blood — clinical chemistry         metabolic panel   Paigen3 alanine aminotransferase (plasma ALT)   [IU/L]   high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants Paigen3 bile salts (plasma)   [µmol/L]   high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants   blood — lipids         lipid profile   Paigen3 HDL cholesterol (plasma)   high-fat diet   8wks       • amount  • % of total plasma cholesterol  8 strains   age 15-19wks   obesity mutants Paigen3 plasma cholesterol not in the HDL fraction   [mg/dL]   high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants Paigen3 total cholesterol (plasma)   [mg/dL]   high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants   body weight         scales   Paigen3 body weight [g]     baseline and  high-fat diet 8wks       • start   • after 8wks on diet   • Δchange    • comparison   8 strains   age 7-11wks                 at baseline   obesity mutants   cardiovascular — atherosclerosis         histopathology   Paigen3 fatty streak aortic lesion size   [µm2]   high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants   gallbladder — pathology and gallstones         gravimetry   Paigen3 gallbladder volume   [µL]   high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants   gallbladder — pathology and gallstones         histopathology   Paigen3 gallbladder pathology (0-4) [score]   high-fat diet   8wks         • mucin    • arc    • filaments          liquid crystals:   • small    • aggregated    • fused    • comparison           cholesterol monohydrate crystals:   • all  8 strains   age 15-19wks   obesity mutants Paigen3 gallstones [n]   high-fat diet   8wks       • sandy  • true  • all  • presence score [0/1]    • comparison   8 strains   age 15-19wks   obesity mutants   liver — lipid homeostasis         lipid profile   Paigen3 hepatic cholesterol concentration [mg]   high-fat diet   8wks       • free  • esterified  • total   • free to esterified ratio  8 strains   age 15-19wks   obesity mutants   liver — pathology         histopathology   Paigen3 liver pathology (0-4) [score]   high-fat diet   8wks       • images  • microvacuoles  • macrovacuoles  • inflammation  8 strains   age 15-19wks   obesity mutants   liver — weight         scales   Paigen3 liver weight at sacrifice   [g]   high-fat diet   8wks 8 strains   age 15-19wks   obesity mutants local experiment parameter   Paigen3 age at start of diet   [d] 8 strains     obesity mutants

Number of mice tested per strain, for each measurement