MPD: Data set: Moy1

Moy SS, Nadler JJ, Young NB, Perez A, Holloway LP, Barbaro RP, Barbaro JR, Wilson LM, Threadgill DW, Lauder JM, Magnuson TR, Crawley JN. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res. 2007 Jan 10;176(1):4-20. Epub 2006 Sep 12. PubMed 16971002 FullText

Moy SS, Nadler JJ, Young NB, Nonneman RJ, Segall SK, Andrade GM, Crawley JN, Magnuson TR. Social approach and repetitive behavior in eleven inbred mouse strains. Behav Brain Res. 2008 Aug 5;191(1):118-29. Epub 2008 Mar 21. PubMed 18440079 FullText

Moy1 downloads
• Download Moy1 project data set animal data, as uploaded
• Download Moy1 animal data matrix with factor-related expansion applied as necessary
• Download Moy1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Moy1 measures:

Investigators	Sheryl S Moy University of North Carolina, Chapel Hill, NC Jacqueline N Crawley National Institute of Mental Health, Bethesda, MD Jean M Lauder University of North Carolina, Chapel Hill, NC Jessica J Nadler University of North Carolina, Chapel Hill, NC David W Threadgill Texas A&M University, College Station, TX Terry R Magnuson University of North Carolina, Chapel Hill, NC
Participants	Young NB, Perez A, Nonneman RJ
Contact	Terry R Magnuson trm4@med.unc.edu Lab web site
Acknowledgements	Funding provided by NIH MH66418, HD03110; NIMH Intramural Research Program Dr. Joseph Piven, Director of the Carolina Institute for Developmental Disabilities, provided valuable insights throughout the project.
Project type	Phenotype strain survey data set
MPD identifiers	Moy1 MPD:301
Data changelog	No updates/corrections. Initial release date: 02/2009.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

An investigation of autism-modelling possibilities. The hallmark signs of human autism include aberrant social interactions, deficits in communication, and rigid, repetitive behaviors. Autistic-like behaviors were assessed in mice using an automated 3-chambered social test apparatus. Shortly after a period of habituation to the social test box, mice were evaluated for sociability in the presence of an unfamiliar mouse,
Sociability test Mice were evaluated in a three-chambered choice task to determine preference for a novel social stimulus (an unfamiliar mouse) versus a novel object (an empty wire cage).

Preference for social novelty test Mice were evaluated in a three-chambered choice task to determine preference for a novel social stimulus (a newly-presented unfamiliar mouse) versus a former social stimulus (an already-investigated mouse). and then tested for social novelty preference by adding a second, less-familiar conspecific mouse to the apparatus.

Procedures conducted:

• three chamber assay

Sociability and preference for social novelty. Autism-relevant behaviors.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Moy1:1	Moy1	three chamber assay	(none)	time spent in chamber with stranger 1 (a novel mouse), 10 min test [s] DurSTR1_soc 30101	inbred	17	m	6-7wks	N=22

Moy1:2	Moy1	three chamber assay	(none)	time spent in chamber with empty cage (a novel object), 10 min test [s] DurOBJ_soc 30102	inbred	17	m	6-7wks	N=22

Moy1:3	Moy1	three chamber assay	(none)	time spent in center chamber, 10 min test [s] DurCEN_soc 30103	inbred	17	m	6-7wks	N=22

Moy1:4	Moy1	three chamber assay	(none)	time spent sniffing cage with stranger1 (a novel mouse), 10 min test [s] SnSTR1_soc 30104	inbred	17	m	6-7wks	N=22

Moy1:5	Moy1	three chamber assay	(none)	time spent sniffing empty cage (a novel object), 10 min test [s] SnOBJ_soc 30105	inbred	17	m	6-7wks	N=22

Moy1:6	Moy1	three chamber assay	(none)	number of entries into chamber with stranger1 (a novel mouse), 10 min test [n] EntSTR1_soc 30106	inbred	17	m	6-7wks	N=22

Moy1:7	Moy1	three chamber assay	(none)	number of entries into chamber with empty cage (a novel object), 10 min test [n] EntOBJ_soc 30107	inbred	17	m	6-7wks	N=22

Moy1:8	Moy1	three chamber assay	(none)	time spent in chamber with stranger1 (former novel mouse), 10 min test [s] DurSTR1_nov 30108	inbred	17	m	6-7wks	N=22

Moy1:9	Moy1	three chamber assay	(none)	time spent in chamber with stranger 2 (a second novel mouse), 10 min test [s] DurSTR2_nov 30109	inbred	17	m	6-7wks	N=22

Moy1:10	Moy1	three chamber assay	(none)	time spent in center chamber, 10 min test [s] DurCEN_nov 30110	inbred	17	m	6-7wks	N=22

Moy1:21	Moy1	three chamber assay	(none)	time spent sniffing cage with stranger1 (former novel mouse), 10 min test [s] SnSTR1_nov 30121	inbred	17	m	6-7wks	N=22

Moy1:22	Moy1	three chamber assay	(none)	time spent sniffing cage with novel stranger2 (a second novel mouse), 10 min test [s] SnSTR2_nov 30122	inbred	17	m	6-7wks	N=22

Moy1:23	Moy1	three chamber assay	(none)	number of entries into chamber with stranger1 (former novel mouse), 10 min test [n] EntSTR1_nov 30123	inbred	17	m	6-7wks	N=22

Moy1:24	Moy1	three chamber assay	(none)	number of entries into chamber with stranger2 (a second novel mouse), 10 min test [n] EntSTR2_nov 30124	inbred	17	m	6-7wks	N=22

Moy1: Investigation of autism-relevant behaviors in males of 17 inbred strains of mice (2008)