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Project data set: Wahlsten1   (2003)

Project Survey of motor activity, behavior, and forebrain morphometry in 21 inbred strains of mice across two laboratories

Study design: baseline survey; 1 cohort.
21 strains tested     female male     Test age: 9, 12 wks
Sample sizes are 9.3 on average. ... Caution, some N ≤ 2 are present  [details]

Investigators Wahlsten D, Crabbe JC     [Project details, papers, citing]

Protocol View phenotyping protocol and methods

Wahlsten1
measurements



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behavior — anxiety         elevated plus maze  
Wahlsten1
time spent in two closed arms   [s] 21 strains   age 9wks
  Inbred
Wahlsten1
number fecal boli, 5 min trial   [n] 21 strains   age 9wks
  Inbred
Wahlsten1
percent time spent in open arms vs closed   [%] 21 strains   age 9wks
  Inbred
 
behavior — anxiety         open field test  
Wahlsten1
percent of 5 min spent within 10 cm of wall   [%] 21 strains   age 9wks
  Inbred
Wahlsten1
number of fecal boli, within 5 min trial   [n] 21 strains   age 9wks
  Inbred
 
behavior — exploratory         elevated plus maze  
Wahlsten1
average distance traveled in 1 min   [cm] 21 strains   age 9wks
  Inbred
Wahlsten1
time spent in zones        
• center hub   • two open arms 
21 strains   age 9wks
  Inbred
 
behavior — exploratory         open field test  
Wahlsten1
average distance traveled in 1 min   [cm] 21 strains   age 9wks
  Inbred
 
behavior — locomotor activity         elevated plus maze  
Wahlsten1
distance traveled [cm]        
during minute: • 1  • 2  • 3  • 4  • 5      time comparison  
21 strains   age 9wks
  Inbred
Wahlsten1
movement        
• % time moving   • speed when moving 
21 strains   age 9wks
  Inbred
 
behavior — locomotor activity         open field test  
Wahlsten1
distance traveled [cm]        
during minute: • 1  • 2  • 3  • 4  • 5      time comparison  
21 strains   age 9wks
  Inbred
Wahlsten1
average speed over 5 min trial   [cm/sec] 21 strains   age 9wks
  Inbred
 
brain — morphology — size         histopathology  
Wahlsten1
corpus callosum        
• length at mid-sagittal plane   • cross-sectional area at midplane   • index 
21 strains   age 12wks
  Inbred
Wahlsten1
hippocampus        
• length at mid-sagittal plane   • cross-sectional area at midplane   • index 
21 strains   age 12wks
  Inbred
Wahlsten1
anterior commissure        
• length at mid-sagittal plane   • cross-sectional area at midplane   • index 
21 strains   age 12wks
  Inbred
 
brain — morphology — weight         scales  
Wahlsten1
brain weight (after fixation and trimming)        
• weight   • as percent of body weight 
21 strains   age 12wks
  Inbred


local experiment parameter  
Wahlsten1
body weight, end of testing   [g] 21 strains   age 12wks
  Inbred
Wahlsten1
tissue quality; 0=no faults, 1=one or more faults   [score] 21 strains   age 12wks
  Inbred


  
Reference
Wahlsten D, Bachmanov A, Finn DA, Crabbe JC. Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16364-9. Epub 2006 Oct 19.     PubMed 17053075     MGI

Wahlsten D, Metten P, Crabbe JC. Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Res. 2003 May 2;971(1):47-54.     PubMed 12691836     MGI

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Mice

Strain and animal info

Citing

Cite this MPD data set

Changelog

One update or correction was posted since MPD release in Jul 2003  

Note

This study was conducted on the same set of mice rated for wildness and ease of handling (Wahlsten2).

Wahlsten1 data were measured at two different sites, Edmonton and Portland. The data were pooled to compute strain means for the above MPD measurements.

Comparability across testing sites
MPD has computed correlations to look at comparability / reproducability of results across the two testing sites: Wahlsten1_sitecorrs.csv
Strain/sex averages were correlated to compare Edmonton vs. Portland for brain morphology and behavior components (the latter was added March 2014). Pearson and Spearman statistics are available as well as pvalue on the Pearson.

Note, low sample sizes (N=2) are present for SPRET/EiJ males.

Note

Some measurements were derived by MPD staff,
based on supplied data. [View list]

Note

Some measurements are not eligible for all-MPD pheno vs. pheno
correlations due to data characteristics or semantics [View list]

Wahlsten1
downloads


Individual animal data
Table format (.csv)
All individual animal data, table format, one row per animal and one column per measurement.
Individual animal data
List format (.csv)
All numeric animal data values, one row per animal per measurement.
Strain means (.csv) Strain means with SD, N, other summary statistics. One row per strain / sex / measurement.
No supplemental data for this project. 

 See also MPD's general data download page for other options.





 




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