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Data set: Mitchell1   (2010)

  Evaluating behavioral inhibition using a Go/No-go task in males of 15 inbred mouse strains
 

Study design: baseline survey   1 cohort.
15 strains tested     male only     Test age: 5-7wks
Sample sizes are 7.6 on average.  [details]

  Investigators: Mitchell SH     [More info... papers, citing, funding]

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Mitchell1
phenotype
measurements



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behavior — impulsivity — attentional set shifting         Go/No-go task  
Mitchell1
response        
• pre-cue rate  • Go hits  • No-go false alarms      comparison  
15 strains   age 5-7wks
  Inbred
Mitchell1
latency to respond [s]        
• Go cue  • No-go cue      comparison  
15 strains   age 5-7wks
  Inbred
Mitchell1
measures of efficiency and discrimination [ratio]        
• target specificity  • efficiency  • discrimination      comparison  
15 strains   age 5-7wks
  Inbred
 
behavior — locomotor activity         behavior monitoring system  
Mitchell1
ambulatory activity [cm]        
• day2 activity  • habituation 
15 strains   age 5-7wks
  Inbred


local experiment parameter  
Mitchell1
daily sucrose intake, two bottle choice test   [g/kg] 15 strains   age 5-7wks
  Inbred
Mitchell1
daily water intake, two bottle choice test   [mL/kg] 15 strains   age 5-7wks
  Inbred




MPD curation note: Responses to light or sound cues are highly dependant on visual or hearing ability. This information is critical to understanding and utilizing the data from this project. Several strains tested are visually impaired by 3 wks of age while others are hearing impaired (variable onset, depending on genetic background).
  • Vision: the following strains are homozygous for the retinal degeneration mutation, Pde6brd1 (phosphodiesterase 6B): C3H/HeJ, CBA/J, PL/J, SJL/J, SWR/J.
  • Hearing: the following strains are homozygous for the age-related hearing loss mutation, Cdh23ahl (cadherin 23, otocadherin): 129P3/J, C57L/J, C57BL/6J, C58/J, DBA/1J, DBA/2J.


No updates or corrections have been posted since initial release in Aug 2011
 
Gubner NR, Wilhelm CJ, Phillips TJ, Mitchell SH. Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains. Alcohol Clin Exp Res. 2010 Aug;34(8):1353-62. Epub 2010 May 14.     PubMed 20491731     MGI

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