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Project data set: Crowley1   (2010)

Project Drug study: Haloperidol-induced vacuous chewing movements, extrapyramidal side effects, and spontaneous locomotor activity in males of 27 inbred mouse strains

Mice were implanted with 60-day release haloperidol pellets to produce a steady-state plasma concentration at levels therapeutic for humans (chronic exposure). Mice were subjected to a battery of behavioral tests at specified times post-implant, including times post-exposure (>day 60) to study the long-term effects of haloperidol. There was one cohort; baseline measurements were done prior to implantation, and plasma haloperidol levels were determined at specified times post-implant.

Study design: baseline vs. an intervention; 1 cohort.
27 strains tested     male only     Test age: 9-28wks
Sample sizes are 5.7 on average.  [details]

Investigators Crowley JJ, McLeod HL, Sullivan PF     [Project details, papers, citing]

Protocol View phenotyping protocol and methods

Crowley1
measurements



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behavior — balance and coordination         inclined screen test  
Crowley1
extrapyramidal side effects (EPS) [s]     baseline and  haloperidol      
day: • 0  • 3  • 7  • 30  • 60  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
 
behavior — exploratory         open field test  
Crowley1
center occupancy [%]     baseline and  haloperidol      
day: • 0  • 30  • 60  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
 
behavior — involuntary movement         observation  
Crowley1
tongue protrusion [n]     baseline and  haloperidol      
day: • 0  • 30  • 60  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
Crowley1
overt chewing movement [n]     baseline and  haloperidol      
day: • 0  • 30  • 60  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
Crowley1
subtle chewing movement [n]     baseline and  haloperidol      
day: • 0  • 30  • 60  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
Crowley1
jaw tremor [s]     baseline and  haloperidol      
day: • 0  • 30  • 60  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
 
behavior — involuntary movement         open field test  
Crowley1
repetitive behavior (stereotypy) [n]     baseline and  haloperidol      
day: • 0  • 30  • 60  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
 
behavior — locomotor activity         open field test  
Crowley1
distance traveled [cm]     baseline and  haloperidol      
day: • 0  • 30  • 60  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
Crowley1
vertical activity [n]     baseline and  haloperidol      
day: • 0  • 30  • 60  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
 
blood — xenobiotics — drug and metabolite concentration         mass spectrometry  
Crowley1
plasma haloperidol concentration [nM]   haloperidol      
day: • 30  • 60  • 90  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
 
body weight         scales  
Crowley1
body weight [g]     baseline and  haloperidol      
• starting  • ending      time comparison  
27 strains   age 9-28wks
  Inbred


  
Reference
Crowley JJ, Adkins DE, Pratt AL, Quackenbush CR, van den Oord EJ, Moy SS, Wilhelmsen KC, Cooper TB, Bogue MA, McLeod HL, Sullivan PF. Antipsychotic-induced vacuous chewing movements and extrapyramidal side effects are highly heritable in mice. Pharmacogenomics J. 2012 Apr;12(2):147-55. doi: 10.1038/tpj.2010.82. Epub 2010 Nov 16.     PubMed 21079646     MGI     FullText

See also a related paper


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Changelog

No updates or corrections have been posted since MPD release in Nov 2011  

Crowley1
downloads


Individual animal data
Table format (.csv)
All individual animal data, table format, one row per animal and one column per measurement.
Individual animal data
List format (.csv)
All numeric animal data values, one row per animal per measurement.
Strain means (.csv) Strain means with SD, N, other summary statistics. One row per strain / sex / measurement.
Supplemental data are available

 See also MPD's general data download page for other options.





 




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