), t=24h [IU/L] ALT_Rx100_24h 19409	inbred w/CC7	7	m	8-17wks	N=3	2005

Threadgill1:10	Threadgill1	metabolic panel	acetaminophen	aspartate transaminase (serum AST) [IU/L] AST 19410 dose (mg/kg): control 100 200 300	inbred w/CC7	37	m	8-17wks	N=2	2005

Threadgill1:12	Threadgill1	metabolic panel	acetaminophen	blood urea nitrogen (serum BUN) [mg/dL] BUN 19412 dose (mg/kg) control 100 200 300	inbred w/CC7	37	m	8-17wks	N=2	2005

Threadgill1:14	Threadgill1	metabolite quantification	acetaminophen	reduced glutathione (GSH) [µmol/g] GSH 19414 control post-Rx 300mg/kg	inbred w/CC7	36	m	8-17wks	N=2	2005

Threadgill1:16	Threadgill1	metabolite quantification	acetaminophen	oxidized glutathione (GSSG) [µmol/g] GSSG 19416 control post-Rx 300mg/kg	inbred w/CC7	36	m	8-17wks	N=2	2005

Threadgill1:18	Threadgill1	metabolite quantification	acetaminophen	total glutathione (GSH plus GSSG) [µmol/g] GSH_total 19418 control post-Rx 300 mg/kg	inbred w/CC7	36	m	8-17wks	N=2	2005

Threadgill1:20	Threadgill1	metabolite quantification	acetaminophen	ratio of reduced (GSH) to oxidized (GSSG) glutathione [ratio] GSHratio 19420 control post-Rx 300mg/kg	inbred w/CC7	36	m	8-17wks	N=2	2005

Threadgill1:82	Threadgill1	metabolic panel	acetaminophen	catalase [µg/mL] catalase 19482 control post-Rx 300 mg/kg	inbred w/CC7	37	m	8-12wks	N=2	2005

Threadgill1:83	Threadgill1	biomarker quantification	acetaminophen	cytochrome P450 1A2 isoform [pmol/mg] CYP1A2 19483 control post-Rx 300 mg/kg	inbred w/CC7	37	m	8-12wks	N=2	2005

Threadgill1:84	Threadgill1	biomarker quantification	acetaminophen	cytochrome P450 2E1 isoform [pmol/mg] CYP2E1 19484 control post-Rx 300 mg/kg	inbred w/CC7	37	m	8-12wks	N=2	2005

Threadgill1:86	Threadgill1	metabolite quantification	acetaminophen	glutathione transferase [µg/mL] GSTpi 19486 control post-Rx 300 mg/kg	inbred w/CC7	37	m	8-12wks	N=2	2005

Threadgill2:2	Threadgill2	metabolic panel	acetaminophen	alanine transaminase (serum ALT) [IU/L] ALT 39602 50 mg/kg 300 mg/kg	inbred	5	m	6-8wks	N=5	2005

Threadgill2:3	Threadgill2	histopathology	acetaminophen	liver necrosis score [%] liver_necrosis 39603	inbred	5	m	6-8wks	N=5	2005

Threadgill2:4	Threadgill2	histopathology	acetaminophen	percent nitrotyrosine staining (marker of hepatocyte injury) [%] pct_nitrotyrosine 39604	inbred	5	m	6-8wks	N=5	2005

Threadgill2:5	Threadgill2	metabolite quantification	acetaminophen	reduced glutathione (GSH) [µmol/mg] GSH 39605 control post-Rx 300 mg/kg	inbred	5	m	6-8wks	N=4	2005

Threadgill2:6	Threadgill2	metabolite quantification	acetaminophen	percent reduced glutathione [%] GSH_pct 39606 control post-Rx 300 mg/kg	inbred	5	m	6-8wks	N=4	2005

Threadgill2:7	Threadgill2	metabolite quantification	acetaminophen	total glutathione [µmol/mg] GSH_total 39607 control post-Rx 300 mg/kg	inbred	5	m	6-8wks	N=4	2005

