Phenotype >
| Project data set: Paigen2
(2002)
|
| Project |
Diet effects on plasma lipids and susceptibility to atherosclerosis in 43 inbred strains of mice on high-fat atherogenic diet (under pathogen-free conditions)
|
| Afilliation | Heart, Lung, and Blood Center |
| Investigators |
Beverly Paigen
The Jackson Laboratory Bar Harbor, ME
Karen L Svenson
The Jackson Laboratory Bar Harbor, ME
Luanne L Peters
The Jackson Laboratory Bar Harbor, ME
|
| Web site |
Investigator's lab
|
| Contact |
Beverly Paigen bev.paigen@jax.org
|
Other
participants |
Von Smith R |
Introductory
description |
Animals were evaluated at baseline and then again after 17 wks on
high fat (15% fat) diet.
| | Study design |
Study design:
baseline and intervention;
1 cohort.
43 strains tested
Test age:
7-9wks, 24-27wks
|
| Availability |
Strain survey data and protocol available – click here to view
|
| Changelog |
There have been
4 updates or corrections
to the data set since MPD release
in
May 2003
|
Notes and
funding |
Funding provided by NIH HL66611
In fulfillment of NIH requirements that all information is made promptly and freely
available to the research community, data are deposited in the MPD when complete.
|
Reference |
Svenson KL, Von Smith R, Magnani PA, Suetin HR, Paigen B, Naggert JK, Li R, Churchill GA, Peters LL. Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations.
J Appl Physiol. 2007 Jun;102(6):2369-78. Epub 2007 Feb 22.
PubMed 17317875
MGI
|
Related papers |
Chen Y, Rollins J, Paigen B, Wang X. Genetic and genomic insights into the molecular basis of atherosclerosis.
Cell Metab. 2007 Sep;6(3):164-79.
PubMed 17767904
MGI
Leduc MS, Hageman RS, Verdugo RA, Tsaih SW, Walsh K, Churchill GA, Paigen B. Integration of QTL and bioinformatic tools to identify candidate genes for triglycerides in mice.
J Lipid Res. 2011 Sep;52(9):1672-82. Epub 2011 May 26.
PubMed 21622629
MGI
FullText
Srivastava U, Paigen BJ, Korstanje R. Differences in health status affect susceptibility and mapping of genetic Loci for atherosclerosis (Fatty streak) in inbred mice.
Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2380-6. Epub 2012 Jul 26.
PubMed 22837474
MGI
Svenson KL, Bogue MA, Peters LL. Genetic Models in Applied Physiology: Invited Review: Identifying new mouse models of cardiovascular disease: a review of high-throughput screens of mutagenized and inbred strains.
J Appl Physiol. 2003 Apr;94(4):1650-9.
PubMed 12626479
MGI
Wittenburg H, Lyons MA, Li R, Kurtz U, Wang X, Mössner J, Churchill GA, Carey MC, Paigen B. QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains.
J Lipid Res. 2006 Aug;47(8):1780-90. Epub 2006 May 9.
PubMed 16685081
MGI
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