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Data set: Graubert1   (2006)

  Drug study: ENU-induced tumorigenesis in 20 inbred strains of mice
  An investigation of secondary malignancies and whether certain susceptibilities are genetically predetermined. Animals were evaluated for baseline hematology. Some animals were treated with N-nitroso-N-ethylurea (ENU) and then evaluated for tumor burden in the blood, lungs, and gastrointestinal system. There were two cohorts: 1) controls; 2) treated with 100 mg/kg body weight ENU i.p.
 

Study design: control vs. an intervention; 2 cohorts.
20 strains tested     female male     Test age: 9wks; 3-16mo
Sample sizes are 8.3 on average. ... Caution, some N ≤ 2 are present  [details]

  Investigators: Graubert TA, Watters JW, McLeod HL     [More info... papers, citing, funding]

  • Protocol / methods           • Ontology classifications           • Downloads

Graubert1
phenotype
measurements



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blood — hematology — cell counts         CBC  
Graubert1
white blood cell count (WBC; per volume x 103)   [n/µL] 20 strains   age 9wks
  Inbred
Graubert1
lymphocyte count (LYMP; units per volume x 103)   [n/µL] 20 strains   age 9wks
  Inbred
Graubert1
lymphocyte differential (percent of total WBC)   [%] 20 strains   age 9wks
  Inbred
Graubert1
neutrophil count (NEUT; units per volume x 103)   [n/µL] 20 strains   age 9wks
  Inbred
Graubert1
neutrophil differential (percent of total WBC)   [%] 20 strains   age 9wks
  Inbred
 
blood — hematology — hemoglobin         CBC  
Graubert1
hemoglobin (HGB)   [g/dL] 20 strains   age 9wks
  Inbred
 
blood — hematology — platelets         CBC  
Graubert1
platelet count (PLT; units per volume x 103)   [n/µL] 20 strains   age 9wks
  Inbred
 
cancer — tumor growth — gastrointestinal tumors         histopathology  
Graubert1
gastrointestinal (GI) tumor frequency rate [score]     control and  ENU 100mg/kg      
• control  • ENU      comparison  
20 strains   aging study
  Inbred
 
cancer — tumor growth — hematopoetic tumors         histopathology  
Graubert1
lymphoid tumor frequency rate [score]     control and  ENU 100mg/kg      
• control  • ENU      comparison  
20 strains   aging study
  Inbred
Graubert1
myeloid tumor frequency rate [score]     control and  ENU 100mg/kg      
• control  • ENU      comparison  
20 strains   aging study
  Inbred
 
cancer — tumor growth — lung tumors         histopathology  
Graubert1
lung adenoma frequency rate [score]     control and  ENU 100mg/kg      
• control  • ENU      comparison  
20 strains   aging study
  Inbred
Graubert1
lung carcinoma frequency rate [score]     control and  ENU 100mg/kg      
• control  • ENU      comparison  
20 strains   aging study
  Inbred




2 updates or corrections were posted since initial release in Jul 2008
 
Fenske TS, McMahon C, Edwin D, Jarvis JC, Cheverud JM, Minn M, Mathews V, Bogue MA, Province MA, McLeod HL, Graubert TA. Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice. Cancer Res. 2006 May 15;66(10):5029-38.     PubMed 16707424     MGI

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