Threadgill2:9	Threadgill2	drug and metabolite quantification	acetaminophen	serum acetaminophen (APAP), 50 mg/mL dose acetaminophen [µg/mL] APAP50 39609 baseline 0.5h 1h 2h 3h 6h	inbred	5	m	6-8wks	N=5	2005

Threadgill2:16	Threadgill2	drug and metabolite quantification	acetaminophen	serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen [µg/mL] APAP_Sulf_50 39616 baseline 0.5h 1h 2h 3h 6h	inbred	5	m	6-8wks	N=5	2005

Threadgill2:22	Threadgill2	drug and metabolite quantification	acetaminophen	serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen [µg/mL] APAP_Glc_50 39622 baseline 0.5h 1h 2h 3h 6h	inbred	5	m	6-8wks	N=4	2005

Threadgill2:32	Threadgill2	drug and metabolite quantification	acetaminophen	serum acetaminophen (APAP), 300 mg/mL dose acetaminophen [µg/mL] APAP300 39632 baseline 0.5h 1h 2h 3h 6h	inbred	5	m	6-8wks	N=5	2005

Threadgill2:38	Threadgill2	drug and metabolite quantification	acetaminophen	serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen [µg/mL] APAP_Sulf_300 39638 baseline 0.5h 1h 2h 3h 6h	inbred	5	m	6-8wks	N=5	2005

Threadgill2:39	Threadgill2	drug and metabolite quantification	acetaminophen	serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen [µg/mL] APAP_Glc_300 39639 baseline 0.5h 1h 2h 3h 6h	inbred	5	m	6-8wks	N=5	2005

Threadgill1

organ weights

acetaminophen

liver weight 24h after treatment [g] liverwt 19401 dose (mg/kg): control 100 200 300

inbred w/CC7

37

m

8-17wks

N=4

2005

Threadgill1

histopathology

acetaminophen

necrosis [%] liver_necrosis 19404 dose (mg/kg): control 100 200 300

inbred w/CC7

37

m

8-17wks

N=2

2005

Threadgill1

metabolic panel

acetaminophen

alanine transaminase (serum ALT) [IU/L] ALT_ctrl 19406

inbred w/CC7

37

m

8-17wks

N=2

2005

Threadgill1

metabolic panel

acetaminophen

alanine transaminase (serum ALT), t=4h [IU/L] ALT_Rx100_4h 19407

inbred w/CC7

7

m

8-17wks

N=4

2005

Threadgill1

metabolic panel

acetaminophen

alanine transaminase (serum ALT), t=12h [IU/L] ALT_Rx100_12h 19408

inbred w/CC7

7

m

8-17wks

N=4

2005

Threadgill1

metabolic panel

acetaminophen

alanine transaminase (serum ALT), t=24h [IU/L] ALT_Rx100_24h 19409

inbred w/CC7

7

m

8-17wks

N=3

2005

Threadgill1

metabolic panel

acetaminophen

aspartate transaminase (serum AST) [IU/L] AST 19410 dose (mg/kg): control 100 200 300

inbred w/CC7

37

m

8-17wks

N=2

2005

Threadgill1

metabolic panel

acetaminophen

blood urea nitrogen (serum BUN) [mg/dL] BUN 19412 dose (mg/kg) control 100 200 300

inbred w/CC7

37

m

8-17wks

N=2

2005

Threadgill1

metabolite quantification

acetaminophen

reduced glutathione (GSH) [µmol/g] GSH 19414 control post-Rx 300mg/kg

inbred w/CC7

36

m

8-17wks

N=2

2005

Threadgill1

metabolite quantification

acetaminophen

oxidized glutathione (GSSG) [µmol/g] GSSG 19416 control post-Rx 300mg/kg

inbred w/CC7

36

m

8-17wks

N=2

2005

Threadgill1

metabolite quantification

acetaminophen

total glutathione (GSH plus GSSG) [µmol/g] GSH_total 19418 control post-Rx 300 mg/kg

