| Project |
Drug study: Imipramine effects in 12 inbred strains of mice measured by tail suspension, light-dark transition, and open field tests
|
| Investigators |
Howard K Gershenfeld
University of Texas - Southwestern Dallas, TX
|
| Contact |
Howard K Gershenfeld Howard.Gershenfeld@UTSouthwestern.edu
|
Other
participants |
Liu X |
Introductory
description |
An investigation of stress response and sensitivity to
antidepressant/anxiolytic effect of imipramine.
Animals were evaluated for "stress reactivity" using the tail suspension test.
They were measured for "exploratory fear" behavior using the light-dark transition and open field tests.
Imipramine was administered to alleviate stress arising from
immobility. There were two cohorts tested at baseline and again following i.p. injection:
1) controls with saline i.p.; 2) treated with imipramine 30 mg/kg body weight i.p.
|
| Study design |
Study design:
control vs. intervention;
2 cohorts.
12 strains tested
only
Test age:
5-10wks
|
| Availability |
Strain survey data and protocol available – click here to view
|
| Changelog |
There have been no updates or corrections
to the data set since MPD release
in
Jul 2007
|
Notes and
funding |
Funding provided by NIH MH58882; National Association for
Research on Schizophrenia and Depression Young Investigators Award; Southwestern Medical Foundation; KZA Hope Fund |
Reference |
Liu X, Gershenfeld HK. An exploratory factor analysis of the Tail Suspension Test in 12 inbred strains of mice and an F2 intercross.
Brain Res Bull. 2003 May 15; 60(3): 223-31.
PubMed 12754084
MGI
Liu X, Gershenfeld HK. Genetic differences in the tail-suspension test and its relationship to imipramine response among 11 inbred strains of mice.
Biol Psychiatry. 2001 Apr 1;49(7):575-81.
PubMed 11297714
MGI
|
Related papers |
Bai F, Li X, Clay M, Lindstrom T, Skolnick P. Intra- and interstrain differences in models of 'behavioral despair'.
Pharmacol Biochem Behav. 2001 Oct-Nov;70(2-3):187-92.
PubMed 11701187
MGI
Liu X, Peprah D, Gershenfeld HK. Tail-suspension induced hyperthermia: a new measure of stress reactivity.
J Psychiatr Res. 2003 May-Jun; 37(3): 249-59.
PubMed 12650744
MGI
Liu X, Stancliffe D, Lee S, Mathur S, Gershenfeld HK. Genetic dissection of the tail suspension test: a mouse model of stress vulnerability and antidepressant response.
Biol Psychiatry. 2007 Jul 1;62(1):81-91. Epub 2006 Nov 27.
PubMed 17125744
MGI
Yoshikawa T, Watanabe A, Ishitsuka Y, Nakaya A, Nakatani N. Identification of multiple genetic loci linked to the propensity for 'behavioral despair' in mice.
Genome Res. 2002 Mar;12(3):357-66.
PubMed 11875023
MGI
|
