|Project data set: Crowley1 (2010)|
Drug study: Haloperidol-induced vacuous chewing movements, extrapyramidal side effects, and spontaneous locomotor activity in males of 27 inbred mouse strains
Mice were implanted with 60-day release
pellets to produce a steady-state plasma concentration at levels therapeutic for humans (chronic exposure).
Mice were subjected to a battery of behavioral tests at specified times post-implant, including times
post-exposure (>day 60) to study the long-term effects of haloperidol. There was one cohort;
baseline measurements were done prior to implantation, and plasma haloperidol
levels were determined at specified times post-implant.
Study design: baseline vs. an intervention;
Sample sizes are 5.7 on average.
Crowley JJ, McLeod HL, Sullivan PF [Project details, papers, citing]
View phenotyping protocol and methods
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Crowley JJ, Adkins DE, Pratt AL, Quackenbush CR, van den Oord EJ, Moy SS, Wilhelmsen KC, Cooper TB, Bogue MA, McLeod HL, Sullivan PF. Antipsychotic-induced vacuous chewing movements and extrapyramidal side effects are highly heritable in mice.
Pharmacogenomics J. 2012 Apr;12(2):147-55. doi: 10.1038/tpj.2010.82. Epub 2010 Nov 16.
See also a related paper
|Strain and animal info|
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