inbred w/CC7

36

m

8-17wks

N=2

2005

Threadgill1

metabolite quantification

acetaminophen

ratio of reduced (GSH) to oxidized (GSSG) glutathione [ratio] GSHratio 19420 control post-Rx 300mg/kg

inbred w/CC7

36

m

8-17wks

N=2

2005

Threadgill1

metabolic panel

acetaminophen

catalase [µg/mL] catalase 19482 control post-Rx 300 mg/kg

inbred w/CC7

37

m

8-12wks

N=2

2005

Threadgill1

biomarker quantification

acetaminophen

cytochrome P450 1A2 isoform [pmol/mg] CYP1A2 19483 control post-Rx 300 mg/kg

inbred w/CC7

37

m

8-12wks

N=2

2005

Threadgill1

biomarker quantification

acetaminophen

cytochrome P450 2E1 isoform [pmol/mg] CYP2E1 19484 control post-Rx 300 mg/kg

inbred w/CC7

37

m

8-12wks

N=2

2005

Threadgill1

metabolite quantification

acetaminophen

glutathione transferase [µg/mL] GSTpi 19486 control post-Rx 300 mg/kg

inbred w/CC7

37

m

8-12wks

N=2

2005

Threadgill2

metabolic panel

acetaminophen

alanine transaminase (serum ALT) [IU/L] ALT 39602 50 mg/kg 300 mg/kg

inbred

5

m

6-8wks

N=5

2005

Threadgill2

histopathology

acetaminophen

liver necrosis score [%] liver_necrosis 39603

inbred

5

m

6-8wks

N=5

2005

Threadgill2

histopathology

acetaminophen

percent nitrotyrosine staining (marker of hepatocyte injury) [%] pct_nitrotyrosine 39604

inbred

5

m

6-8wks

N=5

2005

Threadgill2

metabolite quantification

acetaminophen

reduced glutathione (GSH) [µmol/mg] GSH 39605 control post-Rx 300 mg/kg

inbred

5

m

6-8wks

N=4

2005

Threadgill2

metabolite quantification

acetaminophen

percent reduced glutathione [%] GSH_pct 39606 control post-Rx 300 mg/kg

inbred

5

m

6-8wks

N=4

2005

Threadgill2

metabolite quantification

acetaminophen

total glutathione [µmol/mg] GSH_total 39607 control post-Rx 300 mg/kg

inbred

5

m

6-8wks

N=4

2005

Threadgill2

drug and metabolite quantification

acetaminophen

serum acetaminophen (APAP), 50 mg/mL dose acetaminophen [µg/mL] APAP50 39609 baseline 0.5h 1h 2h 3h 6h

inbred

5

m

6-8wks

N=5

2005

Threadgill2

drug and metabolite quantification

acetaminophen

serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen [µg/mL] APAP_Sulf_50 39616 baseline 0.5h 1h 2h 3h 6h

inbred

5

m

6-8wks

N=5

2005

Threadgill2

drug and metabolite quantification

acetaminophen

serum acetaminophen glucuronide (APAP-Glc), 50 mg/mL dose acetaminophen [µg/mL] APAP_Glc_50 39622 baseline 0.5h 1h 2h 3h 6h

inbred

5

m

6-8wks

N=4

2005

Threadgill2

drug and metabolite quantification

acetaminophen

serum acetaminophen (APAP), 300 mg/mL dose acetaminophen [µg/mL] APAP300 39632 baseline 0.5h 1h 2h 3h 6h

inbred

5

m

6-8wks

N=5

2005

Threadgill2

drug and metabolite quantification

acetaminophen

serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen [µg/mL] APAP_Sulf_300 39638 baseline 0.5h 1h 2h 3h 6h

inbred

5

m

6-8wks

N=5

2005

Threadgill2

drug and metabolite quantification

acetaminophen

serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen [µg/mL] APAP_Glc_300 39639 baseline 0.5h 1h 2h 3h 6h

inbred

5

m

6-8wks

N=5

2005

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