||Drug study: Imipramine effects in 12 inbred strains of mice measured by tail suspension, light-dark transition, and open field tests
Howard K Gershenfeld
University of Texas - Southwestern Dallas, TX
Howard K Gershenfeld Howard.Gershenfeld@UTSouthwestern.edu
An investigation of stress response and sensitivity to
antidepressant/anxiolytic effect of imipramine.
Animals were evaluated for "stress reactivity" using the tail suspension test.
They were measured for "exploratory fear" behavior using the light-dark transition and open field tests.
Imipramine was administered to alleviate stress arising from
immobility. There were two cohorts tested at baseline and again following i.p. injection:
1) controls with saline i.p.; 2) treated with imipramine 30 mg/kg body weight i.p.
control vs. intervention;
12 strains tested
Strain survey data and protocol available – click here to view
There have been no updates or corrections
to the data set since MPD release
Funding provided by NIH MH58882; National Association for
Research on Schizophrenia and Depression Young Investigators Award; Southwestern Medical Foundation; KZA Hope Fund |
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