Farmer MA, Sundberg JP, Bristol IJ, Churchill GA, Li R, Elson CO, Leiter EH. A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice.
Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13820-5. Epub 2001 Nov 13.
Investigators |
M A Farmer Gary A Churchill The Jackson Laboratory, Bar Harbor, ME |
Participants | Sundberg JP, Bristol IJ, Li R, Elson CO, Leiter EH |
Contact | Gary A Churchill gary.churchill@jax.org |
Affiliated Center | QTL Archive |
Acknowledgements | Grant: This work was supported by National Institutes of Health Grant PPG-44240.Institutional shared ser vices (The Jackson Laborator y) were supported by National Cancer Institute Cancer Center Support Grant CA-34196. |
QTL Archive data set | |
MPD identifiers | Farmer1 MPD:113 |
No updates/corrections. Initial release date: 05/2011. |
Progenitor strains | B6.Il10-/- C3H.Il10-/- |
Cross direction notation | (C3H x B6) F1 x (C3H x B6) F1; (B6 x C3H) F1 x (B6 x C3H) F1 |
Cross type | F2 reciprocal intercross |
Population size | 201 ♀ 210 ♂ |
Age | 6wks |
Data set | Procedure / Protocol | Treatment | Phenotype Measure / Variable (click to view) | Panel | No. of Strains | Sex | Age | Sample Size (Avg) | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
histopathology | (none) | severity of lesions in cecum [score] CecumSeverity 11301 | QTL population | both | N=206 | |||||||
histopathology | (none) | hyperplasia of cecum [score] CecumHyperplasia 11302 | QTL population | both | N=206 | |||||||
histopathology | (none) | ulceration in cecum [score] CecumUlceration 11303 | QTL population | both | N=206 | |||||||
histopathology | (none) | percentage of cecum damaged area [%] CecumDA 11304 | QTL population | both | N=206 | |||||||
histopathology | (none) | sum of cecum severity, hyperplasia, ulceration and damaged area scores [score] CecumTotalScore 11305 | QTL population | both | N=206 | |||||||
histopathology | (none) | percentage of proximal colon damaged area [%] ProxDA 11306 | QTL population | both | N=206 | |||||||
histopathology | (none) | severity of lesions in proximal colon [score] ProxSeverity 11307 | QTL population | both | N=206 | |||||||
histopathology | (none) | hyperplasia of proximal colon [score] ProxHyperplasia 11308 | QTL population | both | N=206 | |||||||
histopathology | (none) | ulceration in proximal colon [score] ProxUlceration 11309 | QTL population | both | N=206 | |||||||
histopathology | (none) | percentage of damaged area in mid colon [%] MidDA 11310 | QTL population | both | N=206 | |||||||
histopathology | (none) | severity of lesions in mid colon [score] MidSeverity 11311 | QTL population | both | N=206 | |||||||
histopathology | (none) | hyperplasia of mid colon [score] MidHyperplasia 11312 | QTL population | both | N=206 | |||||||
histopathology | (none) | ulcers and crypts frequency score [score] MidUlceration 11313 | QTL population | both | N=206 | |||||||
histopathology | (none) | percentage of damaged area in distal colon [%] DistalDA 11314 | QTL population | both | N=206 | |||||||
histopathology | (none) | severity of lesions in distal colon [score] DistalSeverity 11315 | QTL population | both | N=206 | |||||||
histopathology | (none) | hyperplasia of distal colon [score] DistalHyperplasia 11316 | QTL population | both | N=206 | |||||||
histopathology | (none) | ulceration in distal colon [score] DistalUlceration 11317 | QTL population | both | N=206 | |||||||
histopathology | (none) | proximal colon score [score] ProximalColon 11318 | QTL population | both | N=206 | |||||||
histopathology | (none) | middle colon score [score] MiddleColon 11319 | QTL population | both | N=206 | |||||||
histopathology | (none) | distal colon score [score] DistalColon 11320 | QTL population | both | N=206 | |||||||
histopathology | (none) | total score [score] ColonTotalScore 11321 | QTL population | both | N=206 | |||||||
body weight | (none) | body weight [g] Weight 11322 | QTL population | both | N=206 | |||||||
organ weights | (none) | spleen weight [g] SpleenWeight 11323 | QTL population | both | N=206 | |||||||
organ weights | (none) | spleen/body weight ratio [%] SplBW 11324 | QTL population | both | N=206 | |||||||
organ weights | (none) | mesenteric lymph node (MLN) weight [g] MLNWeight 11325 | QTL population | both | N=206 | |||||||
organ weights | (none) | MLN/body weight ratio [%] MLNBW 11326 | QTL population | both | N=206 | |||||||
health assessment | (none) | diarrhea grade [score] Diarrhea 11327 | QTL population | both | N=206 | |||||||
microscopy | (none) | blood in feces [score] Color 11328 | QTL population | both | N=206 | |||||||
hormone quantification | (none) | lgG2a antibodies against escherichia coli membrane antigens [ng/ml] IgG2aantiECM 11329 | QTL population | both | N=206 | |||||||
hormone quantification | (none) | levels of total lgG reactivity against escherichia coli membrane (ECM) antigens [ng/ml] IgGantiECM 11330 | QTL population | both | N=206 | |||||||
hormone quantification | (none) | secretory IgA in collected blood [ng/ml] IgA 11331 | QTL population | both | N=206 | |||||||
hormone quantification | (none) | levels of IgA secreted in feces [ng/ml] IgAfeces 11332 | QTL population | both | N=206 | |||||||
immune cell quantification | (none) | percentage of Interleukin 12 in collected blood [%] IL12 11333 | QTL population | both | N=206 | |||||||
immune cell quantification | (none) | percentage of viable CD4+ T cells in 150 µl collected blood [%] CD4 11334 | QTL population | both | N=206 | |||||||
immune cell quantification | (none) | percentage of viable CD8+ T cells in 150 µl collected blood [%] CD8 11335 | QTL population | both | N=206 | |||||||
immune cell quantification | (none) | percentage of viable B220+ B cells in 150 µl collected blood [%] B220 11336 | QTL population | both | N=206 | |||||||
immune cell quantification | (none) | percentage of viable IgM+ B cells in 150 µl collected blood [%] lgM 11337 | QTL population | both | N=206 | |||||||
immune cell quantification | (none) | percentage of macrophages in 150 µl collected blood [%] Macrophages 11338 | QTL population | both | N=206 | |||||||
immune cell quantification | (none) | percentage of viable granulocytes in 150 µl collected blood [%] Granulocytes 11339 | QTL population | both | N=206 | |||||||