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Projects that involve: blood–clinical chemistry
Each of the projects below has phenotype data in MPD.
Links are available for data, protocols, and publications.
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Berndt3
Data
Protocol
Berndt A Serum vitamin D levels in males of 18 inbred mouse strains
Berndt A, Savage HS, Stearns TM, Paigen B. Genetic analysis of lung function in inbred mice suggests vitamin D receptor as a candidate gene. Mol Genet Genomics. 2011 Oct;286(3-4):237-46. Epub 2011 Aug 19.
PubMed 21850575
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CGDpheno1
Data
Protocol
Center for Genome Dynamics (CGD) Multi-system survey of mouse physiology in 72 inbred strains of mice (ANOVA-adjusted methodology)
CGDpheno3
Data
Protocol
Center for Genome Dynamics Multi-system survey of mouse physiology in 8 inbred founder strains and 54 F1 hybrids of the Collaborative Cross
Lenarcic AB, Svenson KL, Churchill GA, Valdar W. A general Bayesian approach to analyzing diallel crosses of inbred strains. Genetics. 2012 Feb;190(2):413-35.
PubMed 22345610
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Chesler2
Data
Protocol
Chesler EJ, Philip VM, Voy BH Multi-system assessment of 8 inbred founder strains and 54 F1 hybrids of the Collaborative Cross
Philip VM, Sokoloff G, Ackert-Bicknell CL, Striz M, Branstetter L, Beckmann MA, Spence JS, Jackson BL, Galloway LD, Barker P, Wymore AM, Hunsicker PR, Durtschi DC, Chesler EJ, et al. Genetic analysis in the Collaborative Cross breeding population. Genome Res. 2011 Aug;21(8):1223-38. Epub 2011 Jul 6.
PubMed 21734011
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Chesler3
Data
Protocol
Chesler EJ, Philip VM, Voy BH Multi-system assessment of 8 inbred founder strains and 380+ emerging lines (pre-CC) of the Collaborative Cross
Philip VM, Sokoloff G, Ackert-Bicknell CL, Striz M, Branstetter L, Beckmann MA, Spence JS, Jackson BL, Galloway LD, Barker P, Wymore AM, Hunsicker PR, Durtschi DC, Chesler EJ, et al. Genetic analysis in the Collaborative Cross breeding population. Genome Res. 2011 Aug;21(8):1223-38. Epub 2011 Jul 6.
PubMed 21734011
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Cheverud1
Data
Protocol
Cheverud JM Diet-induced obesity and diabetes in 19 LGXSM recombinant inbred strains of mice
Cheverud JM, Ehrich TH, Kenney JP, Pletscher LS, Semenkovich CF. Genetic evidence for discordance between obesity- and diabetes-related traits in the LGXSM recombinant inbred mouse strains. Diabetes. 2004 Oct;53(10):2700-8.
PubMed 15448104
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Hrbek T, de Brito RA, Wang B, Pletscher LS, Cheverud JM. Genetic characterization of a new set of recombinant inbred lines (LGXSM) formed from the inter-cross of SM/J and LG/J inbred mouse strains. Mamm Genome. 2006 May;17(5):417-29.
PubMed 16688532
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Donahue9
Data
Protocol
Donahue L Blood chemistry of C57BL/6J-Chr#
PWD/Ph
/ForeJ mouse chromosome substitution strains
Eumorphia1
Data
Protocol
Eumorphia / Europhenome Blood chemistry and hematology in 8 inbred strains of mice
Champy MF, Selloum M, Zeitler V, Caradec C, Jung B, Rousseau S, Pouilly L, Sorg T, Auwerx J. Genetic background determines metabolic phenotypes in the mouse. Mamm Genome. 2008 May;19(5):318-3Epub 2008 Apr 5.
PubMed 18392653
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Eumorphia3
Data
Protocol
Eumorphia / Europhenome Glucose tolerance test in 4 inbred strains of mice
Champy MF, Selloum M, Zeitler V, Caradec C, Jung B, Rousseau S, Pouilly L, Sorg T, Auwerx J. Genetic background determines metabolic phenotypes in the mouse. Mamm Genome. 2008 May;19(5):318-3Epub 2008 Apr 5.
