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Data set / project: Sugiyama2   (2001)

Project Blood pressure in males of reciprocal backcrosses between C57BL/6J (salt-sensitive) and A/J (non-salt-sensitive)

Sugiyama2     MPD:119     2001     QTLA: Sugiyama_2001

AfilliationChurchill Group QTL Archive
Investigators Fimihiro Sugiyama     University of Tsukuba   Tsukuba   JAPAN
Gary A Churchill     The Jackson Laboratory   Bar Harbor, ME
Contact Gary A Churchill
gary.churchill@jax.org
Other participants Sen S
  To investigate the genetic control of salt-induced hypertension, a QTL analysis was performed on male mice from a reciprocal backcross between the salt-sensitive C57BL/6J and the normotensive A/J inbred mouse strains. At 8 wks of age, progeny were provided with drinking water containing 1% NaCl for 2 wks. Blood pressure was measured using the tail cuff method. See Sugiyama et al, 2001 (below) for procedural details and sampling methods.
Availability
 Available download files:
Excel file with descriptions and data: • Data_Description_B6xA_BC_Sugiyama2001.xlsx
CSV files • Sugiyama2001_B6xA_BC_B37_Data.csv
Readme / text files: • readme_Sugiyama2001.txt
Progenitors: A/J   C57BL/6J         Cross type: Reciprocal backcross
Population size: 0     250    


Studied phenotypes
BP_salt   systolic blood pressure [mmHg] age 10wks sodium chloride 1%soln 2wks
Ontology term mappings

Phenotyping methodologies utilized:   • tail cuff    



Genomic features
MGI-curated genomic features associated with this data set.   This curation is ongoing.
Chr 1156774467-156774646 (size 179 bp) Bpq2 MGI info MPD info
Chr 459402240-59402381 (size 141 bp) Bpq3 MGI info MPD info
Chr 5138556974-138557193 (size 219 bp) Bpq4 MGI info MPD info
Chr 6146428986-146429238 (size 252 bp) Bpq5 MGI info MPD info
Chr 1545419250-45419343 (size 93 bp) Bpq6 MGI info MPD info
(syntenic) Bpq1 MGI info


Notes and
funding
Funding provided by NIH HL55001, CA34196; Japanese Ministry of Education, Science, Sport, and Culture
Changelog No updates or corrections have been posted since initial release in Jan 2008
Relocated to MPD from http://qtlarchive.org in Feb 2015.

Reference
Sen S, Churchill GA. A statistical framework for quantitative trait mapping. Genetics. 2001 Sep;159(1):371-87.     PubMed 11560912     MGI

Sugiyama F, Churchill GA, Higgins DC, Johns C, Makaritsis KP, Gavras H, Paigen B. Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics. 2001 Jan 1;71(1):70-7.     PubMed 11161799     MGI

 




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