MPD - Projects that involve: blood

Projects that involve: blood–xenobiotics

Each of the projects below has phenotype data in MPD.
Links are available for data, protocols, and publications.

Bennett3 Data Protocol
Bennett B, Johnson TE Acute functional tolerance to ethanol in 74 ILSXISS recombinant inbred strains of mice

Bennett B, Downing C, Carosone-Link P, Ponicsan H, Ruf C, Johnson TE. Quantitative trait locus mapping for acute functional tolerance to ethanol in the L x S recombinant inbred panel. Alcohol Clin Exp Res. 2007 Feb;31(2):200-8. PubMed 17250610 MGI FullText

Crabbe4 Data Protocol
Crabbe JC, Metten P, Wahlsten D Drug study: Measurement of ethanol sensitivity and intoxication using performances in the screen, dowel, and grip strength tests, in 21 inbred strains of mice

Crabbe JC, Cotnam CJ, Cameron AJ, Schlumbohm JP, Rhodes JS, Metten P, Wahlsten D. Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests. Genes Brain Behav. 2003 Aug;2(4):201-13. PubMed 12953786 MGI FullText

Crowley1 Data Protocol
Crowley JJ, McLeod HL, Sullivan PF Drug study: Haloperidol-induced vacuous chewing movements, extrapyramidal side effects, and spontaneous locomotor activity in males of 27 inbred mouse strains

Crowley JJ, Adkins DE, Pratt AL, Quackenbush CR, van den Oord EJ, Moy SS, Wilhelmsen KC, Cooper TB, Bogue MA, McLeod HL, Sullivan PF. Antipsychotic-induced vacuous chewing movements and extrapyramidal side effects are highly heritable in mice. Pharmacogenomics J. 2012 Apr;12(2):147-55. doi: 10.1038/tpj.2010.82. Epub 2010 Nov 16. PubMed 21079646 MGI FullText

Gould1 Data Protocol
Can A, Gould TD Drug study: Antidepressant-like responses to lithium in males of 8 inbred mouse strains and 3 outbred stocks

Can A, Blackwell RA, Piantadosi SC, Dao DT, O'Donnell KC, Gould TD. Antidepressant-like responses to lithium in genetically diverse mouse strains. Genes Brain Behav. 2011 Jun;10(4):434-43. doi: 10.1111/j.1601-183X.2011.00682.x. Epub 2011 Mar 1. PubMed 21306560 MGI FullText

Gould2 Data Protocol
Portugal GS, Gould TJ Effects of acute and chronic nicotine on fear conditioning and other behaviors in males of 8 inbred mouse strains

Portugal GS, Wilkinson DS, Kenney JW, Sullivan C, Gould TJ. Strain-dependent Effects of Acute, Chronic, and Withdrawal from Chronic Nicotine on Fear Conditioning. Behav Genet. 2012 Jan;42(1):133-50. Epub 2011 Aug 6. PubMed 21822688 MGI FullText

Rusyn2 Data Protocol
Rusyn I, Threadgill DW Effects of trichloroethylene in males of 17 inbred mouse strains

Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, Desimone M, Threadgill DW, Tryndyak V, Pogribny IP, Bleyle L, Koop DR, Rusyn I. Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. Toxicol Sci. 2011 Mar;120(1):206-17. Epub 2010 Dec 6. PubMed 21135412 MGI FullText

Rusyn5 Data Protocol
Rusyn I Drug study: High-fat diet plus subchronic alcohol-induced effects in males of 14 inbred strains of mice

Tsuchiya M, Ji C, Kosyk O, Shymonyak S, Melnyk S, Kono H, Tryndyak V, Muskhelishvili L, Pogribny IP, Kaplowitz N, Rusyn I. Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology. 2012 Jul;56(1):130-9. doi: 10.1002/hep.2564Epub 2012 Jun 6. PubMed 22307928 MGI FullText

Threadgill2 Data Protocol
Threadgill DW, Harrill A Drug study: Acetaminophen pharmakokinetics and drug-induced liver injury in males of 5 inbred strains of mice

Harrill AH, Ross PK, Gatti DM, Threadgill DW, Rusyn I. Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicol Sci. 2009 Jul;110(1):235-43. Epub 2009 May 6. PubMed 19420014 MGI FullText

Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW. Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Res. 2009 Sep;19(9):1507-15. Epub 2009 May 5. PubMed 19416960 MGI FullText

Wiltshire2 Data Protocol
Wiltshire T, Pletcher MT Drug study: Behavioral responses to chronic fluoxetine treatment in males of 30 inbred mouse strains

Benton CS, Miller BH, Skwerer S, Suzuki O, Schultz LE, Cameron MD, Marron JS, Pletcher MT, Wiltshire T. Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains. Psychopharmacology (Berl). 2012 May;221(2):297-315. Epub 2011 Nov 24. PubMed 22113448 MGI FullText

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