Bouma1: Gonadal and sex research in a backcross of Dax1 XY mice (2005)
Bouma GJ, Albrecht KH, Washburn LL, Recknagel AK, Churchill GA, Eicher EM. Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells.
Development. 2005 Jul;132(13):3045-54.
Bouma1 downloads
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Use the QTL Data Downloads button near the bottom of this page.
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Ontology terms mapped to Bouma1 measures:
| Investigators |
G J Bouma Gary A Churchill The Jackson Laboratory, Bar Harbor, ME |
| Participants | Albrecht KH, Washburn LL, Recknagel AK, Eicher EM |
| Contact | Gary A Churchill gary.churchill@jax.org |
| Affiliated Center | QTL Archive |
| Acknowledgements | This study was supported by NIH grants GM20919 (E.M.E.), HD07065-25 (G.J.B.), GM070683(G.A.C.) and HD042779 (K.H.A.), and NCI core grant CA34196 (The Jackson Laboratory). |
| QTL Archive data set | |
| MPD identifiers | Bouma1 MPD:159 |
| No updates/corrections. Initial release date: 04/2010. |
The nuclear receptor transcription factor Dax1 is hypothesized to play a role in testicular development. A backcross with mutant Dax1 was generated to identify the function of the gene. 128 male mice were measured for fetal gonads and given different scores based on that. The scores were used to do QTL analysis to test the hypothesis. For detailed protocols see Bouma et al, 2005.
| Progenitor strains | B6-Dax1-/+ B6-Dax1+/Y DBA/2J |
| Cross direction notation | (B6 Dax1-/+ x D2) F1 x B6-Dax1+/Y |
| Cross type | Backcross |
| Population size | 0 ♀ 148 ♂ |
| Notes | 148 Dax1-/Y mice |
Project / data set: Bouma1 a.k.a. Bouma_2005
Excel file: Data_Description_BxDbackcross_Bouma2005.xlsx
CSV file: Bouma2005_BxD_B37_Data.csv
Readme / text file: ._readme.txt
Readme / text file: readme_Bouma2005.txt
QC plots, figures, etc.: QCReport_Bouma2005.pdf