PubMed 18392653
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Harrill2
Data
Protocol
Harrill A Drug study: Survey of kidney injury due to DB289 treatment in females of 34 inbred strains of mice
Harrill AH, Desmet KD, Wolf KK, Bridges AS, Eaddy JS, Kurtz CL, Hall JE, Paine MF, Tidwell RR, Watkins PB. A Mouse Diversity Panel Approach Reveals the Potential for Clinical Kidney Injury Due to DB289 Not Predicted by Classical Rodent Models. Toxicol Sci. 2012 Dec;130(2):416-26. doi: 10.1093/toxsci/kfs238. Epub 2012 Aug 31.
PubMed 22940726
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Jaxpheno3
Data
Protocol
Jackson Laboratory Blood chemistry survey of 11 inbred strains of mice
Lake1
Data
Protocol
Lake J, Donahue L, Davisson MT Multi-system analysis of mouse physiology, C57BL/6J-Chr#
A/J
/NaJ chromosome substitution panel
Naggert1
Data
Protocol
Naggert J, Svenson KL, Smith RV, Paigen B, Peters LL Diet effects on bone mineral density and content, body composition, and plasma glucose, leptin, and insulin levels in 43 inbred strains of mice on a high-fat atherogenic diet
Li R, Svenson KL, Donahue LR, Peters LL, Churchill GA. Relationships of dietary fat, body composition, and bone mineral density in inbred mouse strain panels. Physiol Genomics. 2008 Mar 14;33(1):26-32. Epub 2008 Jan 29.
PubMed 18230669
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Svenson KL, Von Smith R, Magnani PA, Suetin HR, Paigen B, Naggert JK, Li R, Churchill GA, Peters LL. Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations. J Appl Physiol. 2007 Jun;102(6):2369-78. Epub 2007 Feb 22.
PubMed 17317875
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Paigen1
Data
Protocol
Paigen B, Bouchard G, Carey MC Diet effects on gallstone formation and the assessment of liver morphology, plasma lipids, and atherosclerosis in 44 inbred strains of mice on high-fat atherogenic diet (not under pathogen-free conditions)
Paigen3
Data
Protocol
Paigen B, Bouchard G, Carey MC Diet effects on gallstone formation, liver pathology, plasma lipids, and pathogen-accelerated atherosclerosis in 8 obesity mutant mouse strains
Bouchard G, Johnson D, Carver T, Paigen B, Carey MC. Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk. J Lipid Res. 2002 Jul;43(7):1105-13.
PubMed 12091495
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Peters1
Data
Protocol
Peters LL, Barker JE Hematology and clotting time survey in 43 inbred strains of mice
Peters LL, Cheever EM, Ellis HR, Magnani PA, Svenson KL, Von Smith R, Bogue MA. Large-scale, high-throughput screening for coagulation and hematologic phenotypes in mice. Physiol Genomics. 2002 Dec 3;11(3):185-93.
PubMed 12419856
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RIKEN-EAD1
Data
Protocol
RIKEN BioResource Center / Experimental Animal Division Blood chemistry, hematology, and body size for 56 inbred mouse strains (RBRC)
RIKEN-EAD2
Data
Protocol
RIKEN BioResource Center / Experimental Animal Division Blood chemistry, hematology, and body size for 33 RBRC wild-derived mouse strains
Rusyn2
Data
Protocol
Rusyn I, Threadgill DW Effects of trichloroethylene in males of 17 inbred mouse strains
Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, Desimone M, Threadgill DW, Tryndyak V, Pogribny IP, Bleyle L, Koop DR, Rusyn I. Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. Toxicol Sci. 2011 Mar;120(1):206-17. Epub 2010 Dec 6.
PubMed 21135412
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Rusyn5
Data
Protocol
Rusyn I Drug study: High-fat diet plus subchronic alcohol-induced effects in males of 14 inbred strains of mice
Tsuchiya M, Ji C, Kosyk O, Shymonyak S, Melnyk S, Kono H, Tryndyak V, Muskhelishvili L, Pogribny IP, Kaplowitz N, Rusyn I. Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology. 2012 Jul;56(1):130-9. doi: 10.1002/hep.2564Epub 2012 Jun 6.
PubMed 22307928
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Schonfeld1
Data
Protocol
Schonfeld G Strain survey of liver and plasma lipids and blood glucose levels in 11 inbred strains of mice
Lin X, Yue P, Chen Z, Schonfeld G. Hepatic triglyceride contents are genetically determined in mice: results of a strain survey. Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1179-89. Epub 2004 Dec 9.
