appearance and coat color         SHIRPA   Lake2 body presentation [score]         • pelvic elevation  • tail elevation  • body position  • hindlimb splay  23 strains   age 8wks   B6.A consomic Lake2 color evaluation of plantar surface and forelimb digits during supine restraint (score 0-2)   [score] 23 strains   age 8wks   B6.A consomic   behavior — anxiety         SHIRPA   Lake2 frequency of behavioral displacement [n]         • defecation  • urination  23 strains   age 8wks   B6.A consomic Lake2 degree of behavioral inhibition or arousal [score]         • transfer arousal  • freezing  23 strains   age 8wks   B6.A consomic Lake2 frequency of behavioral displacement [n]         • defecation  • urination  23 strains   age 8wks   B6.A consomic   behavior — involuntary movement         SHIRPA   Lake2 constant trembling in view-jar (score 0-2)   [score] 23 strains   age 8wks   B6.A consomic Lake2 short sporadic twitches in view-jar (score 0-2)   [score] 23 strains   age 8wks   B6.A consomic   behavior — locomotor activity         SHIRPA   Lake2 spontaneous activity level in view-jar (score 0-3)   [score] 23 strains   age 8wks   B6.A consomic   behavior — wildness         SHIRPA   Lake2 aggressive behavior [score]         • provoked biting  • irritability  • aggression  • vocalization  23 strains   age 8wks   B6.A consomic   nervous system — autonomic function         SHIRPA   Lake2 autonomic function [score]         • palpebral closing  • piloerection  • airpuff startle reflex        • trunk curl  • hindlimb grasp  • lacrimal reflex  • salivary reflex  23 strains   age 8wks   B6.A consomic   nervous system — neuromuscular function         SHIRPA   Lake2 muscle function and fitness [score]         • gait  • positional passivity        • body tone  • limb tone  • abdominal tone  • response to tail suspension  • response to rotation  23 strains   age 8wks   B6.A consomic   nervous system — sensorimotor function         SHIRPA   Lake2 motor responses to sensory stimulus [score]         • touch escape  • visual placing  • pinna (ear) reflex  • corneal reflex        • hindfoot withdrawal reflex  • cross extensor reflex        • righting reflex  • catalepsy  • negative geotaxis  23 strains   age 8wks   B6.A consomic

Number of mice tested per strain, for each measurement