Phenotype >
| Project data set: Moy1 (2008) |
|
| | Project |
Investigation of autism-relevant behaviors in males of 17 inbred strains of mice
An investigation of autism-modelling possibilities.
The hallmark signs of human autism include aberrant social interactions,
deficits in communication, and rigid, repetitive behaviors.
Autistic-like behaviors were assessed in mice using an automated 3-chambered
social test apparatus. Shortly after a period of habituation to the social test
box, mice were evaluated for sociability in the presence of an unfamiliar mouse,
and then tested for social novelty preference by adding a second, less-familiar
conspecific mouse to the apparatus.
Study design:
baseline survey;
1 cohort.
17 strains tested
only
Test age:
6-7wks
|
| Investigators |
Moy SS, Crawley JN, Lauder JM, Nadler JJ, Threadgill DW, Magnuson TR
[Details, papers]
|
| Protocol |
View phenotyping protocol and methods
|
|
Moy1
measurements
|
Number of mice tested per strain, for each measurement
|
| | |
| Changelog |
There have been no updates or corrections
to the data set since MPD release
in
Feb 2009
|
| Reference |
Moy SS, Nadler JJ, Young NB, Nonneman RJ, Segall SK, Andrade GM, Crawley JN, Magnuson TR. Social approach and repetitive behavior in eleven inbred mouse strains.
Behav Brain Res. 2008 Aug 5;191(1):118-29. Epub 2008 Mar 21.
PubMed 18440079
MGI
FullText
Moy SS, Nadler JJ, Young NB, Perez A, Holloway LP, Barbaro RP, Barbaro JR, Wilson LM, Threadgill DW, Lauder JM, Magnuson TR, Crawley JN. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains.
Behav Brain Res. 2007 Jan 10;176(1):4-20. Epub 2006 Sep 12.
PubMed 16971002
MGI
FullText
Related papers
|
| Mice |
Strain and animal info
|
| Note |
Useful definitions:
Sociability test
Mice were evaluated in a three-chambered choice task to determine preference for a novel social stimulus
(an unfamiliar mouse) versus a novel object (an empty wire cage).
Preference for social novelty test
Mice were evaluated in a three-chambered choice task to determine preference for a novel social stimulus
(a newly-presented unfamiliar mouse) versus a former social stimulus (an already-investigated mouse).
|
Moy1
downloads
 |
See also the MPD download center for more general data download options.
|
|
| |
|