PubMed 15591160
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Shockley1
Data
Protocol
Shockley K, Paigen B, Churchill GA Diet effects on blood chemistry and lipids in 10 inbred strains of mice
Shockley KR, Witmer D, Burgess-Herbert SL, Paigen B, Churchill GA. Effects of atherogenic diet on hepatic gene expression across mouse strains. Physiol Genomics. 2009 Nov 6;39(3):172-82. Epub 2009 Aug 11.
PubMed 19671657
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Svenson3
Data
Protocol
Svenson KL, Forejt J, Donahue L, Paigen B Hematology and blood chemistry of C57BL/6J-Chr#
PWD/Ph
/ForeJ mouse chromosome substitution strains
Gregorová S, Divina P, Storchova R, Trachtulec Z, Fotopulosova V, Svenson KL, Donahue LR, Paigen B, Forejt J. Mouse consomic strains: exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies. Genome Res. 2008 Mar;18(3):509-15. Epub 2008 Feb 6.
PubMed 18256238
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Threadgill1
Data
Protocol
Threadgill DW, Harrill A, Rusyn I Drug study: Toxicogenetic survey of susceptibility to acetaminophen-induced liver injury in males of 37 inbred strains of mice
Harrill AH, Ross PK, Gatti DM, Threadgill DW, Rusyn I. Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicol Sci. 2009 Jul;110(1):235-43. Epub 2009 May 6.
PubMed 19420014
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Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW. Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Res. 2009 Sep;19(9):1507-15. Epub 2009 May 5.
PubMed 19416960
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Threadgill2
Data
Protocol
Threadgill DW, Harrill A Drug study: Acetaminophen pharmakokinetics and drug-induced liver injury in males of 5 inbred strains of mice
Harrill AH, Ross PK, Gatti DM, Threadgill DW, Rusyn I. Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicol Sci. 2009 Jul;110(1):235-43. Epub 2009 May 6.
PubMed 19420014
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Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW. Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Res. 2009 Sep;19(9):1507-15. Epub 2009 May 5.
PubMed 19416960
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Tomasini1
Data
Protocol
Tomasini-Johansson BR, Mosher DF A survey of plasma fibronectin concentration in 25 inbred strains of mice
Tomasini-Johansson B, Mosher DF. Plasma fibronectin concentration in inbred mouse strains. Thromb Haemost. 2009 Dec;102(6):1278-80.
PubMed 19967162
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Tordoff3
Data
Protocol
Tordoff MG, Bachmanov AA Diet preference: Survey of calcium and sodium intake, blood pH and calcium level, and bone and body composition data in 40 inbred strains of mice
Reed DR, Bachmanov AA, Tordoff MG. Forty mouse strain survey of body composition. Physiol Behav. 2007 Aug 15;91(5):593-600. Epub 2007 Apr 1.
PubMed 17493645
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Tordoff MG, Bachmanov AA, Reed DR. Forty mouse strain survey of water and sodium intake. Physiol Behav. 2007 Aug 15;91(5):620-31. Epub 2007 Apr 1.
PubMed 17490693
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Tordoff MG, Bachmanov AA, Reed DR. Forty mouse strain survey of voluntary calcium intake, blood calcium, and bone mineral content. Physiol Behav. 2007 Aug 15;91(5):632-43. Epub 2007 Apr 1.
PubMed 17493644
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Vulpe1
Data
Protocol
McLachlan S, Vulpe CD Basal liver mineral levels and iron homeostasis in 18 diverse mouse strains
McLachlan S, Lee SM, Steele TM, Hawthorne PL, Zapala MA, Eskin E, Schork NJ, Anderson GJ, Vulpe CD. In silico QTL mapping of basal liver iron levels in inbred mouse strains. Physiol Genomics. 2011 Feb 11;43(3):136-47. Epub 2010 Nov 9.
PubMed 21062905
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Yuan3
Data
Protocol
Yuan R, Korstanje R Aging study: Blood chemistry for 32 inbred strains of mice
Sinke AP, Caputo C, Tsaih SW, Yuan R, Ren D, Deen PM, Korstanje R. Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation. Physiol Genomics. 2011 Mar 16;43(5):265-70. Epub 2010 Dec 21.
PubMed 21177381
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