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Project data set: Crabbe3   (2003)

Project Drug study: Evaluation of ethanol intoxication using the rotorod in 22 inbred strains of mice

Animals were evaluated on an accelerating and fixed speed rotarod following ethanol administration. This project has a complex study design involving multiple cohorts, as described in the protocol workflow table.

Study design: baseline and intervention in various doses; 9 cohorts.
22 strains tested     female male     Test age: 9-17wks

Investigators Crabbe JC, Wahlsten D   [Details, papers]

Protocol View phenotyping protocol and methods

Crabbe3
measurements



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          Ontologies


behavior — balance and coordination         rotarod  
Crabbe3
fixed speed 3 rpm rotarod (latency to fall) [s]   ethanol
      ethanol i.p. g/kg: • 1  • 2  • 3    • comparison  
9 strains   age 9-17wks
  Inbred
Crabbe3
fixed speed 6 rpm rotarod (latency to fall) [s]   ethanol
      ethanol i.p. g/kg: • 1  • 2  • 3    • comparison  
9 strains   age 9-17wks
  Inbred
Crabbe3
fixed speed 10 rpm rotarod (latency to fall) [s]   ethanol
      ethanol i.p. g/kg: • 1  • 2  • 3    • comparison  
9 strains   age 9-17wks
  Inbred
Crabbe3
accelerating rotarod (latency to fall) - acquisition trials 20 rpm/min [s]  
      • performance  • improvement 
8 strains   age 9-17wks
  Inbred
Crabbe3
accelerating rotarod (latency to fall) - test day 1 20 rpm/min (ARR1) [s]     baseline and  ethanol various i.p.
      • baseline  • ethanol  • Δchange (ethanol effect) 
8 strains   age 9-17wks
  Inbred
Crabbe3
accelerating rotarod (latency to fall) - test day 2 30 rpm/min (ARR1) [s]     baseline and  ethanol various i.p.
      • baseline  • ethanol  • Δchange (ethanol effect) 
8 strains   age 9-17wks
  Inbred
Crabbe3
accelerating rotarod (latency to fall) - acquisition trials 20 rpm/min (ARR2) [s]  
      • performance  • improvement 
21 strains   age 9-17wks
  Inbred
Crabbe3
accelerating rotarod (latency to fall) - test 20 rpm/min (ARR2) [s]     baseline and  ethanol 2g/kg i.p.
      • baseline   • ethanol   • Δchange (ethanol effect)   • Δchange (saline control) 
21 strains   age 9-17wks
  Inbred


local experiment parameter  
Crabbe3
body weight on test day   [g]
9 strains   age 9-17wks
  Inbred



Number of mice tested per strain, for each measurement

  
Changelog There have been no updates or corrections to the data set since MPD release in Feb 2010  
Reference
Rustay NR, Wahlsten D, Crabbe JC. Assessment of genetic susceptibility to ethanol intoxication in mice. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2917-22. Epub 2003 Feb 12.     PubMed 12584362     MGI

Mice
Strain and animal info
Note
Caution: Very low sample sizes (N < 3) are present. [View table]
Note
Some measurements are a mixture of + and – values. [View list]

Crabbe3
downloads


Individual animal data
Table format (.csv)
Individual animal data in table format, with one row per animal and one column per measurement.
Individual animal data
List format (.csv)
Individual animal data organized as one row per animal / measurement reading.
Strain means (.csv) Strain means with SD, N, other summary statistics. One row per strain / sex / measurement.
Supplemental data are available

 See also the MPD download center for more general data download options.





 




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