Phenotype >
| Project data set: Johnson1
(2000)
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| Project |
Assessment of age-dependent hearing loss in 51 inbred strains of mice
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| Investigators |
Kenneth R Johnson
The Jackson Laboratory Bar Harbor, ME
Lawrence C Erway
University of Cincinnati Cincinnati, OH
Qing Yin Zheng
Case Western Reserve University School of Medicine Cleveland, OH
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| Web site |
Investigator's lab
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| Contact |
Kenneth R Johnson kjr@jax.org
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Introductory
description |
Four ABR threshold measurements were taken per mouse, in response to four different audible sounds.
The first measurement was for a click;
the second for an 8kHz pip; the third for a 16kHz pip; the fourth for a 32kHz pip.
The results are presented here broken down by mouse age.
Early onset of hearing impairment occurs at age < 13 weeks.
Later onset of hearing impairment occurs at age ≥ 13 weeks.
| | Study design |
Study design:
baseline survey;
2 cohorts.
51 strains tested
Test age:
3-12wks and 15-72wks
|
| Availability |
Strain survey data and protocol available – click here to view
|
| Changelog |
There have been
2 updates or corrections
to the data set since MPD release
in
Feb 2001
|
Notes and
funding |
Funding provided by NIH DC62108, CA34196
|
Reference |
Zheng QY, Johnson KR, Erway LC. Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses.
Hear Res. 1999 Apr;130(1-2):94-107.
PubMed 10320101
MGI
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Related papers |
Johnson KR, Gagnon LH, Longo-Guess C, Kane KL. Association of a citrate synthase missense mutation with age-related hearing loss in A/J mice.
Neurobiol Aging. 2012 Aug;33(8):1720-9. doi: 10.1016/j.neurobiolaging.2011.05.009. Epub 2011 Jul 30.
PubMed 21803452
MGI
FullText
Johnson KR, Longo-Guess C, Gagnon LH, Yu H, Zheng QY. A locus on distal chromosome 11 (ahl8) and its interaction with Cdh23 ahl underlie the early onset, age-related hearing loss of DBA/2J mice.
Genomics. 2008 Oct;92(4):219-25. Epub 2008 Aug 15.
PubMed 18662770
MGI
Johnson KR, Zheng QY, Noben-Trauth K. Strain background effects and genetic modifiers of hearing in mice.
Brain Res. 2006 May 26;1091(1):79-88. Epub 2006 Mar 31.
PubMed 16579977
MGI
Jones SM, Jones TA, Johnson KR, Yu H, Erway LC, Zheng QY. A comparison of vestibular and auditory phenotypes in inbred mouse strains.
Brain Res. 2006 May 26;1091(1):40-6. Epub 2006 Feb 24.
PubMed 16499890
MGI
Keithley EM, Canto C, Zheng QY, Fischel-Ghodsian N, Johnson KR. Age-related hearing loss and the ahl locus in mice.
Hear Res. 2004 Feb;188(1-2):21-8.
PubMed 14759567
MGI
Noben-Trauth K, Johnson KR. Inheritance patterns of progressive hearing loss in laboratory strains of mice.
Brain Res. 2009 Jun 24;1277:42-5Epub 2009 Feb 21.
PubMed 19236853
MGI
FullText
Zheng QY, Ding D, Yu H, Salvi RJ, Johnson KR. A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A/J mice.
Neurobiol Aging. 2009 Oct;30(10):1693-705. Epub 2008 Feb 14.
PubMed 18280008
MGI
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