MPD - Projects that involve: liver

Projects that involve: liver–pathology

Each of the projects below has phenotype data in MPD.
Links are available for data, protocols, and publications.

Klaassen1 Data Protocol
Klaassen CD Cadmium toxicity in the testes, liver, and trigeminal ganglia in males of 8 inbred strains of mice

Habeebu SS, Liu Y, Park JD, Klaassen CD. Strain differences in the toxicity of cadmium to trigeminal ganglia in mice. Toxicol Appl Pharmacol. 2001 Dec 15;177(3):200-7. PubMed 11749119 MGI FullText

Paigen1 Data Protocol
Paigen B, Bouchard G, Carey MC Diet effects on gallstone formation and the assessment of liver morphology, plasma lipids, and atherosclerosis in 44 inbred strains of mice on high-fat atherogenic diet (not under pathogen-free conditions)

Paigen3 Data Protocol
Paigen B, Bouchard G, Carey MC Diet effects on gallstone formation, liver pathology, plasma lipids, and pathogen-accelerated atherosclerosis in 8 obesity mutant mouse strains

Bouchard G, Johnson D, Carver T, Paigen B, Carey MC. Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk. J Lipid Res. 2002 Jul;43(7):1105-13. PubMed 12091495 MGI FullText

Rusyn5 Data Protocol
Rusyn I Drug study: High-fat diet plus subchronic alcohol-induced effects in males of 14 inbred strains of mice

Tsuchiya M, Ji C, Kosyk O, Shymonyak S, Melnyk S, Kono H, Tryndyak V, Muskhelishvili L, Pogribny IP, Kaplowitz N, Rusyn I. Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology. 2012 Jul;56(1):130-9. doi: 10.1002/hep.2564Epub 2012 Jun 6. PubMed 22307928 MGI FullText

Threadgill1 Data Protocol
Threadgill DW, Harrill A, Rusyn I Drug study: Toxicogenetic survey of susceptibility to acetaminophen-induced liver injury in males of 37 inbred strains of mice

Harrill AH, Ross PK, Gatti DM, Threadgill DW, Rusyn I. Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicol Sci. 2009 Jul;110(1):235-43. Epub 2009 May 6. PubMed 19420014 MGI FullText

Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW. Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Res. 2009 Sep;19(9):1507-15. Epub 2009 May 5. PubMed 19416960 MGI FullText

Threadgill2 Data Protocol
Threadgill DW, Harrill A Drug study: Acetaminophen pharmakokinetics and drug-induced liver injury in males of 5 inbred strains of mice

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