MPD: Data set: Jentsch1

Laughlin RE, Grant TL, Williams RW, Jentsch JD. Genetic dissection of behavioral flexibility: reversal learning in mice. Biol Psychiatry. 2011 Jun 1;69(11):1109-16. Epub 2011 Mar 9. PubMed 21392734 FullText

Jentsch1 downloads
• Download Jentsch1 project data set animal data, as uploaded
• Download Jentsch1 animal data matrix with factor-related expansion applied as necessary
• Download Jentsch1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Jentsch1 measures:

MP:0002063 abnormal learning/memory/conditioning
MP:0002803 abnormal operant conditioning behavior
MP:0010698 abnormal impulsive behavior control
VT:0002063 learning/memory/conditioning trait
VT:0010473 impulsivity behavior trait
VT:0010531 operant conditioning behavior trait

Investigators	J D Jentsch Binghamton University, Binghamton, NY Robert W Williams University of Tennessee, Memphis, TN
Participants	Laughlin RE, Grant TL
Contact	J D Jentsch jjentsch@binghamton.edu Lab web site
Part of a series:	• reversal learning, 51 BXD strains (this project) Jentsch1 • cocaine study, 4 BXD strains see Jentsch2
Acknowledgements	Funding provided by NIH DE019580, NS062410, NS048004, MH083270, MH083269, AA13499, AA13513, AA014425, DA021131
Project type	Phenotype strain survey data set
MPD identifiers	Jentsch1 MPD:403
Data changelog	No updates/corrections. Initial release date: 06/2012.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Behavioral inflexibility was measured using discrimination acquisition and subsequent operant reversal learning to assess heritable deficits in the inhibitory control over behavior.

Procedures conducted:

• operant conditioning chamber

Reversal learning test. Impulsivity, acquisition, reversal, conditioning. Performance and latency.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Jentsch1:1	Jentsch1	operant conditioning chamber	(none)	number of initiated trials per daily session, acquisition phase [n] acq_initiated_trials 40301	BXD w/par	53	m	17wks	N=3

Jentsch1:2	Jentsch1	operant conditioning chamber	(none)	number of trials with no choice made in first 30 s, acquisition phase [n] acq_no_choice 40302	BXD w/par	53	m	17wks	N=3

Jentsch1:3	Jentsch1	operant conditioning chamber	(none)	average number of anticipatory responses per trial, acquisition phase [n] acq_anticipatory 40303	BXD w/par	53	m	17wks	N=3

Jentsch1:4	Jentsch1	operant conditioning chamber	(none)	average latency to initiate trial, acquisition phase [s] acq_latency_trial 40304	BXD w/par	53	m	17wks	N=3

Jentsch1:5	Jentsch1	operant conditioning chamber	(none)	average latency to make correct choice, acquisition phase [s] acq_latency_correct 40305	BXD w/par	53	m	17wks	N=3

Jentsch1:6	Jentsch1	operant conditioning chamber	(none)	average latency to retrieve food reward, acquisition phase [s] acq_latency_reward 40306	BXD w/par	53	m	17wks	N=3

Jentsch1:7	Jentsch1	operant conditioning chamber	(none)	number of initiated trials per daily session, reversal phase [n] revers_init_trials 40307	BXD w/par	53	m	17wks	N=3

Jentsch1:8	Jentsch1	operant conditioning chamber	(none)	number of trials with no choice made in first 30 s, reversal phase [n] revers_no_choice 40308	BXD w/par	53	m	17wks	N=3

Jentsch1:9	Jentsch1	operant conditioning chamber	(none)	average number of anticipatory responses per trial, reversal phase [n] revers_anticipatory 40309	BXD w/par	53	m	17wks	N=3

Jentsch1:10	Jentsch1	operant conditioning chamber	(none)	average latency to initiate trial, reversal phase [s] revers_latency_trial 40310	BXD w/par	53	m	17wks	N=3

Jentsch1:11	Jentsch1	operant conditioning chamber	(none)	average latency to make correct choice, reversal phase [s] revers_latency_correct 40311	BXD w/par	53	m	17wks	N=3

Jentsch1:12	Jentsch1	operant conditioning chamber	(none)	average latency to retrieve food reward, reversal phase [s] revers_latency_reward 40312	BXD w/par	53	m	17wks	N=3

Jentsch1: Reversal learning in males of 51 BXD recombinant inbred strains of mice (2011)