| Project |
Acute functional tolerance to ethanol in 74 ILSXISS recombinant inbred strains of mice
|
| Investigators |
Beth Bennett
University of Colorado Denver School of Medicine Aurora, CO
Thomas E Johnson
University of Colorado Boulder, CO
|
| Web site |
Investigator's lab
|
| Contact |
Beth Bennett Beth.Bennett@ucdenver.edu
|
Other
participants |
Downing C, Carosone-Link P, Ponicsan H, Ruf C |
Introductory
description |
Alcohol sensitivity and acute alcohol tolerance were studied in a single cohort of mice using a test of ataxia: loss and regain of balance on a stationary wooden dowel upon exposure to two doses of EtOH within the same testing session.
|
| Study design |
Study design:
all mice subjected to an intervention;
1 cohort.
74 strains tested
Test age:
8-14wks
|
| Availability |
Strain survey data and protocol available – click here to view
|
| Changelog |
There have been no updates or corrections
to the data set since MPD release
in
Jul 2011
|
Notes and
funding |
Funding provided by NIH AA11984, AA08940 |
Reference |
Bennett B, Downing C, Carosone-Link P, Ponicsan H, Ruf C, Johnson TE. Quantitative trait locus mapping for acute functional tolerance to ethanol in the L x S recombinant inbred panel.
Alcohol Clin Exp Res. 2007 Feb;31(2):200-8.
PubMed 17250610
MGI
|
Related papers |
Owens JC, Stallings MC, Johnson TE. Genetic analysis of low-dose ethanol-induced activation (LDA) in inbred long sleep (ILS) and inbred short sleep (ISS) mice.
Behav Genet. 2002 May;32(3):163-71.
PubMed 12141778
MGI
Williams RW, Bennett B, Lu L, Gu J, DeFries JC, Carosone-Link PJ, Rikke BA, Belknap JK, Johnson TE. Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis.
Mamm Genome. 2004 Aug;15(8):637-47.
PubMed 15457343
MGI
|
