Crowley1: Drug study: Haloperidol-induced vacuous chewing movements, extrapyramidal side effects, and spontaneous locomotor activity in males of 27 inbred mouse strains (2012)

Crowley JJ, Adkins DE, Pratt AL, Quackenbush CR, van den Oord EJ, Moy SS, Wilhelmsen KC, Cooper TB, Bogue MA, McLeod HL, Sullivan PF. Antipsychotic-induced vacuous chewing movements and extrapyramidal side effects are highly heritable in mice. Pharmacogenomics J. 2012 Apr;12(2):147-55. doi: 10.1038/tpj.2010.82. Epub 2010 Nov 16.   PubMed 21079646     FullText


         
Crowley1 downloads
• Download Crowley1 project data set     animal data, as uploaded
• Download Crowley1 animal data matrix     with factor-related expansion applied as necessary
• Download Crowley1 strain means, SD, N, etc.     one row per strain/sex/measure
• Crowley1 supplementary data
Investigators James J Crowley       University of North Carolina,  Chapel Hill, NC
Howard L McLeod       University of North Carolina,  Chapel Hill, NC
Patrick F Sullivan       University of North Carolina,  Chapel Hill, NC
Participants Adkins DE, Pratt AL, Quackenbush CR, van den Oord EJ, Moy SS, Wilhelmsen KC, Cooper TB
ContactJames J Crowley     crowley@unc.edu     Lab web site
AcknowledgementsFunding provided by NIH GM63340, MH90338, HD03110, MH080403, MH077139, MH074027.

Mice provided through a collaboration with the Mouse Phenome Project, The Jackson Laboratory.
Project type Phenotype strain survey data set
MPD identifiersCrowley1     MPD:394
Data changelog No updates/corrections.       Initial release date: 11/2011.
Formatted citation
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Mice were implanted with 60-day release haloperidol pellets to produce a steady-state plasma concentration at levels therapeutic for humans (chronic exposure). Mice were subjected to a battery of behavioral tests at specified times post-implant, including times post-exposure (>day 60) to study the long-term effects of haloperidol. There was one cohort; baseline measurements were done prior to implantation, and plasma haloperidol levels were determined at specified times post-implant.

Procedures conducted:
• body weight  Baseline vs. after haloperidol 60d implant.
• drug and metabolite quantification  Haloperidol concentration (plasma). Baseline vs. during and after haloperidol 60d implant (several timepoints).
• inclined screen test  Baseline vs. during and after haloperidol 60d implant (several timepoints).
• open field test  Locomotor activity, exploratory behavior, involuntary movement. Baseline vs. haloperidol 60d implant (several timepoints). 60 min test.
• behavior observation  Observed involuntary repetitive movement. Baseline vs. during and after haloperidol 60d implant (several timepoints).

Mice: inbred w/CC8   27 strains   ♂   age 9-28wks   1 experimental group