|Project data set: Paigen3 (2000)|
Diet effects on gallstone formation, liver pathology, plasma lipids, and pathogen-accelerated atherosclerosis in 8 obesity mutant mouse strains
All animals were fed a high-fat (15% fat) diet for 8 wks. Blood chemistry and cholesterol were measured.
After sac, a pathology review of livers and gallbladders was conducted.
all mice subjected to an intervention;
8 strains tested
Paigen B, Bouchard G, Carey MC
Heart, Lung, and Blood Center
|Part of a series:||
• Inbred strains ... see Paigen1|
• Obesity mutant strains ... this project ... Paigen3
View phenotyping protocol and methods
Number of mice tested per strain, for each measurement
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There have been
4 updates or corrections
to the data set since MPD release
Bouchard G, Johnson D, Carver T, Paigen B, Carey MC. Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk.
J Lipid Res. 2002 Jul;43(7):1105-13.
Strain and animal info
Mice were housed in a non-barrier facility during the acclimation and
testing periods. Three pathogens were detected during this time:
Pneumocystis, Pasturella, and Helicobacter. Pathogen-accelerated
atherosclerosis was observed in these studies.
These results are in
contrast to a similar study conducted in a pathogen-free facility
Similar data are available for 43 inbred strains also tested by these
(identical C57BL/6J and C57BLKS/J data are present in both data sets).
This project includes a collection of browsable
liver pathology images.
Please note: Low sample sizes (N < 5) are present.
Some measurements were derived by MPD staff,
based on supplied data. [View list]
Some measurements are not eligible for all-MPD pheno vs. pheno
correlations due to data characteristics or semantics
See also the MPD download center for more general data download options.