Home       About             Help       Projects > Crabbe2 > Crabbe2 animal documentation Crabbe JC, Gallaher EJ, Belknap JK with Cross SJ Drug study: Effects of diazepam on activity, motor coordination, and body temperature, in 15 inbred strains of mice A investigation of the pharmacogenetic components and behavioral sensitivity to diazepam. Animals were evaluated at baseline and following diazepam administration (doses of 2, 4, 8, 16, and 20 mg/kg body weight i.p.) in the following areas: multi-system analysis of activity and motor function, coordination and balance, drug metabolism, and thermal regulation. Crabbe2 project data page       Protocol

Acclimation & testing periods Vendor Mice were obtained at 5 wks of age from The Jackson Laboratory JAX® (Bar Harbor, ME) Acclimation duration at test facility 1 wks in conventional, non-barrier facility at Oregon Health and Science University, Portland Oregon, USA Age at testing 6-7 wks of age Feed Purina 5001 bought locally; ad libitum. Water Tap; ad libitum Housing 4 mice per cage (Thoren clear polypropylene 28 x 18 x 13 cm) with filter tops for all strains Bedding 1/4" Bed-o-cob Photoperiod 12 h on (0600 h) 12 h off Temperature 21 +/- 2.0 C Health status Mice were reported in excellent health

Compiled and reviewed by MPD staff in conjunction with contributing investigators. Send comments or suggestions for this page

Hosted by:

Contact us About MPD Also at JAX

Units Changelog Downloads

Citing Funding Terms of Use