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Data set: Crowley1   (2010)

  Drug study: Haloperidol-induced vacuous chewing movements, extrapyramidal side effects, and spontaneous locomotor activity in males of 27 inbred mouse strains
  Mice were implanted with 60-day release haloperidol pellets to produce a steady-state plasma concentration at levels therapeutic for humans (chronic exposure). Mice were subjected to a battery of behavioral tests at specified times post-implant, including times post-exposure (>day 60) to study the long-term effects of haloperidol. There was one cohort; baseline measurements were done prior to implantation, and plasma haloperidol levels were determined at specified times post-implant.
 

Study design: baseline vs. an intervention   1 cohort.
27 strains tested     male only     Test age: 9-28wks
Sample sizes are 5.7 on average.  [details]

  Investigators: Crowley JJ, McLeod HL, Sullivan PF     [More info... papers, citing, funding]

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Crowley1
phenotype
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behavior — balance and coordination         inclined screen test  
Crowley1
extrapyramidal side effects (EPS) [s]     baseline and  haloperidol      
day: • 0  • 3  • 7  • 30  • 60  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
 
behavior — exploratory         open field test  
Crowley1
center occupancy [%]     baseline and  haloperidol      
day: • 0  • 30  • 60  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
 
behavior — involuntary movement         behavior observation  
Crowley1
tongue protrusion [n]     baseline and  haloperidol      
day: • 0  • 30  • 60  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
Crowley1
overt chewing movement [n]     baseline and  haloperidol      
day: • 0  • 30  • 60  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
Crowley1
subtle chewing movement [n]     baseline and  haloperidol      
day: • 0  • 30  • 60  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
Crowley1
jaw tremor [s]     baseline and  haloperidol      
day: • 0  • 30  • 60  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
 
behavior — involuntary movement         open field test  
Crowley1
repetitive behavior (stereotypy) [n]     baseline and  haloperidol      
day: • 0  • 30  • 60  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
 
behavior — locomotor activity         open field test  
Crowley1
distance traveled [cm]     baseline and  haloperidol      
day: • 0  • 30  • 60  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
Crowley1
vertical activity [n]     baseline and  haloperidol      
day: • 0  • 30  • 60  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
 
blood — xenobiotics — drug and metabolite concentration         mass spectrometry  
Crowley1
plasma haloperidol concentration [nM]   haloperidol      
day: • 30  • 60  • 90  • 120      time comparison  
27 strains   age 9-28wks
  Inbred
 
body weight         body weight  
Crowley1
body weight [g]     baseline and  haloperidol      
• starting  • ending      time comparison  
27 strains   age 9-28wks
  Inbred




No updates or corrections have been posted since initial release in Nov 2011
 
Crowley JJ, Adkins DE, Pratt AL, Quackenbush CR, van den Oord EJ, Moy SS, Wilhelmsen KC, Cooper TB, Bogue MA, McLeod HL, Sullivan PF. Antipsychotic-induced vacuous chewing movements and extrapyramidal side effects are highly heritable in mice. Pharmacogenomics J. 2012 Apr;12(2):147-55. doi: 10.1038/tpj.2010.82. Epub 2010 Nov 16.     PubMed 21079646     MGI     FullText

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