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Project data set: Lake1   (2005)

Project Multi-system analysis of mouse physiology, C57BL/6J-Chr#A/J/NaJ chromosome substitution panel

Animals were evaluated in these areas: hematology, blood chemistry, lung function, blood pressure and pulse, and electrocardiogram.

Study design: baseline survey; 1 cohort.
23 strains tested     female male     Test age: 7-11wks

Investigators Lake J, Donahue L, Davisson MT   [Details]

Part of a series: • physiology ... this project ... Lake1
• SHIRPA ... see Lake2
• behavior ... see Lake3
These projects characterize the B6.A consomic strain panel.

Protocol View phenotyping protocol and methods

Lake1
measurements



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For downloads and additional info see bottom of page...  


blood — clinical chemistry         metabolic panel  
Lake1
total bilirubin (plasma TBIL)   [mg/dL]
23 strains   age 8wks
  B6.A consomic
Lake1
aspartate aminotransferase (plasma AST)   [mg/dL]
23 strains   age 8wks
  B6.A consomic
Lake1
glucose (plasma GLU, 4h fast)   [mg/dL]
23 strains   age 8wks
  B6.A consomic
 
blood — hematology — cell counts         CBC  
Lake1
red blood cell count (RBC; per volume x 106)   [n/µL]
23 strains   age 7wks
  B6.A consomic
Lake1
reticulocyte count (Retic; units per volume x 109)   [n/L]
23 strains   age 7wks
  B6.A consomic
Lake1
reticulocyte differential (percent of total RBC)   [%]
23 strains   age 7wks
  B6.A consomic
Lake1
white blood cell count (WBC; per volume x 103)   [n/µL]
23 strains   age 7wks
  B6.A consomic
Lake1
basophil count (BASO; units per volume x 103)   [n/µL]
23 strains   age 7wks
  B6.A consomic
Lake1
basophil differential (percent of total WBC)   [%]
23 strains   age 7wks
  B6.A consomic
Lake1
eosinophil count (EOS; units per volume x 103)   [n/µL]
23 strains   age 7wks
  B6.A consomic
Lake1
eosinophil differential (percent of total WBC)   [%]
23 strains   age 7wks
  B6.A consomic
Lake1
lymphocyte count (LYMP; units per volume x 103)   [n/µL]
23 strains   age 7wks
  B6.A consomic
Lake1
lymphocyte differential (percent of total WBC)   [%]
23 strains   age 7wks
  B6.A consomic
Lake1
large unstained cells count (LUC; units per volume x 103)   [n/µL]
23 strains   age 7wks
  B6.A consomic
Lake1
large unstained cell differential (percent of total WBC)   [%]
23 strains   age 7wks
  B6.A consomic
Lake1
monocyte count (MONO; units per volume x 103)   [n/µL]
23 strains   age 7wks
  B6.A consomic
Lake1
monocyte differential (percent of total WBC)   [%]
23 strains   age 7wks
  B6.A consomic
Lake1
neutrophil count (NEUT; units per volume x 103)   [n/µL]
23 strains   age 7wks
  B6.A consomic
Lake1
neutrophil differential (percent of total WBC)   [%]
23 strains   age 7wks
  B6.A consomic
 
blood — hematology — hematocrit         CBC  
Lake1
hematocrit (HCT)   [%]
23 strains   age 7wks
  B6.A consomic
 
blood — hematology — hemoglobin         CBC  
Lake1
RBC corpuscular hemoglobin concentration mean (CHCM)   [g/dL]
23 strains   age 7wks
  B6.A consomic
Lake1
hemoglobin concentration distribution width (HDW)   [g/dL]
23 strains   age 7wks
  B6.A consomic
Lake1
mean RBC corpuscular hemoglobin content (MCH)   [pg]
23 strains   age 7wks
  B6.A consomic
Lake1
mean RBC corpuscular hemoglobin concentration (MCHC)   [g/dL]
23 strains   age 7wks
  B6.A consomic
Lake1
hemoglobin (HGB) [g/dL]  
      • measured  • calculated 
23 strains   age 7wks
  B6.A consomic
 
blood — hematology — platelets         CBC  
Lake1
platelet count (PLT; units per volume x 103)   [n/µL]
23 strains   age 7wks
  B6.A consomic
Lake1
mean platelet volume (MPV)   [fL]
23 strains   age 7wks
  B6.A consomic
 
blood — hematology — RBC parameters — cell distribution width RDW         CBC  
Lake1
RBC corpuscular distribution width (RDW)   [%]
23 strains   age 7wks
  B6.A consomic
 
blood — hematology — RBC parameters — cell volume MCV         CBC  
Lake1
mean RBC corpuscular volume (MCV)   [fL]
23 strains   age 7wks
  B6.A consomic
 
blood — lipids         lipid profile  
Lake1
HDL cholesterol (plasma HDL)   [mg/dL]
23 strains   age 8wks
  B6.A consomic
Lake1
total cholesterol (plasma CHOL)   [mg/dL]
23 strains   age 8wks
  B6.A consomic
Lake1
total fatty acids (plasma TFA)   [mg/dL]
23 strains   age 8wks
  B6.A consomic
Lake1
triglycerides (plasma TG)   [mg/dL]
23 strains   age 8wks
  B6.A consomic
 
cardiovascular — blood pressure         tail cuff  
Lake1
systolic blood pressure   [mmHg]
23 strains   age 10wks
  B6.A consomic
 
cardiovascular — ECG parameters — conscious         ECG  
Lake1
intervals [ms]  
      • RR   • PQ   • PR   • QRS   • QT   • QTc   • QT dispersion   • QTc dispersion 
23 strains   age 11wks
  B6.A consomic
 
cardiovascular — heart rate — conscious         ECG  
Lake1
heart rate [n/min]  
      • heart rate  • variability  • CV 
23 strains   age 11wks
  B6.A consomic
 
cardiovascular — heart rate — conscious         tail cuff  
Lake1
pulse rate [n/min]  
      • pulse rate  • variability 
23 strains   age 10wks
  B6.A consomic


local experiment parameter  
Lake1
systolic blood pressure variability across tests   [mmHg]
23 strains   age 10wks
  B6.A consomic



Number of mice tested per strain, for each measurement

  
Changelog There has been one update or correction to the data set since MPD release in Oct 2007  
Mice
Strain and animal info
Note
Please note: Low sample sizes (N < 5) are present. [View table]
Note
Some measurements were derived by MPD staff,
based on supplied data. [View list]
Note
Some measurements are not eligible for all-MPD pheno vs. pheno
correlations due to data characteristics or semantics [View list]

Lake1
downloads


Individual animal data
Table format (.csv)
Individual animal data in table format, with one row per animal and one column per measurement.
Individual animal data
List format (.csv)
Individual animal data organized as one row per animal / measurement reading.
Strain means (.csv) Strain means with SD, N, other summary statistics. One row per strain / sex / measurement.
No supplemental data for this project. 

 See also the MPD download center for more general data download options.





 




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