| Project |
Drug study: ENU-induced tumorigenesis in 20 inbred strains of mice
|
| Investigators |
Timothy A Graubert
Washington University School of Medicine St. Louis, MO
James W Watters
Washington University School of Medicine St. Louis, MO
Howard L McLeod
University of North Carolina Chapel Hill, NC
|
| Web site |
Investigator's lab
|
| Contact |
Timothy A Graubert graubert@medicine.wustl.edu
|
Other
participants |
Fenske TS |
Introductory
description |
An investigation of secondary malignancies and whether certain susceptibilities are genetically predetermined.
Animals were evaluated for baseline hematology. Some animals were treated with
N-nitroso-N-ethylurea (ENU)
and then evaluated for tumor burden in the blood, lungs, and gastrointestinal system.
There were two cohorts: 1) controls;
2) treated with 100 mg/kg body weight ENU i.p.
|
| Study design |
Study design:
control vs. intervention;
2 cohorts.
20 strains tested
Test age:
9wks; 3-16mo
|
| Availability |
Strain survey data and protocol available – click here to view
|
| Changelog |
There have been
2 updates or corrections
to the data set since MPD release
in
Jul 2008
|
Notes and
funding |
Funding provided by NIH GM063340
Generous funds from AstraZeneca were used to defray the
cost of mice through the Mouse Phenome Project
Collaborations Program.
|
Reference |
Fenske TS, McMahon C, Edwin D, Jarvis JC, Cheverud JM, Minn M, Mathews V, Bogue MA, Province MA, McLeod HL, Graubert TA. Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice.
Cancer Res. 2006 May 15;66(10):5029-38.
PubMed 16707424
MGI
|
Related papers |
Watters JW, Kloss EF, Link DC, Graubert TA, McLeod HL. A mouse-based strategy for cyclophosphamide pharmacogenomic discovery.
J Appl Physiol. 2003 Oct;95(4):1352-60.
PubMed 12970373
MGI
Watters JW, McLeod HL. Using genome-wide mapping in the mouse to identify genes that influence drug response.
Trends Pharmacol Sci. 2003 Feb;24(2):55-8.
PubMed 12559764
MGI
|
