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Projects that involve: liver

Each of the projects below has phenotype data in MPD.
Links are available for data, protocols, and publications.

Cheverud1     Data     Protocol    
Cheverud JM     Diet-induced obesity and diabetes in 19 LGXSM recombinant inbred strains of mice
  Cheverud JM, Ehrich TH, Kenney JP, Pletscher LS, Semenkovich CF. Genetic evidence for discordance between obesity- and diabetes-related traits in the LGXSM recombinant inbred mouse strains. Diabetes. 2004 Oct;53(10):2700-8.     PubMed 15448104     MGI     FullText

Hrbek T, de Brito RA, Wang B, Pletscher LS, Cheverud JM. Genetic characterization of a new set of recombinant inbred lines (LGXSM) formed from the inter-cross of SM/J and LG/J inbred mouse strains. Mamm Genome. 2006 May;17(5):417-29.     PubMed 16688532     MGI     FullText



Harrill2     Data     Protocol    
Harrill A     Drug study: Survey of kidney injury due to DB289 treatment in females of 34 inbred strains of mice
  Harrill AH, Desmet KD, Wolf KK, Bridges AS, Eaddy JS, Kurtz CL, Hall JE, Paine MF, Tidwell RR, Watkins PB. A Mouse Diversity Panel Approach Reveals the Potential for Clinical Kidney Injury Due to DB289 Not Predicted by Classical Rodent Models. Toxicol Sci. 2012 Dec;130(2):416-26. doi: 10.1093/toxsci/kfs238. Epub 2012 Aug 31.     PubMed 22940726     MGI     FullText



Jaxpheno2     Data     Protocol    
Jackson Laboratory     Morphometric (organ weight) survey of 11 inbred strains of mice


Klaassen1     Data     Protocol    
Klaassen CD     Cadmium toxicity in the testes, liver, and trigeminal ganglia in males of 8 inbred strains of mice
  Habeebu SS, Liu Y, Park JD, Klaassen CD. Strain differences in the toxicity of cadmium to trigeminal ganglia in mice. Toxicol Appl Pharmacol. 2001 Dec 15;177(3):200-7.     PubMed 11749119     MGI     FullText



Paigen1     Data     Protocol    
Paigen B, Bouchard G, Carey MC     Diet effects on gallstone formation and the assessment of liver morphology, plasma lipids, and atherosclerosis in 44 inbred strains of mice on high-fat atherogenic diet (not under pathogen-free conditions)


Paigen3     Data     Protocol    
Paigen B, Bouchard G, Carey MC     Diet effects on gallstone formation, liver pathology, plasma lipids, and pathogen-accelerated atherosclerosis in 8 obesity mutant mouse strains
  Bouchard G, Johnson D, Carver T, Paigen B, Carey MC. Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk. J Lipid Res. 2002 Jul;43(7):1105-13.     PubMed 12091495     MGI     FullText



Rusyn5     Data     Protocol    
Rusyn I     Drug study: High-fat diet plus subchronic alcohol-induced effects in males of 14 inbred strains of mice
  Tsuchiya M, Ji C, Kosyk O, Shymonyak S, Melnyk S, Kono H, Tryndyak V, Muskhelishvili L, Pogribny IP, Kaplowitz N, Rusyn I. Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology. 2012 Jul;56(1):130-9. doi: 10.1002/hep.2564Epub 2012 Jun 6.     PubMed 22307928     MGI     FullText



Schonfeld1     Data     Protocol    
Schonfeld G     Strain survey of liver and plasma lipids and blood glucose levels in 11 inbred strains of mice
  Lin X, Yue P, Chen Z, Schonfeld G. Hepatic triglyceride contents are genetically determined in mice: results of a strain survey. Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1179-89. Epub 2004 Dec 9.     PubMed 15591160     MGI     FullText



Threadgill1     Data     Protocol    
Threadgill DW, Harrill A, Rusyn I     Drug study: Toxicogenetic survey of susceptibility to acetaminophen-induced liver injury in males of 37 inbred strains of mice
  Harrill AH, Ross PK, Gatti DM, Threadgill DW, Rusyn I. Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicol Sci. 2009 Jul;110(1):235-43. Epub 2009 May 6.     PubMed 19420014     MGI     FullText

Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW. Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Res. 2009 Sep;19(9):1507-15. Epub 2009 May 5.     PubMed 19416960     MGI     FullText



Threadgill2     Data     Protocol    
Threadgill DW, Harrill A     Drug study: Acetaminophen pharmakokinetics and drug-induced liver injury in males of 5 inbred strains of mice
  Harrill AH, Ross PK, Gatti DM, Threadgill DW, Rusyn I. Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicol Sci. 2009 Jul;110(1):235-43. Epub 2009 May 6.     PubMed 19420014     MGI     FullText

Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW. Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Res. 2009 Sep;19(9):1507-15. Epub 2009 May 5.     PubMed 19416960     MGI     FullText



Vulpe1     Data     Protocol    
McLachlan S, Vulpe CD     Basal liver mineral levels and iron homeostasis in 18 diverse mouse strains
  McLachlan S, Lee SM, Steele TM, Hawthorne PL, Zapala MA, Eskin E, Schork NJ, Anderson GJ, Vulpe CD. In silico QTL mapping of basal liver iron levels in inbred mouse strains. Physiol Genomics. 2011 Feb 11;43(3):136-47. Epub 2010 Nov 9.     PubMed 21062905     MGI     FullText



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