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Projects that involve: immune system

Each of the projects below has phenotype data in MPD.
Links are available for data, protocols, and publications.

Benoist1     Data     Protocol    
Benoist C, Mathis D, Satpathy A, Feuerer M     Survey of regulatory T cells (Treg) of the thymus and spleen in males of 33 inbred strains of mice
  Feuerer M, Jiang W, Holler PD, Satpathy A, Campbell C, Bogue M, Mathis D, Benoist C. Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18181-6. Epub 2007 Nov 8.     PubMed 17991775     MGI     FullText



Boon1     Data     Protocol    
Boon AC, Webby RJ     Susceptibility to influenza A (H5N1) viral infection in females of 23 strains of mice
  Boon AC, Finkelstein D, Zheng M, Liao G, Allard J, Klumpp K, Webster R, Peltz G, Webby RJ. H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load. MBio. 2011 Sep 6;2(5). pii: e00171-1doi: 10.1128/mBio.00171-1Print 2011.     PubMed 21896679     MGI     FullText



Bopp1     Data     Protocol    
Bopp SE, Ramachandran V, Wiltshire T, Winzeler EA     Malaria survival in 31 inbred mouse strains
  Bopp SE, Ramachandran V, Henson K, Luzader A, Lindstrom M, Spooner M, Steffy BM, Suzuki O, Janse C, Waters AP, Zhou Y, Wiltshire T, Winzeler EA. Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival. PLoS One. 2010 May 28;5(5):e10903.     PubMed 20531941     MGI     FullText



Deschepper1     Data     Protocol    
Deschepper CF, Gallo-Payet N     Systolic blood pressure and multi-organ morphologic characterization in 13 inbred strains of mice
  Deschepper CF, Olson JL, Otis M, Gallo-Payet N. Characterization of blood pressure and morphological traits in cardiovascular-related organs in 13 different inbred mouse strains. J Appl Physiol. 2004 Jul;97(1):369-76. Epub 2004 Mar 26.     PubMed 15047670     MGI     FullText



Dietrich1     Data     Protocol    
Dietrich WF     Bacillus anthracis lethal toxin susceptibility in females of 50 strains of mice
  Boyden ED, Dietrich WF. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet. 2006 Feb;38(2):240-4. Epub 2006 Jan 22.     PubMed 16429160     MGI     FullText

Roberts JE, Watters JW, Ballard JD, Dietrich WF. Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11. Mol Microbiol. 1998 Jul;29(2):581-91.     PubMed 9720874     MGI     FullText

Watters JW, Dewar K, Lehoczky J, Boyartchuk V, Dietrich WF. Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor. Curr Biol. 2001 Oct 2;11(19):1503-11.     PubMed 11591317     MGI     FullText

Watters JW, Dietrich WF. Genetic, physical, and transcript map of the Ltxs1 region of mouse chromosome 11. Genomics. 2001 Apr 15;73(2):223-31.     PubMed 11318612     MGI     FullText



Donahue5     Data     Protocol    
Donahue L     Peripheral blood leukocytes in C57BL/6J-Chr#A/J/NaJ mouse chromosome substitution strains


Donahue6     Data     Protocol    
Donahue L     Peripheral blood leukocytes in C57BL/6J-Chr#PWD/Ph/ForeJ mouse chromosome substitution strains


Donahue7     Data     Protocol    
Donahue L     Plasma immunoglobulin concentrations in C57BL/6J-Chr#A/J/NaJ mouse chromosome substitution strains


Donahue8     Data     Protocol    
Donahue L     Plasma immunoglobulin concentrations in C57BL/6J-Chr#PWD/Ph/ForeJ mouse chromosome substitution strains


Eumorphia7     Data     Protocol    
Eumorphia / Europhenome     Serum immunoglobulin concentrations in 6 inbred strains of mice


Gros1     Data     Protocol    
Radovanovic I, Mullick A, Gros P     Susceptibility to infection with Candida albicans in females of 23 inbred strains of mice (and C5-allele status in 36 strains)
  Radovanovic I, Mullick A, Gros P. Genetic control of susceptibility to infection with Candida albicans in mice. PLoS One. 2011 Apr 20;6(4):e18957.     PubMed 21533108     MGI     FullText



Jax2     Data     Protocol    
Jackson Laboratory     Major histocompatibility complex (MHC) H2 haplotypes for 56 inbred strains of mice


Jaxpheno6     Data     Protocol    
Jackson Laboratory     Flow-cytometric analysis of 11 inbred strains of mice


Petkova1     Data     Protocol    
Petkova S, Roopenian D     Aging study: Peripheral blood leukocytes (PBL profiles) in 32 inbred strains of mice
  Petkova SB, Yuan R, Tsaih SW, Schott W, Roopenian DC, Paigen B. Genetic influence on immune phenotype revealed strain-specific variations in peripheral blood lineages. Physiol Genomics. 2008 Aug 15;34(3):304-14. Epub 2008 Jun 10.     PubMed 18544662     MGI     FullText



Schughart1     Data     Protocol    
Schughart K     Susceptibility to influenza A (H1N1) viral infection in females of 9 strains of mice
  Srivastava B, Błazejewska P, Hessmann M, Bruder D, Geffers R, Mauel S, Gruber AD, Schughart K. Host genetic background strongly influences the response to influenza a virus infections. PLoS One. 2009;4(3):e4857. Epub 2009 Mar 18.     PubMed 19293935     MGI     FullText



Williams1     Data     Protocol    
Williams RB     Inter-strain variation in splenocyte populations for 5 inbred strains (Australia ARC)


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