Ontology terms mapped to Gould4 measures:

  MP:0009711   abnormal conditioned place preference behavior MGI
  MP:0020160   abnormal behavioral response to nicotine MGI
  VT:0010721   response to nicotine trait
  VT:0010723   conditioned place preference behavior trait

Investigators	Munir G Kutlu       Temple University,  Philadelphia, PA Leonardo A Ortega       Temple University,  Philadelphia, PA Thomas J Gould       Temple University,  Philadelphia, PA
Contact	Thomas J Gould     tgould@temple.edu
Acknowledgements	Funding provided by NIH DA017949
Project type	Phenotype strain survey data set
MPD identifiers	Gould4     MPD:547
Data changelog	No updates/corrections.       Initial release date: 05/2016.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

The investigators used a conditioned place preference (CPP) paradigm to conduct an initial examination of the role of genetic background in the rewarding effects of nicotine. In the nicotine CPP procedure, some strains develop a preference for a chamber that is consistently paired with nicotine, which suggests that an association is made between the rewarding properties of nicotine and contextual stimuli. CPP training occurred in two phases with the first phase starting the day after the preconditioning session and consisted of three conditioning sessions (days 2-4). The first testing day was on day 5. The second phase of CPP training started on day 6 where mice underwent conditioning sessions on days 6-9. The second testing day was on day 10.

Procedures conducted:

• conditioned place preference test

Nicotine preference and learning effect. Nicotine-treated vs. control. 2 trials (day 5, day 10).