|Project data set: Graubert1 (2006)|
Drug study: ENU-induced tumorigenesis in 20 inbred strains of mice
An investigation of secondary malignancies and whether certain susceptibilities are genetically predetermined.
Animals were evaluated for baseline hematology. Some animals were treated with
and then evaluated for tumor burden in the blood, lungs, and gastrointestinal system.
There were two cohorts: 1) controls;
2) treated with 100 mg/kg body weight ENU i.p.
control vs. intervention;
20 strains tested
Graubert TA, Watters JW, McLeod H
View phenotyping protocol and methods
Number of mice tested per strain, for each measurement
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There have been
2 updates or corrections
to the data set since MPD release
Fenske TS, McMahon C, Edwin D, Jarvis JC, Cheverud JM, Minn M, Mathews V, Bogue MA, Province MA, McLeod HL, Graubert TA. Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice.
Cancer Res. 2006 May 15;66(10):5029-38.
Strain and animal info
Caution: Very low sample sizes (N < 3) are present.
Some measurements are not eligible for all-MPD pheno vs. pheno
correlations due to data characteristics or semantics
See also the MPD download center for more general data download options.