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Project data set: Frankel1   (2000)

Project Drug study: Induced seizures and their suppression with lamotrigine in 16 inbred strains of mice

An electroconvulsive threshold test was applied to assess frontal and transcorneal induced seizures and their suppression with lamotrigene.

Study design: baseline and intervention; 3 cohorts.
16 strains tested     female male     Test age: 6-11wks

Investigators Frankel WN, White HS   [Details, papers]

Protocol View phenotyping protocol and methods

Frankel1
measurements



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brain — electroconvulsive threshold         pulse generator  
Frankel1
critical current required for 50% of mice (CC50) to reach minimal clonic seizure [mA]        
electrode placement: • frontal (BH)   • transcorneal (BH)   • transcorneal (SL)     • comparison   		16 strains   age 6-11wks
  Inbred
Frankel1
critical current required for 50% of mice (CC50) to reach maximal tonic hindlimb seizure [mA]        
electrode placement: • frontal (BH)   • transcorneal (BH)   • transcorneal (SL)    • comparison   		16 strains   age 6-11wks
  Inbred
Frankel1
critical current required for 50% of mice (CC50) to reach psychomotor seizure [mA]        
electrode placement: • frontal (BH)   • transcorneal (BH)   • transcorneal (SL)    • comparison   		14 strains   age 6-11wks
  Inbred
Frankel1
median effective lamotrigine dose against minimal clonic seizures (at CC97) [mg/kg]   lamotrigine      
electrode placement: • transcorneal (BH)  • transcorneal (SL)    • comparison   		3 strains   age 6-11wks
  Inbred
Frankel1
median effective lamotrigine dose against maximal tonic hindlimb
extension seizure (at CC97) [mg/kg]   lamotrigine      
electrode placement: • transcorneal (BH)  • transcorneal (SL)    • comparison   		3 strains   age 6-11wks
  Inbred



Number of mice tested per strain, for each measurement

  
Changelog There has been one update or correction to the data set since MPD release in May 2001  
Reference
Frankel WN, Taylor L, Beyer B, Tempel BL, White HS. Electroconvulsive thresholds of inbred mouse strains. Genomics. 2001 Jun 15;74(3):306-12.     PubMed 11414758     MGI

Related papers
Mice
Strain and animal info
Note
For each strain/sex/measurement the following summary data were supplied: median value, N, and the 95% confidence interval. (In this project these median values are referred to as "means" in MPD data displays but they are really medians as described). Measurements for individual mice were not supplied. Assays were performed at two sites, Bar Harbor and Salt Lake City.

Measurement descriptions use the following abbreviations:
CC50 = Critical current (milli Amps) for 50% of the mice of a strain to reach seizure response (endpoint)

CC97 = Critical current (milli Amps) for 97% of the mice of a strain to reach seizure response (endpoint)

ED50 = Median effective dose (mg/kg)

BH = Assays performed in Bar Harbor

SL = Assays performed in Salt Lake City


Frankel1
downloads


Individual animal dataNot accessioned
Strain means (.csv) Strain means with SD, N, other summary statistics. One row per strain / sex / measurement.
No supplemental data for this project. 

 See also the MPD download center for more general data download options.




 




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