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Project data set: Graubert1   (2006)

Project Drug study: ENU-induced tumorigenesis in 20 inbred strains of mice

An investigation of secondary malignancies and whether certain susceptibilities are genetically predetermined. Animals were evaluated for baseline hematology. Some animals were treated with N-nitroso-N-ethylurea (ENU) and then evaluated for tumor burden in the blood, lungs, and gastrointestinal system. There were two cohorts: 1) controls; 2) treated with 100 mg/kg body weight ENU i.p.

Study design: control vs. an intervention; 2 cohorts.
20 strains tested     female male     Test age: 9wks; 3-16mo
Sample sizes are 8.3 on average. ... Caution, some N ≤ 2 are present  [details]

Investigators Graubert TA, Watters JW, McLeod HL   [Details, papers]   [Citing]

Protocol View phenotyping protocol and methods

Graubert1
measurements



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blood — hematology — cell counts         CBC  
Graubert1
white blood cell count (WBC; per volume x 103)   [n/µL] 20 strains   age 9wks
  Inbred
Graubert1
lymphocyte count (LYMP; units per volume x 103)   [n/µL] 20 strains   age 9wks
  Inbred
Graubert1
lymphocyte differential (percent of total WBC)   [%] 20 strains   age 9wks
  Inbred
Graubert1
neutrophil count (NEUT; units per volume x 103)   [n/µL] 20 strains   age 9wks
  Inbred
Graubert1
neutrophil differential (percent of total WBC)   [%] 20 strains   age 9wks
  Inbred
 
blood — hematology — hemoglobin         CBC  
Graubert1
hemoglobin (HGB)   [g/dL] 20 strains   age 9wks
  Inbred
 
blood — hematology — platelets         CBC  
Graubert1
platelet count (PLT; units per volume x 103)   [n/µL] 20 strains   age 9wks
  Inbred
 
cancer — tumor growth — gastrointestinal tumors         histopathology  
Graubert1
gastrointestinal (GI) tumor frequency rate [score]     control and  ENU 100mg/kg      
• control  • ENU      comparison  
20 strains   age 3-16mo
  Inbred
 
cancer — tumor growth — hematopoetic tumors         histopathology  
Graubert1
lymphoid tumor frequency rate [score]     control and  ENU 100mg/kg      
• control  • ENU      comparison  
20 strains   age 3-16mo
  Inbred
Graubert1
myeloid tumor frequency rate [score]     control and  ENU 100mg/kg      
• control  • ENU      comparison  
20 strains   age 3-16mo
  Inbred
 
cancer — tumor growth — lung tumors         histopathology  
Graubert1
lung adenoma frequency rate [score]     control and  ENU 100mg/kg      
• control  • ENU      comparison  
20 strains   age 3-16mo
  Inbred
Graubert1
lung carcinoma frequency rate [score]     control and  ENU 100mg/kg      
• control  • ENU      comparison  
20 strains   age 3-16mo
  Inbred


  
Reference
Fenske TS, McMahon C, Edwin D, Jarvis JC, Cheverud JM, Minn M, Mathews V, Bogue MA, Province MA, McLeod HL, Graubert TA. Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice. Cancer Res. 2006 May 15;66(10):5029-38.     PubMed 16707424     MGI

Related papers       Cite the MPD data set

MiceStrain and animal info
Changelog 2 updates or corrections were posted since MPD release in Jul 2008  
Note
Some measurements are not eligible for all-MPD pheno vs. pheno
correlations due to data characteristics or semantics [View list]

Graubert1
downloads


Individual animal data
Table format (.csv)
Individual animal data in table format, with one row per animal and one column per measurement.
Individual animal data
List format (.csv)
Individual animal data organized as one row per animal / measurement reading.
Strain means (.csv) Strain means with SD, N, other summary statistics. One row per strain / sex / measurement.
No supplemental data for this project. 

 See also MPD's general data download page for other options.





 




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